Biomedical subjects

H M Hofmann

Publications and source records attributed to H M Hofmann.

39 records · Page 3Linked to original sources

PubMed1986

Diagnosis and treatment of gestational diabetes according to amniotic fluid insulin levels.

In spite of dietary treatment, the infants of pregnant patients with abnormal glucose tolerance have hyperinsulinism and diabetogenic fetopathy in 10 to 36% of cases. Those patients, who require insulin to prevent from fetopathy cannot be reliably selected by maternal parameters such as blood glucose and glycosylated hemoglobin values. We recommend the measurement of amniotic fluid insulin between the 28 and 32 weeks of pregnancy to differentiate whether the fetus is compromised or not. Subjects with values above the 97th centile require insulin therapy. Inadequate insulin dosage or delayed fetal hyperinsulinism can be discovered by checking the amniotic fluid insulin level at 33 to 36 weeks. In a total of 88 gestational diabetic patients 19 had raised amniotic fluid insulin levels indicating the onset of diabetic fetopathy at an early stage. Diabetic patients with raised amniotic fluid insulin levels needed large doses of insulin, namely 64.6 +/- 29.5 (Mean +/- SD) U/24 h. This treatment reduced mean blood glucose levels from 98 +/- 9 (Mean +/- SD) mg/dl to 82 +/- 10 mg/dl and was sufficient to prevent from diabetic fetopathy.

Adult↗

PubMed1986

[Posterior uveitis in systemic diseases. A pathologic and epidemiologic study].

In the course of 2943 autopsies, during which the eyes were also removed, investigations were carried out concerning inflammatory lesions of the posterior uveal tract. Posterior uveitis was found in 202 cases (6.9%) of subjects whose mean age was 74.5 years. In 98% of the cases this was a non-granulomatous inflammation. The frequency of the associated systemic diseases in the cases of uveitis was compared with the frequency of such diseases in an accurately chosen control group. The results of our investigation showed that diabetes mellitus and inflammatory diseases, particularly rheumatoid arthritis, myocarditis, endocarditis and hepatitis are more frequently found in patients with uveitis.

Aged↗

PubMedDate not supplied

Continuous insulin delivery systems for the pregnant diabetic patient.

In highly unstable diabetes (brittle diabetes) the degree of metabolic control called for today in managing the pregnant diabetic patient is not achievable by intensified conventional insulin therapy. These cases have been markedly improved by continuous insulin delivery systems. In the course of 2 years, 6 diabetic pregnant patients (8%) were treated with insulin pumps for a total of 910 days, using the intravenous route once, the intraperitoneal route twice and the subcutaneous route three times. The group consisted of one White C, one White D and four White R diabetic patients. Metabolic control was achieved by 5,916 blood sugar measurements, 42 determinations of glycosylated hemoglobin (HbA1) and 19 determinations of amniotic fluid insulin. The intravenous and the subcutaneous route showed about the same rate of hypoglycemia as intensified conventional insulin therapy. Hypoglycemia did not appear, however, under intraperitoneal insulin administration. Mean blood glucose in patients on the pump dropped from 121.0 to 97.4 mg/dl. The standard deviation of the blood glucose values during one week dropped from 64.5 to 35.2 mg/dl, the mean amplitude of glycemic excursions (MAGE) from 100 to 43 mg/dl and the mean of daily differences (MODD) from 72 to 29 mg/dl. The concentration of glycosylated hemoglobin sank from 10.5 to 6.8%. The metabolic condition improved significantly. On average, the patients were hospitalized for 7.5 (1.7-12.8) weeks. Fetal hyperinsulinism developed in 2 patients on the pump and was reversible by closer metabolic management. Neonatal weight was in the normal range and there were no signs of diabetogenic fetopathy.

Adult↗