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Biomedical subjects

H M Snow

Publications and source records attributed to H M Snow.

At least 55 records · Page 3Linked to original sources
PubMed1974

The effects of three beta-adrenoceptor blocking drugs on isolated preparations of skeletal and cardiac muscle.

1 The effects of propranolol, oxprenolol and practolol on the isometric twitch responses to electrical stimulation of isolated diaphragm muscles from the rat and of isolated papillary muscles from the rabbit are described.2 Depression of the twitch responses of the diaphragm muscle was produced by propranolol (20 mug/ml), by oxprenolol (100 mug/ml) and by practolol (500 mug/ml).3 Depression of the twitch responses of the papillary muscles was produced by propranolol (20 mug/ml) by oxprenolol (100 mug/ml) and by practolol (200 mug/ml).4 No increase of twitch tension was produced by oxprenolol or practolol on either tissue.5 It is concluded that propranolol, oxprenolol and practolol produce negative inotropic actions on isolated cardiac muscle by a mechanism unrelated to blockade of beta-adrenoceptors and which occurs at doses which are well in excess of those doses required to produce beta-blockade.

Adrenergic beta-Antagonists↗
PubMed1974

Left atrial receptors and the antidiuretic hormone.

1. Stimulation of left atrial receptors by distending balloons located at the junction between the pulmonary veins and the left atrium and in the body of the left atrium resulted in a diuresis in anaesthetized dogs.2. In the same dogs the diuresis was not consistently associated with a reduction in the antidiuretic activity of plasma as compared with that during the initial control period. The antidiuretic activity of dog plasma was assayed in water-loaded rats anaesthetized with ethanol.3. Intravenous injections of vasopressin suppressed a water diuresis in water-loaded dogs anaesthetized with chloralose. The changes in antidiuretic activity of dog plasma which resulted from these injections were reliably detected by the bio-assay in the rat.4. It is concluded that the diuretic response to the stimulation of left atrial receptors is not accompanied by a reduction in the plasma antidiuretic hormone level.

Anesthesia↗
PubMed1973

Chronotropic and inotropic effects on the dog heart of stimulating the efferent cardiac sympathetic nerves.

1. The chronotropic and inotropic responses of the dog heart to stimulation of the ansae subclaviae were studied.2. The maximum rate of rise of pressure in the left ventricle (dP/dt max) was used as an index of the inotropic changes.3. In experiments in which the secondary inotropic effects of changes in heart rate and blood pressure were prevented it was shown that, using stimuli which produced the same chronotropic response, stimulation of the left ansa subclavia resulted in an inotropic change which was about eight times greater than that which resulted from stimulation of the right ansa subclavia.4. In experiments in which heart rate and blood pressure were allowed to change freely it was shown that the secondary inotropic effects of changes in blood pressure and heart rate amounted to about 70% of the total inotropic change when the right ansa subclavia was stimulated and about 20% of the total change when the left ansa subclavia was stimulated.

Animals↗
PubMed1973

The inotropic effect on the heart of stimulating the vagus in the dog, duck and toad.

1. The chronotropic and inotropic effects of stimulating the vagus on the hearts of the dog, duck and toad were studied.2. The maximum rate of rise of pressure in the left ventricle (dP/dt max) measured at a constant heart rate and mean aortic pressure was used as an index of the inotropic changes.3. The sensitivity of dP/dt max as an index of inotropic changes brought about by stimulating the vagus was established in the toad where a 49% reduction in heart rate was associated with a 30% reduction in dP/dt max.4. In the dog stimulation of the vagus resulted in a reduction in heart rate of 38% and only a small reduction in dP/dt max of 6%.5. Results similar to those found in the dog were obtained in the duck where the reduction in heart rate of 44% was associated with reduction in dP/dt max of only 3%.6. It is concluded that the vagus has only a small and negligible negative inotropic effect on the ventricles of the dog and duck.

Animals↗
PubMed1973

Effect of stimulating right atrial receptors on urine flow in the dog.

1. Complex unencapsulated nerve endings (right atrial receptors) have previously been found in the endocardium of the right atrial appendage and the junction between the superior vena cava and the right atrium.2. Distension of balloons located in the right atrial appendage and at the junction between the superior vena cava and the right atrium resulted in an increase in urine flow. This diuresis was accompanied by a small increase in the excretion of sodium.3. Cooling the right cervical vagus caused a reduction in the response to distension of the right atrial appendage.4. It is concluded that stimulation of right atrial receptors by the distension of balloons located in the right atrial appendage and at the junction between the right atrium and the superior vena cava results in a reflex increase in urine flow.

Animals↗