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Biomedical subjects

H Lukjan

Publications and source records attributed to H Lukjan.

At least 19 recordsLinked to original sources
PubMed1987

Some haemorheological factors in patients with arteriosclerosis obliterans after treatment of trental.

Erythrocytes deformability, plasma cAMP, 6-keto-PGF1 alpha, TXB2 levels and fibrinolytic activity in patients suffering from arteriosclerosis obliterans before and after Trental were studied. Trental improved the deformability of red cells and resulted in an enhancement of diminished cAMP level in plasma and increased the fibrinolytic activity. The improvement of deformability observed after Trental could depend upon the influence of a higher cAMP level in plasma on the erythrocyte membrane. The increase of cAMP level seems to be the result of the inhibiting effect of Trental on phosphodiesterase and of higher fibrinolytic activity.

6-Ketoprostaglandin F1 alpha↗
PubMed1987

Certain biological function of leukocytes in venous thrombosis and influence of factors released during clot lysis.

In patients with venous thrombosis the behaviour of leukocyte random locomotion, migration, phagocytosis, blast transformation and NBT reduction properties were investigated. During the course of venous thrombosis the leukocyte adherence activity and their NBT reduction properties increased whereas their random locomotion decreased. The lymphocytes evaluated by the migration and blast transformation tests showed no signs of stimulation nor was their immunologic response changed. The thermolabile factor present in the clot lysis products affected only the adherence activity and the NBT reduction properties.

Adolescent↗
PubMed1986

Influence of fibrinolysis activation on leukocyte adhesiveness. Preliminary report.

In patients with thrombophlebitis receiving intravenously a nicotinic acid derivative, pentoxifylline and streptokinase the fibrinolytic activity and leukocyte adhesiveness were studied. The euglobulin lysis time was significantly shortened in all cases; at the same time the adhesiveness of leukocytes and the leukocyte number were reduced. The addition of the drugs to blood in vitro resulted in a significant increase in leukocyte adhesiveness; the fibrinolytic activity was enhanced only upon streptokinase. Leukocytes are believed to promote the thrombolytic effect of fibrinolytic agents.

Adult↗
PubMed1986

Clinical investigations on long-term activation of fibrinolysis by anabolic steroids.

The influence of anabolic steroids plus phenformin on the course of disease was studied in patients suffering from occlusive vascular diseases. In arteriosclerosis obliterans of the lower limbs the combined therapy led to a higher percentage of improvement than the control group showed. In coronary heart disease there was also a beneficial effect of this treatment. The drugs were found to exert beneficial clinical effects especially in patients with thrombophlebitis migrans and superficial thrombophlebitis. From the results of this study it is concluded that this therapy may be of clinical value in the treatment of patients with occlusive vascular diseases.

Adult↗
PubMed1985

The effect of HR (O-Beta-Hydroxyethylo-Rutoside, Venoruton) on the deformability of erythrocytes in patients with arteriosclerosis obliterans of lower limbs.

Deformability of red cells and plasma levels of cAMP and cGMP were studied in patients with arteriosclerosis obliterans of lower limbs. Deformability of red cells and plasma levels of cAMP were found to be decreased in these patients. Venous injection of HR (Venoruton) in one dose (1,000 mg) to patients, led to an increase of red cell deformability and normalisation of cAMP plasma level. The plasma level of cGMP was not changed. The beneficial effect of HR in arteriosclerosis obliterans depends, first of all, on improving the deformability of red cells. The decreased deformability observed in arteriosclerosis seems to be a result of disturbances in the rate of spectrin phosphorylation of the erythrocyte membrane. By normalising the plasma level of cAMP HR had a considerable influence on the appropriate state of elasticity of the red cell membrane.

Aged↗
PubMed1979

The effect of O-betahydroxyethyl-rutosides (HR) on the number of platelet-leukocyte aggregates in patients with occlusive arterial disease.

The diagnostic value and the effect of the therapy on the number and kind of platelet-leukocyte aggregates in 68 patients with arteriosclerosis obliterans of the lower limbs were investigated. The modified SILBERGLEIT'S method was used. 8 types of aggregates were found. The means number of aggregates in 20 healthy subjects was 8.2 but in 46 patients suffering from obliterative arteriosclerosis of the lower limbs this number was significantly higher, i.e. about 62. A significant decrease in the number of platelet-leukocyte aggregates in the group of 14 patients receiving HR orally 1800 mg daily and 16 patients receiving HR intravenously 2000 mg daily was found. In 16 persons a lower HR dose (orally 900 mg daily and intravenously 500 mg daily) did not influence the number of rosettes. In 22 patients receiving nicotinic acid (orally 900 mg daily, intramuscularly 600 mg daily) no significant changes in the number of rosettes was observed.

Administration, Oral↗
PubMed1979

Prophylaxis of recurrent venous thrombosis with long-term enhancement of fibrinolysis.

The effects of 6 months' combined therapy with phenformin and an anabolic steroid were compared in patients with thrombophlebitis migrans (12 patients) and those with superficial thrombophlebitis (15 patients). In both groups of patients an increase in blood fibrinolytic activity, and "capacity" decrease in platelet adhesiveness, plasma fibrinogen, blood lipids, beta lipoproteins as well as serum cholesterol level were found. A statistically significant decrease in frequency of inflammations in patients with thrombophlebitis migrans occurred. In these patients a return of the previously low "fibrinolytic capacity" to normal values was observed. It seems that prolonged activation of fibrinolysis by means of phenformin and an anabolic steriod may be of value in the prophylaxis of venous thrombosis especially thrombophlebitis migrans.

Adult↗
PubMed1976

[The 131I-fibrinogen turnover during activation of blood fibrinolysis].

The influence of stanozolol Stromba and phenformin Dibotin (Winthrop) and complamin (Wulfing) on transformation of 131J-fibrinogen administered intravenously was examined in 39 patients with arteriosclerosis obliterans. The patients were divided into 3 groups; one of the groups included untreated patients. Radioactivity of the plasma and of the urine was determined by means of a scintillation counter. The volume of plasma, plasma fibrinogen (g%, g, g/kg), half time of persistance (T 1/2) and degradation of fibrinogen were determined. The patients who received Dibotin and Stromba simultaneously showed statistically significant decrease of the plasma fibrinogen degradation im comparison to the control group. But in patients who received complamin in spite of significant decrease of the plasma fibrinogen (g%), the fibrinogen degradation was not different from the value obtained in the group.

Adult↗
PubMed1975

Experimental studies on activation of the kininogenic system after exclusion of the hepatic circulation.

Levels of kininogen and kallikrein activity were studied in the plasma of rabbits with ligated hepatic blood vessels. Ligation of hepatic veins and arteries arrested visceral circulation in the animals and produced symptoms of shock and death of the animals. Ligation of the superior mesenteric artery at the same time prevented these symptoms, creating an experimental model of exclusion of the liver. Fibrinolytic activation of the kininogenic system by intravenous injection of xanthinol nicotinate (Sadamin, Polfa) in rabbits with excluded hepatic blood circulation caused a rise in kallikrein activity and transient drop in levels of kininogen. Return to normal of kininogen levels in the animals with excluded liver indicated that the process of restoration of kininogen deficiency in the blood is a complex one, independent of direct kininogen synthesis in the liver or its release from the liver.

Animals↗