[Intelligence and aptitude tests for practicing physicians in the USA].
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Aptitude Tests↗
Biomedical subjects
H M Foy
Publications and source records attributed to H M Foy.
Antigenicity and reactogenicity of influenza A/USSR/77 virus vaccine in children--a multicentered evaluation of dosage and safety.
Clinical trials of monovalent A/USSR/77 (H1N1) and trivalent A/USSR/77 (H1N1), A/Texas/77 (H3N2), and B/Hong Kong/72 inactivated influenza virus vaccines were carried out in 358 children and adolescents. Only split-virus vaccines were administered to children younger than 13 years of age. No serious local or systemic reactions were observed among the study participants. Two doses of vaccine containing 7-20 micrograms of the A/USSR/77 (H1N1) viral antigen were required to achieve serum titers of hemagglutinin-inhibiting (HA1) antibody greater than 1:40. However, single doses containing 7-20 micrograms of the A/Texas/77 (H3N2) or B/Hong Kong/72 antigens stimulated serum HAI antibody levels of 1:40.
Adolescent↗
Comparison of ophthalmic silver nitrate solution and erythromycin ointment for prevention of natally acquired Chlamydia trachomatis.
During prospective studies of infants born vaginally to women with cervical Chlamydia trachomatis infection, we evaluated 27 infants given 0.5% erythromycin ointment and 93 given 1% silver nitrate solution as eye prophylaxis, according to the preference of the parents or delivery room personnel. The cumulative proportion of infants developing chlamydial conjunctivitis was 25% for both groups (P = 0.37, Mantel-Cox test). The cumulative proportion of infants developing chlamydial infection at any anatomic site was 74% for those given erythromycin and 70% for those given silver nitrate (P = 0.93). The two groups did not differ significantly in cumulative proportions developing nonchlamydial conjunctivitis. These results indicate that, as it is routinely used in our hospital, erythromycin ointment was not more effective than silver nitrate as prophylaxis against chlamydial conjunctivitis. The influence of delayed administration on efficacy of prophylaxis requires further evaluation.
Chlamydia Infections↗
Sexually transmitted diseases and tubal pregnancy.
The risk of tubal pregnancy associated with seropositivity to Chlamydia trachomatis or following a diagnosis of gonorrhea, genital herpes, trichomoniasis, genital warts, or nonspecific vaginal infection was evaluated in a study of this condition among women who were members of a prepaid health plan. A total of 264 women who had a tubal pregnancy between 1981 and 1986 were interviewed about their history of these sexually transmitted diseases (STDs). Their responses were compared to those of 715 women who were matched by age and county of residence but were otherwise randomly selected from the enrollment files of the health plan. Chlamydia antibody status was known in a sample of 135 cases and 192 controls. Although more cases reported a history of gonorrhea, trichomoniasis, and non-specific vaginal infections than did controls, only a modestly elevated risk for trichomoniasis remained after logistic regression was used to adjust for the effects of age, reference year, race, presence of contraception at reference date, seropositivity to Chlamydia trachomatis, and a history of other STDs. By contrast, among women for whom Chlamydia trachomatis antibody status was assessed, presence of antibody was associated with a two-fold increase in the risk of tubal pregnancy after adjusting for the effects of the previously enumerated variables. These findings confirm the relevance of Chlamydia trachomatis as a risk factor for ectopic pregnancy, and they also underscore the importance of adjustment for the influence of other STDs when evaluating the association between a specific STD and the occurrence of tubal pregnancy.
Adolescent↗
Chronic arsenic poisoning from well water in a mining area in Thailand.
Endemic arsenic poisoning manifested by palmoplantar keratoderma and hyperpigmentation was surveyed in a village in a tin and wolfram mining area in southern Thailand where two cases of Bowen's carcinoma had occurred. Nine percent of examined adults randomly selected from 58 households were found to have skin manifestations of arsenic poisoning. Also, children with typical palmoplantar keratoderma were recognized, the youngest being four years old. A seven-year-old with severe keratoderma also had neurological manifestations and appeared mentally retarded. Arsenic concentration in shallow wells varied between 0.02-2.7 mg/l (average 0.82), and piped water had 0.07 mg/l. A major source of the contamination of ground water probably was slag heaps positioned next to a stream that fed the village.
Adult↗
Epidemiologic aspects of M. pneumoniae disease complications: a review.
As early as the 1940s, erythema multiforme exudativum (Stevens-Johnson syndrome) and hemolytic anemia were associated with outbreaks of atypical pneumonia, a disease later found to be caused by Mycoplasma pneumoniae. Epidemiologic evidence has also associated neurological complications, especially aseptic meningitis and meningoencephalitis, with M. pneumoniae infections. Urticarial and morbilliform skin rashes often appear late in the course of M. pneumoniae pneumonia. A multitude of other complications have been ascribed to M. pneumoniae infections, often reported as case reports diagnosed by serologic antibody titers only. More systematic investigations are needed to assess the frequency of complications to M. pneumoniae infections. Isolation of the agent, not only serologic titer rises, should be required before a syndrome is attributed to M. pneumoniae infection.
Adult↗