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Biomedical subjects

H M Chapel

Publications and source records attributed to H M Chapel.

79 records · Page 5Linked to original sources
PubMed1976

Report of nine cases of accidental injury to man with Freund's complete adjuvant.

Nine cases of accidental injury with Freund's complete adjuvant to man are reported. One case is reported in detail and the other eight have been seen and reviewed retrospectively. Reactions developed in Mantoux positive individuals, who injected Freund's complete adjuvant with another protein. However, not all such injections produced the reaction. Treatment was unsuccessful, although one reaction may have been aborted by early surgical excision of the site of injection.

Accidents, Occupational↗
PubMed1974

The Rosette inhibition test in skin-grafted patients.

The rosette inhibition test was performed on lymphocytes from five patients who received viable allogeneic skin grafts after a severe burn injury. Serial tests were done to ascertain whether a change in the minimal inhibitory concentration of antihuman lymphocyte globulin needed to inhibit rosette formation by 25% was specifically associated with rejection of such a graft. No such change was observed.

Adolescent↗
PubMed1973

Rosette inhibition test in severely burned patients.

The rosette inhibition test has been advocated as a test of immune reactivity in patients given transplants. We have done the test in lymphocytes from patients with severe burns, non-burnt control patients, and normal subjects. There was no correlation with the period of immunosuppression which follows a severe burn, though both groups of patients showed a wider range of minimal inhibitory concentrations (M.I.C.) than the normal group. Wide day-to-day variation of M.I.C. in burn and control patients was noted; this seemed to correlate with the ratio of sodium to potassium excreted in the urine. In-vitro experiments suggest that the M.I.C. is correlated with a plasma constituent which may be similar in action to hydrocortisone and that the rosette inhibition test is not a direct measure of immune reactivity.

Alanine Transaminase↗