[Current treatment of migraine].
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Biomedical subjects
Publications and source records attributed to H Liaño.
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Two patients, one of them with myasthenia gravis, presented symptoms of continuous muscle fiber activity syndrome before discovery of a thymoma. Peripheral neuropathy was present in both patients, with axonal and demyelinating lesions in sural nerve biopsy. The syndrome remained unchanged or worse after thymectomy. Both patients died of associated complications.
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A 37-year-old woman with hepatic failure developed a locked-in syndrome after correction of a severe symptomatic hyponatremia. Magnetic resonance imaging showed a lesion involving the basis pontis and extending into the midbrain, consistent with central pontine myelinolysis. In this patient the rate of correction of hyponatremia was within the range considered sure by several authors, but factors such as hepatic encephalopathy, a single generalized seizure and correction of hyponatremia in 42 h with a change in serum sodium concentration of 34 mmol/l were present, and they could have been etiologically relevant. This case, like other recent reports, suggests new views about the pathogenesis of cerebral demyelinating lesions in patients with hyponatremia.
Myocarditis and neurological disorders are the most serious complication of human infestation by Trichinella spiralis. On occasion, the unawareness of clinical manifestations, the form of presentation and the association of uncustomary neurological symptoms impedes the diagnosis of trichinosis. We report a case of trichinosis with peripheral facial diplegia, meningeal disorder and EKG alteration, with no prior intestinal symptomology. Treatment with thiabendazole and steroids resulted in a very favorable clinical evolution.
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A study was carried out on 100 cases with the clinical diagnosis of multiple sclerosis. Several clinical and analytical factors were considered and correlated. Special attention was paid to data obtained from cerebrospinal fluid (CSF) electrophoresis. The degree of severity of the disease does not affect the selective evaluation frequency of gamma-globulin or its average values. A greater frequency of definite gamma-globulin increase is observed in patients with a stationary development than in those a progressive development although, in both instances, the average values of gamma-globulin do not show any significant difference. There is no correlation between the CSF data and the presumed clinical site of the lesion. Those patients with a single lesion have a lower incidence of pathological data in CSF than those with multiple lesions. A higher proportion of pathological results is seen in CSF of patients with a chronic evolution from the onset than in chronic-intermittent cases. The cases studied during a relapse show a marked decrease in the frequency of definite gamma-globulin increase and paretic colloidal curves. This group of patients gives lower average values of gamma-globulin, total protein and cells, than those patients examined out of relapse. These results are in agreement with recent immunopathological observations.
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