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Biomedical subjects

H Lunt

Publications and source records attributed to H Lunt.

At least 19 recordsLinked to original sources
PubMed2005

An alternative method of blood-feeding Culicoides imicola and other haematophagous Culicoides species for vector competence studies.

The use of cotton wool pads saturated with blood/virus mixture for oral infection attempts was compared to membrane feeding for the assessment of vector competence in C. imicola Kieffer and C. bolitinos Meiswinkel (Diptera, Ceratopogonidae). Although lower infection rates were obtained using pad feeding, it was possible to clearly distinguish the levels of competence between species as well as differences in virus infection rates for various serotypes of bluetongue virus. Reduced infection rates with cotton pad feeding was partly due to a smaller volume of blood meals taken up. However, the method described is likely to be useful in situations where membrane feeding is not viable to separate populations with significant differences in vector competence.

Animals↗
PubMed2004

Prospective audit of conversion from regular to lispro insulin during routine clinical care.

BACKGROUND: Randomized controlled trials show that lispro insulin has the potential to improve glycaemic control. Observational, practice-based studies provide information that is complementary to that obtained from randomized controlled trials and results of both types of studies are of relevance when advising patients of likely outcomes during routine clinical care. AIMS: This prospective audit aimed to determine whether conversion from regular (short-acting, soluble) preprandial insulin to lispro during routine clinical care improved glycated haemoglobin. METHODS: Eligible patients were those using regular insulin before main meals and a basal neutral protamine Hagedorn (NPH) insulin. Study group patients were those who chose to convert to lispro insulin. Patients who elected not to change their regimen were used as a comparison group. Follow up was for a minimum of 1 year. RESULTS: Glycated haemoglobin (HbA(1c)) and body mass index showed no change in either the study or comparison groups. Post-hoc analysis revealed that the patients most likely to improve their HbA(1c) on lispro were those with a higher baseline HbA(1c). Patients using lispro reported a decreased frequency of hypoglycaemia and improved convenience of use. CONCLUSIONS: Administration of lispro insulin was perceived by patients as convenient to use and was also associated with less hypoglycaemia when compared with the use of regular insulin. There was, however, no improvement in HbA(1c). This finding may be informative when advising patients during routine clinical care of the likely metabolic outcome of changing their insulin regimen.

Body Mass Index↗
PubMed2003

Testing the effectiveness of techniques for reducing heat strain in Royal Navy nuclear, biological and chemical cleansing stations' teams.

Nine personnel simulating the work of an NBC cleansing station (CS) in conditions expected in Middle Eastern waters had a limited work duration due to incapacitating heat strain. When the subjects were allowed five minutes rest periods after every 10 minutes of work, the endurance of seven of the subjects was limited to between 75-105 minutes due to heat strain and heat illness. By the point of withdrawal mean (SD) rectal temperature (Tre) had risen by 1.8 degrees C (0.4 degree C). The other two subjects were withdrawn earlier because they reached cardiac safety limits. When the hands were immersed (HI) in 10 degrees C water during the five minute rest periods heat strain was significantly lower (P < 0.01) and work endurance times were increased. One subject was withdrawn early on reaching cardiac safety limits, two on reaching Tre limits (39 degrees C) at 105 minutes, and six subjects completed the 180 minute exposure with a final Tre of 38.4 degrees C (0.3 degree C). Using 'iced' (0 degree C) rather than 10 degrees C water for HI further reduced heat strain (P < 0.01) and increased endurance times. Three subjects were withdrawn early on reaching cardiac safety limits, the remaining six completing the 180 minute exposure, with a final Tre of 38.3 degrees C (0.5 degree C). Using an ice-vest (IV) in conjunction with HI further reduced heat strain (P < 0.01) and increased endurance times. Two subjects were withdrawn early on reaching cardiac safety limits, the remaining seven completing the 180 minute exposure, with a final Tre of 38.2 degrees C (0.8 degree C) when 10 degrees C HI water was used, and Tre 38.0 degrees C (0.4 degree C) when 0 degree C HI water was used. There were no reports of finger numbness or loss of dexterity due to HI, and all personnel were able to remove their own individual Protective Equipment (IPE) without difficulty. It is expected that using HI will not reduce the ability to decontaminate or undress others. The HI technique and IV equipment should be introduced into the Fleet. 'Iced' water should be used in preference to 10 degrees C, although any water colder than 25 degrees C will provide some benefit. The IVs increased torso girth and personnel should try them on (with frozen ice packs inserted) prior to their use and ensure that their protective clothing still fits, or obtain a larger size.

Body Temperature↗
PubMed2000

Metabolic control and psychological sense of control in women with diabetes mellitus. Alternative considerations of the relationship.

PURPOSE: Identifying psychological strategies to buffer the adverse outcomes in people with diabetes mellitus (DM) remains a priority for many health professionals. While 'locus of control' (LOC) has been repeatedly investigated to this end, research findings are contradictory. The development of more complex appraisals of psychological control, and the utilization of control inventories deriving from such analyses, presents a way forward from such contradictions. METHODS: Employing such a measure, this study examines the relationship between metabolic control and psychological sense of control in 96 women with DM. RESULTS: Optimal metabolic control is significantly associated with overall sense of control, while poor metabolic control was significantly associated with experiences of loss of psychological control and feelings of inadequacy. Furthermore, poor metabolic control was significantly associated with reduced control in the specific domains of interpersonal relationships and bodily functions. CONCLUSIONS: Multidimensional control inventories enable a more complex appraisal of the relationship between metabolic control and psychological control, and in doing so, provide a way forward from problems arising from reliance on LOC constructs. Interventions for DM management relying on aspects of psychological control need to target domains beyond traditional issues of self and bodily functions.

Adult↗
PubMed2000

Diabetes in New Zealand.

While the ethnic make up of the New Zealand population is predominantly European, the Polynesian population, consisting of indigenous New Zealand Maori and more recent immigrants from the other Pacific Islands is increasing rapidly. The prevalence of diabetes in these Polynesians is high. There is also an increasing prevalence of obesity, and obesity is a greater problem amongst Polynesian people. The number of elderly people in the population is increasing. All of these demographic changes are increasing the incidence and prevalence of Type 2 diabetes. The incidence of Type 1 diabetes is also rising, although the reasons for this are unknown. Diabetic nephropathy is the most common cause of end stage renal failure in New Zealand. Polynesian people with diabetes, and in particular Maori, have a very high rate of diabetic nephropathy and develop renal failure at a more rapid rate than European patients with nephropathy relating to Type 1 diabetes. The propensity for Maori patients with Type 2 diabetes to develop renal failure may relate to a younger age at the onset of diabetes, a genetic susceptibility to nephropathy, and socio-economic or cultural factors leading to less adequate medical care.

Adolescent↗
PubMed1999

Diabetes complication screening in general practice: a two pass audit with benchmarking.

AIM: To determine whether a two pass audit cycle of diabetes complication screening improves screening rates. METHODS: General practitioners in North Canterbury were invited to participate in a diabetes complications screening audit. Key complication screening tasks and maximum screening intervals were agreed. Patients with diabetes were identified in the primary care setting. General practitioners were given the option of participating in group feedback sessions between the first and second passes of the audit cycle. RESULTS: 106 general practitioners and 2234 patients participated in the first pass. Ninety-three of these 106 general practitioners and 2169 patients participated in the second pass. Screening rates either improved or remained unchanged and a small improvement was seen in the study population's risk factor profile (i.e. total cholesterol and glycated haemoglobin). The group feedback sessions facilitated discussion on interpretation of results from the benchmarking exercise, the optimal time interval between screening procedures and the development of general practice diabetes data sets. CONCLUSION: This two pass primary care audit of diabetes complications screening resulted in improved screening rates for diabetes complications and a small improvement in the study population's risk factor profile.

Aged↗
PubMed1999

Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia.

In an ambulatory population of diabetic subjects (Type 1 and Type 2), the urine excretion of the renal osmolyte, glycine betaine, was compared to known markers of glycemic control, renal dysfunction and to the excretion of related betaines, including trigonelline, proline betaine, carnitine and acetyl-carnitine. Of the 85 subjects, 20 patients had urine glycine betaine concentrations above the reference range for normal subjects. Plasma glycine betaine concentrations were within reference ranges for normal subjects. Patients with elevated glycine betaine excretion tended to have lower plasma glycine betaine concentrations, but this did not reach statistical significance. One way analysis of variance found excretion is independent of treatment, duration of diagnosed diabetes, blood pressure and body mass index (BMI). An association between glycine betaine excretion and glycemic control was observed with statistically significant correlations occurring with both plasma glucose (r = 0.43, P < 0.001) and glycated haemoglobin (HbA1c) (r = 0.35, P < 0.005). The excretion of carnitine, acetyl-carnitine and proline betaine were related to glycine betaine excretion (r = 0.49, P < 0.001; r = 0.40, P < 0.001; r = 0.27, P < 0.05, respectively). Urine carnitine and acetyl-carnitine concentrations were also related to plasma glucose concentrations (r = 0.30, P < 0.01). Increased urine retinol binding protein concentrations (RBP), a marker of proximal tubular dysfunction, correlated with elevated urine glycine betaine excretion and plasma HbA1c (r = 0.28, P < 0.01). These results suggest poor glycemic control is associated with the increase in urine glycine betaine, carnitine, acetyl-carnitine and RBP excretion in diabetic patients. However, < 50% of the observed increase in glycine betaine excretion has been accounted for by the variables measured, suggesting other unidentified processes may also be involved.

Adult↗
PubMed1999

Cerebrovascular disease as a general medicine discharge diagnosis: assessment of diagnostic agreement on case note review.

BACKGROUND: Accurate clerical coding of discharge diagnoses is important partly because results may be used to derive a recommended costing for hospital length of stays (LOS). Some authors think that discharge coding undertaken by clinicians will result in less diagnostic misclassification than clerical coding. This presupposes a high degree of between-observer diagnostic agreement between clinicians. AIMS: To compare discharge coding undertaken by two general physicians, for patients receiving a clerical discharge code of cerebrovascular disease. The recommended LOS was then calculated from each observer's discharge codes using the Physicians Diagnosis Related Group Working Guidebook. RESULTS: Eighty-two cases were coded as stroke by the clerical coder. Both medical coders agreed with this diagnosis in 68 (83%) of these cases. The corresponding figure for cases coded by the clerical coder as transient cerebral ischaemia was 47% (32/68) agreement between all three observers. Correcting for chance agreement between medical observers using the kappa statistic, a value of 0.64 was obtained for the combined stroke and transient cerebral ischaemia discharges, suggesting moderate diagnostic agreement. Using the clerical coder's results, the mean recommended LOS for all cases of cerebrovascular disease over the study period was calculated at 6.68 days. The corresponding values for the two medical coders were 6.68 days and 6.75 days. CONCLUSIONS: Diagnostic agreement between clinicians was moderate. Consideration of alternative diagnostic possibilities and the difficulty in determining the duration of neurological deficit were the main reasons for diagnostic disagreement. The mean recommended LOS was similar, however, when comparing results from all three observers.

Adult↗
PubMed1998

A population-based study of bone mineral density in women with longstanding type 1 (insulin dependent) diabetes.

This study aimed to explore multiple determinants of BMD (bone mineral density) in 99 women with long-standing type 1 diabetes, recruited from a population based register of insulin users. BMD was measured using DEXA (dual energy X-ray absorptiometry) at the femoral neck and lumbar spine, age adjusted Z scores were calculated and results compared to those of healthy volunteers. The median age of diabetic subjects was 42 years and the median duration of diabetes was 27 years. BMD was positively associated with body mass index and height at both the lumbar spine and femoral neck. There was a positive association with oral contraceptive pill use and lumbar spine BMD, and peripheral vascular disease was negatively associated with femoral neck BMD. No correlation was seen with either age or duration of diabetes and absolute BMD values. Mean Z score at the femoral neck was -0.12 (95% confidence interval -0.37 to +0.12). At the lumbar spine, the corresponding value was -0.21 (-0.44 to +0.02). Pre- and post-menopausal values for the diabetic subjects and healthy volunteers were found to be similar. In summary, axial BMD values in subjects with long-standing diabetes were similar to those observed in healthy non diabetic populations.

Adult↗
PubMed1996

Self-reported changes in capillary glucose and insulin requirements during the menstrual cycle.

Perimenstrual changes in glycaemic control and insulin requirements have been reported in Type 1 diabetes. A population-based sample of 124 women with Type 1 diabetes, aged 18 to 40 years, were questioned regarding perimenstrual changes in their self-monitored capillary blood glucose and insulin regimen. Sixty-one percent of women noted perimenstrual changes in capillary blood glucose. The commonest pattern was a premenstrual rise in glucose. Thirty-six percent of all study participants were making adjustments to their insulin dose in response to these changes in capillary blood glucose. There was no statistical difference in the mean glycated haemoglobin of subjects making perimenstrual adjustments in insulin (79.1 mmol mol-1 haem) compared to subjects who noted cyclical capillary glucose changes but did not adjust insulin (73.0 mmol mol-1 haem). Sixty-seven percent of subjects taking the fixed dose oestrogen/progesterone oral contraceptive pill (OCP) noted perimenstrual changes in glucose. In summary, a third of the women surveyed made perimenstrual adjustments to their insulin dose, but there was no evidence to suggest that this behaviour was associated with improved glycaemic control. Use of the fixed dose combined oral contraceptive pill did not eliminate perimenstrual changes in glucose.

Adolescent↗
PubMed1996

Women and diabetes.

There is an increasing demand by women with diabetes for information on health issues such as pre-conception planning, contraceptive choices, hormone replacement therapy, and osteoporosis prevention. The risks and benefits of therapeutic approaches in these areas will be influenced by the presence of diabetes. Other health issues discussed in this article, which are unique to women with diabetes, include the effect of the menstrual cycle on glycaemic control and insulin requirements, and insulin omission in order to lose weight.

Adult↗
PubMed1996

Diabetes mellitus in older patients. Is tight blood glucose control warranted?

Diabetes mellitus is a major health problem in the older population, where it is mainly of the non-insulin-dependent type [i.e. non-insulin-dependent diabetes mellitus (NIDDM)]. Epidemiological evidence and extrapolation of trial data from patients with insulin-dependent diabetes mellitus (IDDM) suggests that improving glycaemic control reduces the risk of developing microvascular complications (i.e. retinopathy, nephropathy and neuropathy) and also slows the rate of progression of these complications in patients with early disease. Macrovascular morbidity and mortality is, however, more common than microvascular disease in the older population and the evidence that improved glycaemic control significantly reduces the impact of macrovascular disease is weak. Thus, the overall benefits of tight glycaemic control are less well defined in older patients, who tend to have NIDDM, than in younger patients with IDDM. There are small but significant risks associated with tight glycaemic control in the older patient, including potentially fatal hypoglycaemia with sulphonyl-ureas and/or insulin, and fatal metformin-induced lactic acidosis. Patients at especially high risk of these complications can, however, be identified and inappropriate pharmacological intervention can be avoided.

Age Factors↗
PubMed1995

Vaginal symptoms and insulin dependent diabetes mellitus.

AIMS: To assess the incidence of vaginal symptoms in younger women with insulin dependent diabetes, and also to assess the relationship between symptoms and other clinical risk factors for candidiasis. METHOD: A population-based questionnaire was administered to women aged 18-40 years with insulin dependent diabetes. Subjects were asked about symptoms of "vaginal thrush" as a surrogate question for symptoms suggestive of vaginal infection. Glycaemic control was assessed by measurement of glycated haemoglobin. (Non-diabetic reference range of 30-50 mmol/mol haem). RESULTS: One hundred and twenty-four out of 144 eligible women completed the questionnaire, a participation rate of 86%. Of the women interviewed, 60% had experienced one or more episodes attributed to "vaginal thrush", in the previous year. All seven subjects with a glycated haemoglobin of 100 mmol/mol haem or greater, experienced vaginal symptoms in the previous year. The relationship between frequency of vaginal symptoms and glycated haemoglobin was however weak. CONCLUSIONS: Vaginal symptoms are common in younger women with insulin dependent diabetes and are not confined to subjects with poor diabetes control. We recommend that health professionals caring for these women enquire about symptoms of vaginitis so that appropriate diagnosis and treatment can be initiated.

Adolescent↗
PubMed1994

Attitudes and knowledge regarding contraception and prepregnancy counselling in insulin dependent diabetes.

AIMS: To assess knowledge and attitudes of women with insulin dependent diabetes to contraception, prepregnancy planning, and genetic risk. METHOD: Women with insulin dependent diabetes, aged 18 to 40, were identified from a population-based register of insulin users in North Canterbury. Participating subjects underwent a structured face to face interview, assessing current contraceptive practices and their knowledge and attitudes to the areas outlined above. RESULTS: One hundred and twenty four women, representing 86% of eligible women, agreed to participate. Eighty five subjects were using some form of contraception. The most popular choices were the combined oral contraceptive pill (35%), the progesterone only pill (12%), condoms (24%), vasectomy (12%) and tubal ligation (12%). All subjects recognised the importance of good blood glucose control during pregnancy. Thirty nine percent of subjects using contraception avoided the combined oral contraceptive pill because of concerns about metabolic and vascular side effects. Only 52% of subjects knew the correct figure for genetic risk of passing insulin dependent diabetes on to an offspring. CONCLUSIONS: Patient education regarding the need for prepregnancy planning in women with insulin dependent diabetes appeared adequate and the percentage of subjects using contraception was higher than that described in overseas diabetic populations. Over a third of subjects were however concerned about the risks of contraceptive options in insulin dependent diabetes, particularly with regard to the use of the combined oral contraceptive pill. This finding suggests that discussion about the advantages and disadvantages of contraceptive choices should be an integral part of patient education for women with insulin dependent diabetes mellitus of child-bearing age. Knowledge about genetic risk was inadequate in half the subjects interviewed, and this area of patient education could also be improved.

Adolescent↗