A healing promoting factor in rat wound fluid.
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Animals↗
Biomedical subjects
H Lundborg
Publications and source records attributed to H Lundborg.
Effects of portacaval anastomosis on liver and brain protein synthesis in rats.
In vivo and in vitro protein synthesis was measured in livers from rats 3 weeks after a portacaval shunt (PCS) operation. A marked reduction in protein synthesis was observed, amounting to a 66 and 47% of inhibition, respectively. Above-saturation levels of amino acids were used in both conditions. The level of free exogenous amino acid was elevated consistently in the PCS animals 1 hour after isotope injection. In support of the data on liver protein synthesis, the incorporated radioactivity in serum proteins was reduced markedly. Heart muscle protein synthesis was unchanged while brain protein synthesis was inhibited when assayed in vivo. Neuronal cells showed a more marked inhibition of protein synthesis than did glial cells.
Amino Acids↗
On the occurrence of lipoprotein-x in non-hemolytic jaundice.
In cholestasis, serum lipids are altered. The alterations could at least partially be ascribed to the occurrence of an abnormal lipoprotein, LP-X. In 103 patients with jaundice, out of whom 16 had extra-hepatic cholestasis, the presence of LP-X was tested and semi-quantificated (by visual grading) utilizing an immunological technique. In extra-hepatic cholestasis, all patients showed LP-X in serum, while in intra-hepatic drug-induced cholestasis 87% revealed this phenomenon. At the initial stage of acute hepatitis, in drug-induced cholestasis, and in extra-hepatic cholestasis, the semi-quantificated LP-X correlated with alkaline phosphatase values. In extra-hepatic cholestasis, LP-X disappeared soon after the obstruction was relieved by operation.
Bilirubin↗
Methanol-soluble glycoproteins in human liver and brain.
After disc electrophoresis on 15% polyacrylamid gels of water-soluble and theta 50% methanol-soluble proteins from human liver or brain we have found two protein bands which have not been described in the literature before. These two protein fractions have been eluated from a Concanavaline A-Sepharose column. In this paper we present data showing that one of the two protein fractions is found in greater amounts in human liver than in human brain.
Brain Chemistry↗