[Lymphoid tumor of the cavum in HIV infection].
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Biomedical subjects
Publications and source records attributed to H Lida.
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Two patients presented with a large tumoral nasopharyngeal lesion with obstructive symptoms, which suggested a malignant tumor. They were black men of Caribbean origin who were infected with human immunodeficiency virus 1. In both cases, histologic examination revealed intense but benign lymphoid follicular hyperplasia, and immunohistochemical studies were consistent with its polyclonal nature. DNA studies performed on tumoral tissue failed to disclose immunoglobulin or T-cell receptor gene rearrangements. In one biopsy specimen, DNA hybridization using Epstein-Barr virus-specific probes showed no evidence of Epstein-Barr virus-DNA sequences. The nasopharynx can be involved in the diffuse extranodal lymphoid hyperplasia associated with human immunodeficiency virus infection.
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For choosing the size and location of the acetabular component, we have developed a three-dimensional simulation system based on computerized tomography and a microcomputer. In 34 cases of coxarthrosis secondary to congenital dysplasia or dislocation, the system provided valuable preoperative information.
HIV virus infection is frequently accompanied by polyclonal or monoclonal lymphoid proliferations. The authors report the first case of a tumour of the cavum in a Haitian subject with HIV infection. This large tumour was associated with parotid swelling and a buccal and ocular sicca syndrome. Histological examination revealed Sjögren type of lympho-epithelial infiltration in the parotid and salivary glands. Biopsy of the cavum demonstrated lymphoid hyperplasia without a monoclonal component. There was no lymphoid proliferation outside of the ear, nose and throat region. The various benign and malignant lymphoid proliferations observed during HIV infection are recalled. Their pathophysiology is discussed: role of EBV in B cell lymphoid proliferations, specific cytotoxicity against cells infected by HIV in T8 proliferations.
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