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Biomedical subjects

H M Becker

Publications and source records attributed to H M Becker.

At least 55 records · Page 3Linked to original sources

[Peripheral aneurysms-frequency, etiology, and localisation (author's transl)].

Peripheral aneurysms (p.a.) took only 4% of the 8.461 reconstructive operations in vascular surgery (1966-March 15, 1981). 44% of the p.a. were secondary to arteriosclerosis, while 41% were anastomotic aneurysms. 2/3 of all arteriosclerotic peripheral aneurysms were localized in the iliac or femoral artery; the popliteal artery was involved in 25%. 25% of the patients had 2 and more aneurysms. The popliteal aneurysm was found to be bilateral in 32%. Rupture occurred only in 3.5% whereas 27% of all peripheral aneurysms were associated with distal occlusive disease. In the asymptomatic stage amputation rate was 4%, the operative letality 2%, after complications both increased up to 16%.

Adult↗

Stenosis of the supraaortic branches combined with coronary artery disease: one-stage surgical treatment.

Combined one-stage surgery of the supraaortic branches and the coronary arteries was performed on 17 consecutive patients, 13 men and 4 women, having a mean age of 56.7 +/- 8 years. Angina pectoris was the primary symptom in all patients. Signs of cerebro-vascular insufficiency were present in 4 cases, 2 with syncopies, one with amaurosis fugax, and one with drop-out symptoms. All patients were invasively examined. Coronary angiogram verified triple vessel disease in 13 cases, double vessel disease in 3 and single vessel disease in one. Angiography of the carotid artery proved unilateral disease in 11 patients, in 5 both sides were either stenosed or occluded. One patient had a left-sided proximal 80% lesion of the subclavian artery. In all cases, the supraaortic branches were done first, followed by revascularization of the coronary artery system. All patients survived the early postoperative course; one died suddenly 33 months after operation. After 16.8 +/- 14 months, 11 out of 15 patients felt much better. Signs of cerebro-vascular insufficiency were not present. Our conclusion: one-stage surgery of the supraaortic branches and the coronary arteries would seem justified. A list of indications is presented.

Adult↗

[Haemodynamic changes in infrarenal aortic aneurysm operations (author's transl)].

UNLABELLED: Haemodynamic changes after aortic cross-clamping were measured during operation of 11 patients suffering from infrarenal aortic aneurysm. Systemic vascular resistance, mean arterial pressure and pulmonary capillary wedge pressure are increased, while cardiac index is significantly decreased. Heart rate and right atrial pressure remain nearly unchanged. The elevations in systemic vascular resistance, mean arterial pressure and pulmonary capillary wedge pressure are reversed by continuous nitroglycerin infusion, cardiac index is increased. CONCLUSIONS: 1. meticulous haemodynamic monitoring is very important in operations including abdominal aortic cross-clamping in order to prevent imminent cardiac complications. 2. the haemodynamic changes induced by aortic cross-clamping can be reversed by infusion of nitroglycerin.

Aged↗

[Traumatic renal vein thrombosis].

Two female patients with left renal vein thrombosis are reported. In one case, the thrombosis was induced by preoperative selective renal vein phlebography for diagnosis of a perirenal tumor. The thrombosis was then detected intraoperatively. In the other case, the thrombosis was caused by traumatic avulsion. Predominantly, left renal vein thrombosis is treated conservatively. Both patients were operated, however. The operation of the first patient was indicated because of the operative tumor therapy. Relaparotomy of the second patient led to nephrectomy due to kidney contusion.

Adult↗

Tissue pO2 and transcutaneous pO2 as guidelines in experimental and clinical drug evaluation.

Tissue pO2 measurements on skeletal muscle surface both in patients and in animals in a model of occlusive disease revealed local tissue hypoxia that, until now, had not been detected with any other method. This kind of local tissue hypoxia is interpreted as a disturbance of local microflow distribution in the presence of unchanged regional blood flow rate. In response to buflomedil infusion, tissue pO2 histograms improved without any change in regional blood flow or distal blood pressure. In comparison to healthy volunteers, transcutaneous pO2 measurements in patients allowed establishment of of tcpO2 profiles along the lower extremity which were in agreement with angiographic localization of vessel occlusion. In a preliminary study, buflomedil infusion (3 mg/kg) over 30 minutes caused a significant increase in tcpO2 in 5 patients in the absence of any significant change of segmental blood pressure. It is concluded that both tissue pO2 and tcpO2 measurements are able to provide unique information about local changes of the microcirculation in occlusive vessel disease.

Animals↗

[Extracranial carotid stenosis and its sonographic diagnosis].

The direct Doppler examination of the carotid arteries as a method to detect and distinguish stenoses and occlusions of the common, internal, and external carotid arteries allows to decide on operability and indication for surgical treatment. The exact observation of the acoustical flow signals permits to a high degree an identification of even small stenoses and arteriosclerotic plaques. In 125 angiographical controls 95% of the sonographic diagnoses, in stenoses larger than 50% correct diagnosis could be established even up to about 99%. There were no false positive sonographic findings. Because of our good results we did not consider it necessary in recent time to perform an angiography before surgery in 25 patients. These patients had a high angiographic risk and there was a clear cut Doppler finding of an extreme stenosis in the internal carotid artery.

Carotid Artery Diseases↗

Preserved human umbilical cord veins in reconstructive surgery of peripheral arteries. Clinical experience and preliminary results.

Preserved human umbilical cord veins were used in 66 patients during 67 reconstructive interventions for replacement of arteries with a small diameter, in various anatomic sites. This includes 28 reinterventions (41.8% of the cases) after previous vascular surgery. In our predominantly negative selection of patients, 24 grafts were occluded within 3 months postoperatively, but some of these could be reopened successfully. Twelve more grafts were occluded by thrombosis up to one year after surgery. Taking into account the successful revisions, 62.5% out of 50 femoro-popliteal reconstructions were functioning one year after surgery. We therefore conclude that when an autogenous vein is no longer available, the use of glutaraldehyde-preserved human umbilical vein may thus be indicated for reconstructions extending beyond a joint.

Adult↗

A new operative technique for kinking stenoses of the internal carotid artery.

A method of carotid artery plication for kinking stenoses of the internal carotid artery is described. This method has been used in 13 symptomatic patients with type III kinking up to now. Satisfactory long-term results were obtained in 11 patients, one patient had to be reoperated for postoperative stenosis and one patient died after the operation from ischemic cerebral injury. It is concluded that the method is a suitable alternative to resection procedures, particularly in cases of kinking and arteriosclerotic stenosis.

Aged↗

Extracranial aneurysms of the carotid artery.

Aneurysms of the extracranial carotid artery represent a serious disease because of possible cerebral embolism and aneurysm rupture. Between 1960 and 1979, 28 aneurysms of the extracranial carotid artery were seen in 27 patients at our institution. Twenty-six of these patients noticed a pulsating tumor, 12 patients had neurological symptoms; 2 aneurysms were ruptured. Five times the external carotid artery, and 3 times the internal carotid artery were ligated without neurological symptoms. After aneurysm resection, the carotid artery was reconstructed in 4 cases by direct suture, and in 2 cases by patch angioplasty. Reconstruction was accomplished with a tube-graft in 9 instances, once an extra-intracranial shunt had to be performed in advance. Two patients developed neurological deficiencies after the operation (8.7%), in one of them these were permanent. In the follow-up, 20 patients were without symptoms (87%), 3 patients died after the operation (peri-operative mortality 13%). Out of the 5 non-operated patients 2 died after a short time: one of an acute myocardial infarction and one of an extensive cerebro-vascular infarction. Two patients with asymptomatic internal carotid aneurysm refused the operation and are without symptoms for 2 and 40 years respectively. Because of the potential risks of cerebro-vascular infarction and aneurysm rupture, good results of operative treatment call for an aggressive surgical approach in dealing with extracranial carotid aneurysms.

Adult↗

[Hemodynamic response to surgery of infrarenal aortic aneurysm (author's transl)].

Hemodynamic changes after aortic cross-clamping were measured during operation of 11 patients suffering from infrarenal aortic aneurysm. Systemic vascular resistance, mean arterial pressure and pulmonary capillary wedge pressure are increased, while cardiac index is significantly decreased. Heart rate and right atrial pressure remain nearly unchanged. The elevations in systemic vascular resistance, mean arterial pressure and pulmonary capillary wedge pressure are reversed by continuous nitroglycerin infusion, cardiac index is increased. It is concluded that a meticulous hemodynamic monitoring is very important in operations including abdominal aortic cross-clamping in order to prevent imminent cardiac complications.

Aged↗