Biomedical subjects

H M Bowers

Publications and source records attributed to H M Bowers.

3 recordsLinked to original sources

PubMed1979

Numbers of mast cells in the axillary lymph nodes of breast cancer patients.

This retrospective study of surgical specimens from forty-three consecutive patients treated by modified radical mastectomy for carcinoma of the breast shows that those patients surviving for at least sixty months after operation have a significantly greater number of mast cells in their axillary lymph nodes than the nonsurvivors (p less than .001). When expressed as cells/mm2 the survivors are associated with nodal concentrations greater than eleven mast cells per square millimeter while the nonsurvivors haver fewer than eleven mast cells/mm2. The results suggest that the number of nodal mast cells may be a readily quantitated host response of prognostic value in carcinoma of the breast.

Adult↗

PubMed1979

Distribution of mast cells in the axillary lymph nodes of breast cancer patients.

In a study of the pattern of distribution of mast cells in the axillary lymph nodes of 43 consecutive breast cancer patients it was observed that: 1) the pattern of distribution of mast cells in the survivors and nonsurvivors is similar, 2) there is almost complete absence of mast cells in the germinal centers with predominance of them in the T cell areas, and 3) a significant number of mast cells are seen in the afferent lymphatic route and the highest percentages of mast cells found in the medullary sinuses. The significance of these findings as they pertain to the relation of mast cells to the T cell system and to the migratory nature of mast cells is discussed.

B-Lymphocytes↗

PubMed1975

Phialophora mutabilis endocarditis.

This is the first reported case of fungal endocarditis due to vegetative growth of Phialophora mutabilis on a prosthetic mitral valve. The patient had rheumatic heart disease with mitral and aortic stenosis. Four months after the mitral and aortic valves had been replaced by prostheses the patient developed congestive failure. Because of increased left atrial pressure, the mitral prosthesis was replaced. A large matted obstructive fungal vegetation was found on the prosthesis. Culture of this vegetation grew Phialophora mutabilis. The patient died postoperatively, and at autopsy the fungus was not found in other tissues. Culturally and morphologically, P. mutabilis shows wide variation in pigmentation, colonial and microscopic appearance. Conidia formation from intercalary cells along the hyphae is somewhat similar to that of Aureobasidium spp. P. mutabilis was injected into mice. Mice pretreated with cortisone died 3 to 5 weeks after intraperitoneal inoculation, while the majority of untreated mice died within 20 weeks of inoculation.

Animals↗