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Biomedical subjects

H Lewi

Publications and source records attributed to H Lewi.

13 recordsLinked to original sources
PubMed1989

Therapeutic management of upper urinary tract stone disease in 172 subjects.

Three hundred one patients with recurrent renal calculi were studied: 129 patients received no treatment, and 172 received either bendrofluazide (90) or allopurinol (82). The renal stone recurrence rate was assessed over a five-year period, and it was noted that the incidence of recurrence was significantly lower in patients receiving either bendrofluazide or allopurinol. In male patients there was no difference in recurrence rates in those receiving the different drugs, but female patients receiving allopurinol had a significantly lower five-year recurrence rate when compared with those receiving bendrofluazide.

Administration, Oral↗
PubMed1988

Cytotoxic-loaded albumin microspheres: a novel approach to regional chemotherapy.

Adriamycin-loaded albumin microspheres (15-40 micron diameter) incorporating 1 per cent by weight of Adriamycin were prepared by cross linking albumin with glutaraldehyde. After systemic administration in rats, the microspheres were trapped in the pulmonary capillary bed, biodegradation occurring over 48 h. After selective intrarenal arterial injection of 99mTc-labelled albumin microspheres in rabbits, 97 per cent of the injected microspheres were trapped within the kidney; less than 1 per cent were found in the contralateral kidney, lungs and liver. Similar results were obtained after selective intrahepatic arterial injection. The selective injection of cytotoxic-loaded microspheres may provide a reliable method of administering high concentrations of cytotoxic drug to a target organ without producing high serum levels; this technique may have a role in the management of solid tumours.

Animals↗
PubMed1984

Pre-operative carcino-embryonic antigen and survival in patients with colorectal cancer.

The relationship between pre-operative levels of carcino-embryonic antigen (CEA), resectability of the primary tumour, the extent of tumour spread and subsequent survival was studied in 333 patients with colorectal cancer. Twenty-five per cent of patients undergoing 'curative' resection had elevated CEA levels compared with fifty-six per cent of patients receiving palliative treatment. Twenty-five per cent of patients with Dukes B or C tumours had elevated pre-operative CEA levels compared with seventy per cent of patients with stage D disease. In patients undergoing 'curative' resection there was no correlation between pre-operative CEA levels and subsequent survival. In patients undergoing palliative resection, elevated pre-operative CEA levels were associated with poor survival. Although pre-operative levels of CEA reflect the extent of the underlying disease process, estimations of pre-operative CEA levels are of limited value in predicting patients with a poor prognosis following curative resection for colorectal carcinoma.

Carcinoembryonic Antigen↗
PubMed1984

Netilmicin sulfate prophylaxis in the surgical treatment of renal stones.

The role of short course (three doses) and single dose peroperative antibiotic (netilmicin sulfate) prophylaxis were studied in 42 patients undergoing removal of renal calculi. In an untreated group, the urine sample taken preoperatively was infected in 37.5 per cent, but the removed stone demonstrated significant bacterial growth in 67 per cent, with a wound complication rate of 25 per cent. Use of antibiotic prophylaxis reduced the wound complication rate to 5 per cent. Satisfactory serum levels of the antibiotic were achieved during the operative period, with an acceptable rate of clearance of netilmicin sulfate from the blood stream.

Creatinine↗
PubMed1983

A prospective study of the development of hypertension and renal stone disease in subjects with increased blood urate.

The results of a prospective study of the development of hypertension and renal stone disease in subjects with increased blood urate are reported and compared with matched controls. None of the 14 patients on Allopurinol developed a renal stone but one untreated control did. For male patients there was a significant difference (p less than 0.01) in diastolic blood pressure between the 2 groups over the 5-year study period, with treated patients having higher blood pressures than untreated controls. This suggests that Allopurinol has had no effect on lowering diastolic blood pressure. Long-term therapy with Allopurinol was effective in reducing mean blood urate levels. It is suggested that blood urate levels are more relevant in predicting renal stone formation and of less value in assessing the therapy and prognosis in hypertension.

Allopurinol↗