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Biomedical subjects

H M Heinisch

Publications and source records attributed to H M Heinisch.

At least 19 recordsLinked to original sources
PubMed1978

[Animal experimental studies on liver morphology after intravenous administration of a fat emulsion].

In short infusion series run over a 5day period, a fat emulsion on the basis of soya oil with egg lecithin as emulsifier, has been applied to rabbits by the intravenous route in a dosage of 2 and 4 g/kg body-weight/day. The results changes to the liver morphology have been analysed histologically by light-microscope in a systematic manner; using standard intervals of one to fifteen weeks. The most conspicuous phenomenon of the changed liver morphology is a fatty degeneration of the Kupffer's cells of the liver, whose different degree of severity was determined semiquantitatively by determination of the so-called index of fatty degeneration. The loading of the reticulo-endothelial system (RES) of the liver is very heavy with the higher dose; it is lower with a dose of 2 g fat/kg body-weight. The histological changes recede only slowly. A simultaneous parenteral administration of carbohydrates did not result in any provable inferior loading of the RES.

Animals↗
PubMed1978

[Intraportal and intravenous administration of fat emulsions. Comparison of liver morphology in animal experiments].

In short infusion series run over 5 days, a fat emulsion on the basis of soya oil with egg lecithin used as emulsifier has been infused to rabbits by the intravenous and intraportal routes in a dosage of 2 and 4 g/kg bodyweight/day. By a light-microscopic analysis of the liver morphology after one and three weeks, mainly a fatty degeneration of the Kupffer's cells of the liver was found. It was considerably less conspicuous after endo-portal supply than after peripheric-intravenous supply--findings which became more obvious with the higher dose.

Animals↗