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Biomedical subjects

H Lorenz

Publications and source records attributed to H Lorenz.

7 recordsLinked to original sources
PubMed1979

Recognition of the pattern in ultrasonic sectional pictures of the prostate for tumor diagnosis.

To diagnose tumorous alterations of the prostate, we examined the organ with ultrasonics by scanning directly from the abdominal wall through the filled bladder (transvesical). The research is aimed at: 1) improvement and mathematical preparation of the ultrasonic pictures to assist the physician in his diagnosis. 2) ascertainment of significant parameters which allow the classes "normal prostate", "adenoma" and "carcinoma" to be distinguished in screening examinations. The results show that with ultrasonics, adenomas and carcinomas are recognizable in 96% of the examined patients and can be differentiated from normal prostate tissue. The palpation finding was used as a reference in most cases.

Humans↗
PubMed1976

[The quantitative cytoarchitecture of Morris hepatoma 66 (author's transl)].

INTRODUCTION AND METHODS: To obtain a statistic comparable picturg oncogenesis, tissue of a middle-fast growing Morris-hepatoma 66 was transplanted into the femoral musculature. 35 days later the animals were killed by decapitation and hepatoma tissue was taken. The morphometric analysis based on the technique described by Weibel (1969). RESULTS AND DISCUSSION: In the Morris-hepatoma 66 hepatocyte and nucleus show a much smaller single volume in comparison to normal liver cell. Smaller is also the number of nucleoli per nucleus. The decreased numerical density of mitochondria in liver tissue and their smaller content of mitochondrial grana suggest a reduction of the oxidative metabolism. The enlargement of membrane surface of the rough endoplasmatic reticulum in liver tissue is accompanied by a cisternal collapse. The smooth endoplastmatic reticulum is rudimentary in the hepatoma cells. The number of peroxisomes is equal in hepatoma and normal liver. Only half as large is, however, their volume density in liver tissue and so also their single volume.

Animals↗
PubMed1976

[Hamostasiological changes induced by platelet-aggregation-inhibitors, tested in children with congenital heart disease (in vitro and in vitro examinations) (author's transl)].

This report has delt with in vivo and in vitro examinations in the cases of sixteen children suffering from cyanotic congenital heart disease, and who had been placed under extended therapy with platelet-aggregation-inhibitors. The pharmacological effect of acetylsalicylic acid and dipyridamol has been discussed--as far as it is known. The discrepancy between in vivo and in vitro therapy-effect in the treatment with platelet-aggregation-inhibitors has been subjected to criticism. Consistant treatment of all children suffering from cyanotic congenital heart disease with aspirine and persantine has been advocated, however should only be carried out in collaboration with a competent hamostasiological laboratory.

Adolescent↗
PubMed1975

Linkage group HL-A-MLC-BF (properdin factor B). The site of the Bf locus at the immunogenetic linkage group on chromosome 6.

Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring. In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r = 6.1%). The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC. From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) -- HL-A (2nd locus)--MLC-Bf---PGM(3). The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.

Chromosome Mapping↗