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Biomedical subjects

H M Bernstein

Publications and source records attributed to H M Bernstein.

7 recordsLinked to original sources
PubMed2001

Administration of recombinant granulocyte colony-stimulating factor to neonates with septicemia: A meta-analysis.

A meta-analysis was used to determine whether administering recombinant granulocyte colony-stimulating factor (rG-CSF) to neonates with bacterial septicemia reduces mortality. Five studies were identified, involving 73 rG-CSF recipients and 82 control subjects. Mortality was lower among the rG-CSF recipients (odds ratio, 0.17; CI, 0.03-0.70; P <.05). However, when the non-randomized studies were excluded, the P value was.13. For the subgroups "<2000 g" or "neutropenia," the P value was <.02. Thus the routine use of rG-CSF cannot be recommended for all neonates with sepsis.

Granulocyte Colony-Stimulating Factor↗
PubMed1990

Dynamic skinfold thickness measurement in infants fed breast-milk, low- or high-sodium formula.

A stratified sample of normal infants born at term at Johannesburg Hospital, who attended the hospital for a routine 6-week follow-up visit, were selected to include 43 infants who were exclusively breast-fed, 42 fed a low-sodium formula and 39 fed a high-sodium formula (greater than 10 mmol sodium/l). Dynamic skinfold thickness measurements (DSTM), designed to assess the amount of interstitial fluid, were performed on each infant by the application of a skinfold caliper for a 3-second sampling period at two sites. The curves generated by these applications were recorded and analysed by microcomputer. There were no differences between any of the feeding groups for DSTM measurements of blood pressure suggesting that the range of sodium ingested by these groups of infants had no significant effects on extracellular water content. However, using multiple linear regression, both DSTM and blood pressure were best predicted by body weight and not by age or any other anthropometric measurement. Thus the normal postnatal decrease in extracellular fluid volume and increase in blood pressure appears to be most closely related to an increase in body weight.

Animals↗
PubMed1990

Short-term outcome for very-low-birth-weight infants with prolonged oxygen requirement.

Although Johannesburg Hospital's neonatal intensive care unit's survival rates are similar to those of First-World countries, it has been the impression of ward staff that ventilated very-low-birth-weight (VLBW) infants who cannot be weaned from high concentrations of oxygen and/or high inflation pressures within 7-10 days constitute a group with a poor prognosis. This study confirms previous studies showing that the early neonatal mortality rate is twice as high as the late neonatal mortality rate. It also confirms that mortality is related to birth weight and peak pressure and shows that VLBW infants with high oxygen and pressure requirements after 1 week do indeed constitute an extremely high-risk group with a short-term morbidity rate of 70-80% and a mortality rate of almost 50%.

Humans↗
PubMed1988

Kawasaki disease.

Explore the source record for details and available documents.

Child, Preschool↗