Genetics of somatic fusion in a myxomycete: F 2 studies.
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Biomedical subjects
Publications and source records attributed to H Ling.
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A 74-year-old man who had dyspnea and cyanosis demonstrated venous thrombosis and multiple lung ventilation-perfusion mismatches suggesting pulmonary emboli. Transthoracic echocardiography demonstrated a right atrial mass and a microbubble contrast study did not reveal right-to-left shunt. Transesophageal echocardiography revealed an embolus entrapped in the foramen ovale projecting into the left atrium that was subsequently removed. Embolic occlusion of patent foramen ovale is an important cause of false negative microbubble contrast study.
Increased renal ammoniagenesis is thought to be a causative factor for renal hypertrophy which occurs in several disorders accompanied by metabolic acidosis. We studied the influence of ammonia on the polarized release of degradation products of endogenous proteins in LLC-PK(1) cells. Release of acid-soluble radioactivity to the extracellular space decreased under the influence of NH(4)Cl with a remarkable transient reduction of basolateral release. Electron microscopically NH(4)Cl-treated cells showed numerous enlarged lysosomes suggesting an accumulation of incompletely degraded cytoplasmatic material in the lysosomal compartment. We conclude that split products of lysosomal degradation of endogenous proteins are preferentially transported to the extracellular space via the basolateral plasma membrane.
Two hundred thirty-six patient visits to a major university's ophthalmology clinic were studied to determine patient waiting time. The waiting time was studied as a function of attending physician and appointment time. Patient arrival behavior was also documented. Recommendations regarding strategies to reduce waiting times were developed based on the data. The recommendations include: redistributing patient appointments to less busy times of the day; educating patients regarding the importance of punctuality; and creating a realistic patient appointment schedule. Awareness of the importance of waiting time to the health care consumer is of particular significance for the health care provider. The study allows analysis of waiting times in order to target problem areas and provides a benchmark for evaluation of waiting time reduction efforts. These results could be applicable to most clinical settings with varying mixes of patients.
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