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Biomedical subjects

H Liebau

Publications and source records attributed to H Liebau.

At least 19 recordsLinked to original sources
PubMed1990

[Long-term antihypertensive therapy with urapidil. A 3-year open, multicenter trial of tolerance, safety and effectiveness].

Within the framework of an open, multicenter study of 16 physicians treated 206 hypertensive patients with a daily dose of 2 x 30 mg to 2 x 90 mg of urapidil over a period of 3 years. Data are available on 182 patients for the entire study period. 24 patients discontinued the study due to adverse effects (n = 2), an inadequate effect (n = 2), or for reasons unrelated to therapy (n = 20); 58 (28.2%) patients had complaints. The most frequently reported symptoms were nausea, dizziness, drowsiness and fatigue. No relevant changes in laboratory values were observed. Average body weight remained constant and there were no signs of sodium or water retention. In the first year systolic blood pressure was reduced by 25 mm Hg from 174 +/- 13 mm Hg to 149 +/- 10 mm Hg (mean value +/- SD), and diastolic pressure by 17 mm Hg from 103 +/- 6 mm Hg to 86 +/- 6 mm Hg. At the same average dose this drop in BP persisted in the second year (150 +/- 12/86 +/- 7 mm Hg) and the third year (146 +/- 10/85 +/- 7 mm Hg), indicating that there was no decrease in urapidil effect. The pulse rate fell from 77 +/- 8 beats/minute to 74 +/- 6 beats/minute and remained virtually constant over the next 2 years.

Adult↗
PubMed1983

[Effect of thiopental anesthesia on plasma renin, adrenaline and noradrenaline in neurosurgical operations with induced hypotension].

Excessive postoperative blood pressure reactions following surgery of cerebral aneurysms using sodium nitroprusside--induced hypotension can be avoided, if barbiturate-fentanyl-anaesthesia is employed instead of neuroleptanalgesia. Plasma renin activity (PRA), plasma concentration of adrenaline and noradrenaline were determined in 13 patients, undergoing surgery of cerebral aneurysms with induced hypotension (group I) and in 15 patients, who were operated on for brain tumors without hypotension (group II). The PRA was not increased in group II. The blood pressure was normal. In group I the PRA was significantly higher during and after the operation. In both groups adrenaline was not increased significantly. The noradrenaline concentration showed a significant increase in both groups, indicating a peripheral sympathetic stimulation. It is supposed that thiopentone inhibits the depletion of adrenaline and reduces the effect of increased PRA.

Adult↗
PubMed1977

Role of sodium and water in hypertensive patients on maintenance hemodialysis.

In 46 patients of the chronic hemodialysis program blood pressure regulation was studied according to variations of sodium and fluid balance. A strong relationship was observed between blood pressure and the amount of exchangeable sodium. In the hypertensive patients exchangeable sodium was increased depite fulfilled clinical signs of sufficient dehydration. The blood volume was found to be small and the plasma renin activity increased in those hypertensive patients, in which sufficient fluid depletion was inhibited by extreme fluctuations of the blood pressure during dialysis. A diminution of the sodium concentration keeping the fluid balance constant induced an increase of blood pressure and deteriorated the subjective feeling of the patients. By an increase of the sodium concentration up to 155 mEq/l severe blood pressure fluctuations during during dialysis could be prevented, although further fluid was taken off by ultrafiltration. This effect seemed to be mediated--at least partly--by an increase of the low blood volume and a suppression of plasma renin activity. After the patients became normotensive, dialysis procedure could be continued with normal sodium concentration. By a temporary high sodium regimen of the dialysis procedure some patients with renal failure and 'uncontrollable hypertension' can be preserved from bilateral nephrectomy.

Adult↗