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Biomedical subjects

H Liedloff

Publications and source records attributed to H Liedloff.

At least 19 recordsLinked to original sources
PubMed1989

[Drug prevention of thromboembolism in elective hip surgery with reference to thrombophilic conditions].

Within two prospective controlled clinical studies in the clinic and outpatient department for orthopaedics of the Erfurt Medical Academy in the period from 1980 to 1985 on 437 patients with alloarthroplasties of the hip examinations with various medicaments concerning the frequency of thromboembolic diseases were carried out. By means of haemostaseologic investigations could be confirmed that fibrinolytic defects could be removed in the majority of cases by the treatment with dehydrochlormethyl testosterone. This form of the treatment and the combination low-dose heparin and dihydroergotamine as medicamentous prophylaxis showed the best effect. The analyses of the haemostaseologic investigations only conditionedly allow a statement about the fact whether in the individual case there is a readiness for thrombosis.

Aged↗
PubMed1988

Evaluation of preoperative blood tests for predicting deep vein thrombosis after total hip replacement.

Determinations of the total calcium content and aggregability of the platelets as well as tests of coagulation and fibrinolysis were carried out on 93 patients before undergoing total hip replacement. All patients received low dose heparin, solely or combined with dihydroergotamine. Twenty-six patients developed deep vein thrombosis (DVT) detected by the labelled fibrinogen uptake test and confirmed by ascending phlebography. Only a few tests, among them the total calcium content of platelets, showed a statistical difference between the patients who subsequently developed DVT and those who did not. Combination of several tests by a multivariate statistical analysis programme proved to have more predictive value than the analysis of single tests.

Adult↗
PubMed1984

[Use of heparin in combination with dihydroergotamine for the postoperative prevention of thrombosis in hip joint surgery].

The risk of thromboembolism is particularly high in patients involved in hip replacement arthroplasty. Therefore, besides physico-mechanical measures, early mobilisation, compression bandages and physiotherapy they need an additional pharmacological prophylaxis of thromboembolism. In the present study the prophylactic efficacy of low-dose heparin in combination with dihydroergotamine was investigated in 200 patients undergoing hip replacement. While in comparison to the only administration of low-dose heparin the frequency of thromboses of the deep veins of the leg did not decrease significantly, the decrease of the frequency of pulmonary embolism under the combination obtained statistical significance. The results are compared with those of studies published in international literature. Consequently, the application of low-dose heparin in combination with dihydroergotamine represents a simple, highly effective prophylaxis against thromboembolism, but is not free from side-effects.

Clinical Trials as Topic↗
PubMed1984

[Measurement of the calcium content of thrombocytes as a contribution to the recognition of a disposition to thrombosis].

Calcium content of platelets from 57 patients undergoing total hip replacement was measured preoperatively. 13 patients developed deep vein thrombosis (D.V.T.) as recognized by 125I-fibrinogen technique and confirmed phlebographically. Preoperatively this group of patients exhibited a significant lower mean platelet calcium content than the group without postoperative D.V.T. It seems to be possible that special platelet parameters could hint an increased risk from postoperative D.V.T.

Adult↗
PubMed1979

[Early Awelysin therapy in massive pulmonary embolism after hip alloarthroplasty].

The fibrinolytic therapy of massive frest pneumatic embolism represents an ensured progress today. Until now it was only possible to report on those cases where the patients had survived at least two hours from the beginning of the acute event. Two cases are reported here where the patients were successfully treated in spite of a standstill in the circulation. In a 60 years old female patient and 54 years old female hypertonic patient a successful reanimation could be performed in the early postoperative phase by applying a high dosage of awelysin. The progress indicated that the therapy has led to a lysis or partial lysis of embolus respectively and thus again to a perfusion of the lungs. At the same time the serious bleeding complications clearly indicate the limits of this aggressive form of intensive therapy.

Arthroplasty↗