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H M Peck

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The effect of cyproheptadine on the chromosomes of human lymphocytes in vitro.

The effect of 4-[5-dibenzo(alpha,alpha)-cyclohepten-5-ylidene]-1-methylpiperidine (cyproheptadine, Periactinol) on the chromosomes of human lymphocytes in vitro was investigated. Cell cultures that had been established for 48 h from lymphocytes obtained from the peripheral blood of four volunteers were exposed for an additional 24 h to drug concentrations of 2.54 X 10(-5), 5.09 X 10(-5), 1.02 X 10(-4), or 2.03 X 10(-4) Mol/l. No variations or aberrations were seen in the chromosomes of human lymphocytes that could be definitely related to treatment with cyproheptadine.

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