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Biomedical subjects

H Ludes

Publications and source records attributed to H Ludes.

14 recordsLinked to original sources
PubMed1985

[Hormone and metabolism behavior in distress without physical stress].

The psychological effects on cortisol, human growth hormone (HGH), free fatty acids and lactate were investigated in 10 healthy students using a one hour television game. To insure that only the psychological aspects of the game were being measured, hematocrit, creatininkinase, CK-MB and myoglobin were used as controls. The game began 60 minutes after venapuncture of a lower arm vein with an indwelling catheter. Blood samples were taken 30 and 60 minutes after venapuncture, at intervals of 20 minutes during the game and 30, 60 and 120 minutes after the end of the game. After an initial rise, plasma cortisol levels sank steadily and significantly (alpha = 1%). The HGH level initially fell, but as the game progressed, rose and remained at a high level for a considerable period after the game had ended. These variations however were not statistically significant. The three free fatty acids under investigations, myristinic acid (C14), palmitic acid (C16), and stearic acid (C18), all showed similar levels over the course of the experiment. During the first 20 minutes of the play, free fatty acid levels rose, with stearic acid levels rising the most (52%). The free fatty acid levels then sank as the game progressed, with the palmitinic acid level showing a significant decline (alpha = 1%). The other parameters remained relatively constant during the experiment, with the exception of the CK-MB level, which showed severe, hard-to-interpret variations.

Adult↗
PubMed1976

[Frequency, diagnosis, and course of hepatotoxic side effects of Rifampicin (author's transl)].

In a retrospective study the following was found: Out of 111 patients suffering from tuberculosis and receiving a combined INH-therapy without Rifampicin 23% showed an increase of serum-transmainase activities, on the other hand out of 105 patients, treated with a combination including Rifampicin 74% did so. A pathological De Ritis ratio GOT/GPT was found in 31 among 59 comparable cases of Rifampicin-treated patients, and a pathological ratio GOT + GPT/AP in 22 among 37 cases before the transaminase-activities rose above normal. Development of a distinct toxic hepatic damage has to be anticipated in those cases, which show a De Ritis ratio below 0,5 or a GOT + GPT/AP ratio above 1,0 while transaminase-activity still is only slightly elevated. Liver biopsies taken from 10 patients showed no regular relation to the biochemical data.

Alanine Transaminase↗