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Biomedical subjects

H M Markusse

Publications and source records attributed to H M Markusse.

At least 55 records · Page 3Linked to original sources
PubMed1992

Ophthalmological examinations of patients with primary Sjögren's syndrome selected from a rheumatological practice.

Ophthalmological examination of patients with primary Sjögren's syndrome (SS) (n = 44) taken randomly from a rheumatological practice revealed that in this population group the eyes were frequently but not seriously involved (n = 42). Primary SS patients (n = 44) could not be separated from patients suspected of primary SS, in whom the diagnosis had been excluded (n = 21) on the basis of ocular examination, but they were clearly distinguishable from healthy controls (n = 26). The diagnostic value of the tests currently in use to establish the diagnosis keratoconjunctivitis sicca in primary SS such as Schirmer's, tear film break up time and rose bengal staining tests appeared to be limited. These results demonstrate the heterogeneity of the syndrome, the influence of patient selection on patient characteristics in different primary SS populations and the limited value of using the present classification criteria for the diagnosis primary SS in individual patients.

Adult↗
PubMed1992

Beta 2 microglobulin in tear fluid from patients with primary Sjögren's syndrome.

beta 2 Microglobulin concentration in tear fluid was measured in 35 patients with primary Sjögren's syndrome (SS), in 28 normal control subjects matched for age and sex, and in 18 patients with arthralgias or myalgias and sicca complaints, in whom the diagnosis primary SS had been excluded. Increased beta 2 microglobulin concentrations were found in the patients with SS, but no correlation was found with the duration of the disease, age, or tear fluid production. Tear fluid beta 2 microglobulin determinations may be useful as an adjunctive diagnostic test for primary SS.

Humans↗
PubMed1992

A quantitative index derived from 99mTc-pertechnetate scintigraphy to assist in the diagnosis of primary Sjögren's syndrome.

A safe and simple technique is reported by which primary Sjögren's syndrome can be detected with a relatively high specificity and sensitivity. The method of serial scintigraphy has been used with reasonable success; however, the application of the linearity index as described here produced superior results. In 71 patients investigated, a sensitivity of 87% and specificity of 93% were recorded and make this the method of choice for evaluating patients suspected of having primary Sjögren's syndrome.

Humans↗
PubMed1992

Primary Sjögren's syndrome: clinical spectrum and mode of presentation based on an analysis of 50 patients selected from a department of rheumatology.

In this study we report on the clinical characteristics at the time of referral and during follow-up of 50 patients with primary Sjögren's syndrome (SS) in a rheumatological practice. The mean age of the patients at the time of diagnosis was 51.5 years. Four of them were men and 46 women. During a mean follow-up period of 9.1 yr (1-21 yr) from symptom onset the most common signs and symptoms were arthralgia (94%), complaints of dryness of the eyes (90%), mouth (82%) and skin (56%), weariness (64%), exanthema (48%), Raynaud's phenomenon (42%) and arthritis (42%). An elevated erythrocyte sedimentation rate (72%), elevated serum gammaglobulin (49%) and leucocytopenia (42%) were the most frequently encountered abnormalities of routine laboratory tests. After the initial hospital evaluation the diagnosis primary SS was made in only 10 (20%) of the patients. The diagnostic delay was on average 3.1 yr. Knowledge of the considerable heterogeneity of the disease may prevent extensive evaluations and provide better clinical care for patients with primary SS.

Diagnostic Errors↗
PubMed1991

Polyneuropathy as initial manifestation of necrotizing vasculitis and gangrene in systemic lupus erythematosus.

A patient with necrotizing vasculitis and systemic lupus erythematosus is reported. The vasculitis presented as a symmetrical sensorimotor axonal neuropathy and after three months it resulted in gangrene of a toe. Sural nerve conduction was abnormal and a biopsy of this nerve was diagnostic. Serum anti-endothelial cell antibodies were elevated during activity of the vasculitic process. Treatment with prednisone and cyclophosphamide induced a remission.

Adult↗
PubMed1990

Bisphosphonates in collagen arthritis.

Bisphosphonates suppress bone destruction in various diseases. We studied the effects of 3-amino-hydroxypropylidene-1,1-bisphosphonate (APD), and dimethyl-APD in the collagen model of chronic arthritis in rats. The incidence and severity of arthritis was not lower in rats treated with APD or dimethyl-APD compared with controls. The cellular and humoral immune responses to collagen were also similar in the treated and untreated animals. In all animal groups the same bone destruction was found radiographically 42 days after immunization. This study demonstrates that bisphosphonates do not suppress the course of collagen arthritis in rats.

Animals↗
PubMed1990

Rheumatoid discitis with cord compression at the thoracic level.

A 63-year-old man presented with spinal cord compression caused by rheumatoid discitis at a high thoracic level. Nuclear magnetic resonance imaging proved to be very useful in evaluating the extent of the inflammatory process. Early decompression and internal fixation resulted in cure with only some residual functional impairment.

Arthritis, Rheumatoid↗
PubMed1990

Eosinophilic fasciitis after allogeneic bone marrow transplantation.

We describe a patient with eosinophilic fasciitis (EF) developing 8 months after an allogeneic bone marrow transplantation for acute myeloblastic leukemia. The patient responded to low dose prednisone. A full thickness skin-muscle-fascia biopsy detected the characteristic fascial changes of EF and distinguished it from other forms of chronic graft-versus-host-disease (GVHD). This distinction may be important since EF after bone marrow transplantation may occur more often and it may respond to treatment with low doses of prednisone whereas chronic GVHD usually requires more extensive immunosuppressive treatment.

Bone Marrow Transplantation↗
PubMed1989

Unusual arthritis: be on the alert for leprosy.

A 50-year-old Indonesian man presented with arthritis of the left ankle, wrist and hand joints and a diffusely swollen left hand and foot. A few months later granulomatous skin lesions developed and renewed physical examination revealed a paresis of the intrinsic muscles of the left hand and the left M. extensor hallucis longes and thickening of several peripheral nerves. The skin lesions appeared to be anesthetic. A diagnosis of borderline tuberculoid leprosy was made and treatment resulted in cure with permanent peripheral nerve damage. This case emphasizes the importance of early recognition and treatment of leprosy to prevent nerve damage.

Arthritis↗
PubMed1989

Infectious arthritis caused by Klebsiella. A report of two cases.

Klebsiella arthritis is uncommon. This report describes 2 cases seen in one year in one hospital and reviews the previous 9 well-documented cases. Despite a long delay in diagnosis, antibiotic treatment without drainage procedures resulted in complete cure in one patient and cure with some impairment in the other.

Aged↗
PubMed1989

Anterior spinal artery syndrome in systemic lupus erythematosus.

We present a patient with systemic lupus erythematosus who developed an anterior spinal artery syndrome (ASAS) in association with livedo reticularis, leg ulcerations and thrombocytopenia. Low serum titres of anticardiolipin antibodies were detectable throughout the course of this disease. The patient recovered from the first episode of ASAS under corticosteroid treatment but remained paralytic after a second episode. Repeated magnetic resonance imaging of the spinal cord failed to show altered signal intensity.

Adolescent↗
PubMed1989

Infectious arthritis caused by Propionibacterium acnes: a report of two cases.

Propionibacterium acnes, a micro-organism with low pathogenicity, rarely causes arthritis in a joint without a prosthesis. This report deals with two cases of P acnes infectious arthritis probably caused by direct penetration of the micro-organism into the joint space during arthrocentesis, despite the use of strict disinfection procedures. P acnes isolated from synovial fluid cannot be dismissed as a bothersome contaminant without due consideration of the clinical status of the individual patient.

Adult↗
PubMed1989

Rheumatoid arthritis with eosinophilic fasciitis and pure red cell aplasia.

A case of longstanding rheumatoid arthritis with concurrent development of eosinophilic fasciitis and pure red cell aplasia is described. A simultaneous occurrence of all 3 disorders has not been reported. Treatment with moderate dosages of prednisone resulted in a prompt and complete remission of both the fasciitis and the selective marrow aplasia.

Arthritis, Rheumatoid↗
PubMed1989

Imaging of inflammatory arthritis with technetium-99m-labeled IgG.

The accumulation of nonspecific polyclonal human immunoglobulin G (IgG) radiolabeled with 99mTc was compared to that of [99mTc]albumin and [99mTc]nanocolloid in rats with collagen induced arthritis. Serial scintigrams were acquired directly, 4 and 24 hr after injection. A clearly discernable image of the site of synovitis was seen with [99mTc]IgG as early as 4 hr postinjection. The relative intensity of the inflammatory lesion was maximal at 24 hr. Discrimination between arthritic and nonarthritic joints as well as correlations between the relative intensity of the arthritic joint and clinical indices of joint inflammation were superior with IgG compared to albumin or nanocolloid. These studies show that localization and severity of inflammatory joint disease can be detected with radiolabeled nonspecific IgG.

Animals↗