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Biomedical subjects

H M Myers

Publications and source records attributed to H M Myers.

At least 19 recordsLinked to original sources
PubMed1987

Structure-activity relationships (SAR) of hydroxyapatite-binding molecules.

Carboxyl-containing molecules can bind to HA with sufficient affinity to prevent the uptake of AZ by this mineral. Structural features that favor binding can be discerned. Isolated carboxyls are inactive; adjacent dicarboxylic functions are marginally active. Crowding of oxygens in the form of vicinal carboxyls or hydroxyls contributes the property of HA binding ability. This property exhibits gradation in magnitude and the variation can be correlated with structural features of the carboxyl-containing molecule. Phospho functions are generally more powerful contributors to HA binding property than are carboxyls.

Adsorption↗
PubMed1983

IR absorption spectrophotometric analysis of the complex formed by tetracycline and synthetic hydroxyapatite.

The infrared (IR) spectra of KBr pellet preparations of tetracycline (TC) complexes with hydroxyapatite (HA) indicated that the binding of the antibiotic to bone mineral can occur independently at each of two ligands. The shifts in the IR spectrum occur for the keto-enol ligand of rings B and C and for the tricarbonylmethane grouping of ring A. Analogs that lack one or the other of these groups are able to form complexes with HA in which the common portion resembles that of the parent molecule.

Chemical Phenomena↗
PubMed1983

Dose-response relationship between water fluoride levels and the category of questionable dental fluorosis.

There is a dose-response relationship between the prevalence of the questionable category of dental fluorosis as reported by various authors and the drinking water fluoride level. While the possibility that chance could have produced this trend cannot be conclusively ruled out, a distinct pattern of increasing prevalence with increasing water fluoride level can be discerned. Such a pattern is not compatible with the concept of a threshold level for the action of fluoride ion on the enamel organ.

Dose-Response Relationship, Drug↗
PubMed1982

Orientation of adsorbed alizarin red S on hydroxyapatite.

Adsorption isotherms of alizarin red S on hydroxyapatite were supplemented with additional data to provide a simple model of adsorption. The model treats the adsorbing surface as a mosaic of unit cell a-c faces which have an area of 65 A2 each. The adsorbate of the model has molecular dimensions consistent with a 1:1 relationship between adsorbate and adsorption site. By comparing slurries of hydroxyapatite which differed by a factor of 4 in surface area of the solid, it was found that the isotherm based on edge-on adsorption was best simulated by the model. A method for compensating for differing degrees of surface coverage is described.

Adsorption↗