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Biomedical subjects

H M Spinelli

Publications and source records attributed to H M Spinelli.

At least 19 recordsLinked to original sources

The vessel loop shoelace technique for closure of fasciotomy wounds.

Compartment syndrome of the extremity may occur after severe trauma secondary to fractures, vascular ischemia, crush, or electrical injury. Treatment consists of expedient fasciotomy to avoid permanent injury to muscles or nerves. Management of the wounds postoperatively has consisted traditionally of primary closure, healing by secondary intention, or split-thickness skin grafting to cover defects. The fasciotomy wound may remain substantial secondary to soft-tissue swelling and edema. The authors present an alternative protocol for fasciotomy wound management, consisting of gradual closure with progressive tension using vessel loops. The vessel loops are placed intraoperatively during the compartment release and are attached to the wound margins using standard skin staples. The loops are tightened progressively postoperatively during routine dressing changes, resulting in closure of the wound within 2 weeks. The advantages over split-thickness grafting include avoidance of donor morbidity and better cosmesis. Sporadic case reports using similar techniques have been published in the orthopedic literature with comparable results. The current series includes 37 patients, ages 9 to 48 years, who were treated for open fasciotomy. There were 11 upper extremity and 26 lower extremity wounds treated, all of which were closed within 3 weeks.

Adolescent↗

Reconstruction of upper cranial and cranial base defects utilizing the scalping flap.

Reconstruction of midfacial defects by means of a scalping flap has been widely practiced and described in the literature. The advantages of the flap are familiar to surgeons who perform extirpations and reconstruction of the head and neck and include contiguous availability, simplicity of application, and a robust and redundant blood supply. Despite these merits, the flap has not been widely used for reconstructions of large anterior cranial defects or defects of the cranial base. A retrospective review of 11 patients who underwent reconstructions between 1990 and 1995 was performed. In each case, a reconstruction of a large anterior cranial or cranial base defect was carried out. The resulting soft-tissue defect was restored via the scalping flap. In six cases, this was carried out in a single procedure. In five cases, flap division and insetting were carried out in a subsequent procedure, following a 1- to 2-week delay. In all cases, the extirpation and reconstruction were well tolerated, and the average time of hospitalization was 5.9 days and ranged from 3 to 11 days. No major surgical complications occurred. One of 11 patients had a minor complication not requiring surgical intervention. There was one recurrence of a cranial base tumor approximately 2 years following the initial resection and reconstruction. In all cases, the final aesthetic and functional results were acceptable to excellent. Follow-up ranged from 11 months to 5 years. In conclusion, the scalping flap can be effectively utilized for soft-tissue coverage in the reconstruction of anterior cranial and cranial base defects. Use of this simple and versatile flap in craniofacial reconstruction is well tolerated and is associated with a low morbidity, a good aesthetic result, and a short hospital stay.

Adult↗

Reconstruction of the orbit.

There are numerous methods for reconstruction of the orbit. The choices depend on the patient's age, the type of tumor, and the specific anatomic and functional demands required. Three-dimensional reconstructions, including bone and soft-tissue, and the particular needs of the ocular system must be considered, especially when subtotal or globe preservation procedures are used.

Humans↗

Current treatment of post-traumatic deformities. Residual orbital, adnexal, and soft-tissue abnormalities.

Evaluation and treatment of residual post-traumatic deformities of the periorbital region are approached best by systematically dividing the area into zones and assessing the deformities and needs of that particular region before addressing restoration of both function and cosmesis. These zones can be extended three dimensionally, and all abnormalities can be addressed appropriately. Bone malpositioning must be addressed first, and once repositioned, many soft tissue abnormalities may not require treatment. All periocular zones contain specialized structures that are interrelated. A fundamental understanding of the anatomy and physiology combined with the basic plastic surgical concept of recreation of the defect can lead to a successful approach to late deformities in this region.

Eye Abnormalities↗

Frequent clones of p53-mutated keratinocytes in normal human skin.

The multiple genetic hit model of cancer predicts that normal individuals should have stable populations of cancer-prone, but noncancerous, mutant cells awaiting further genetic hits. We report that whole-mount preparations of human skin contain clonal patches of p53-mutated keratinocytes, arising from the dermal-epidermal junction and from hair follicles. These clones, 60-3000 cells in size, are present at frequencies exceeding 40 cells per cm2 and together involve as much as 4% of the epidermis. In sun-exposed skin, clones are both more frequent and larger than in sun-shielded skin. We conclude that, in addition to being a tumorigenic mutagen, sunlight acts as a tumor promoter by favoring the clonal expansion of p53-mutated cells. These combined actions of sunlight result in normal individuals carrying a substantial burden of keratinocytes predisposed to cancer.

Adult↗

The latissimus dorsi perforator-based fasciocutaneous flap.

The latissimus dorsi musculocutaneous flap has proven utility in the reconstruction of defects of the breast, chest wall, head and neck, and upper extremity. As a free flap, the latissimus dorsi has become a mainstay for the coverage of severe traumatic tibial/ fibular wounds. We describe a new and useful extension of the latissimus dorsi musculocutaneous unit that consists of a fasciocutaneous segment based on musculocutaneous perforators from the thoracodorsal artery. The vascular anatomy of the flap is described and illustrated with 6 fresh human cadaveric dissections. We also present 3 cases in which in vivo dissections of this flap were performed, 2 at the time of latissimus microvascular transfer and 1 approximately 5 days after microvascular transfer to salvage exposed fractured tibial bone successfully due to distal muscle loss. A pedicled or free latissimus dorsi musculocutaneous flap may be reliably extended and thereby rendered more versatile through the use of the perforator-based fasciocutaneous flap. Benefits and potential applications of the latissimus dorsi perforator-based fasciocutaneous flap are discussed.

Child↗

Cranial plate and screw fixation in infancy: an assessment of risk.

Sixty-seven surgeons, members of the International Craniofacial Surgery Society, responded to a questionnaire focused on assessing the incidence and risk of cranial plate and screw translocation intracranially in infants undergoing cranial surgery. Despite screws, plates, and wires being evident intracranially in individual cases, no apparent increase in seizure frequency or susceptibility to head trauma was noted in this preliminary study.

Bone Plates↗

Reconstruction of the cranial base.

The cranial base is a complex boundary between intracranial and extracranial anatomic structures. Adequate reconstruction of the basicranium depends on the location, size, and nature of the defect. A reconstructive ladder can be built on a few basic principles: coverage of vital structures, separation of the intra- and extradural spaces, procedural simplicity, and aesthetics. Individual consideration should be given to reconstruction of bone, soft tissue, dura, and cerebrospinal fluid spaces.

Adult↗

Symptomatic lacrimal duct diverticulum associated with closed nasal fracture.

Diverticula of the nasolacrimal collecting system are rare. Their cause may be congenital, inflammatory, or traumatic. A diverticulum of the nasolacrimal duct that presented 26 years after nasal trauma is described. The location of this diverticulum is extremely uncommon, and a case occurring after closed nasal trauma has not yet been presented. Evaluative studies and pertinent anatomy are reviewed. In any patient with recurrent dacryocystitis after nasal fracture, the diagnosis of a lacrimal system diverticulum should be considered. A detailed history and physical examination combined with dacryocystography can be confirmatory. Treatment should consist of surgical exploration with a nasolacrimal system bypass procedure.

Adult↗

Orbital venous approach to the cavernous sinus: an analysis of the facial and orbital venous system.

Carotid-cavernous fistulas are abnormal communications between the internal carotid artery and the cavernous sinus produced by a rupture of the wall of the carotid artery or one of its branches into the sinus. Extradural branches of the internal or external carotid arteries may communicate with the cavernous sinus, producing proptosis, progressive glaucoma, and ocular vascular engorgement. Various approaches to obliterate these fistulas have evolved, many of which carry high morbidity or are precluded by anatomical considerations. Analysis of the venous anatomy of the orbit and face, including human cadaver dissections, reveals a new and safe approach to the cavernous sinus, requiring microsurgical isolation and cannulation of the superior ophthalmic vein through an anterior orbital approach. Selective embolization of a carotid-cavernous fistula can be performed successfully through this route. We present pertinent anatomy and technical considerations and the successful clinical application of these principles. Surgeons familiar with craniofacial anatomy and microvascular techniques can apply these principles and play an active role in the treatment of these complex problems.

Aged↗

Nasopalatine duct cysts and the role of magnetic resonance imaging.

Nasopalatine duct cysts are a common etiology for anterior midline palatal masses, which may be seen by craniofacial surgeons. Plain radiographs, computed tomography, and magnetic resonance imaging (MRI) scans may be useful in their diagnoses. Clinically, they may be symptomatic in more than 70% of patients. Treatment is surgical excision, with a recurrence rate of approximately 10%. We present a case of a midline, palatal mass in a 13-year-old girl in whom an MRI scan was utilized and evaluated as a radiological tool in the diagnosis and treatment plan of a nasopalatine duct cyst. An MRI scan is useful diagnostic tool; it provides exceptional definition of the anatomy in this region. A critical review of the literature, as well as pathogenesis and treatment recommendations, are provided.

Adolescent↗

An analysis of extradural dead space after fronto-orbital surgery.

This study was undertaken to evaluate several concerns regarding the extradural space resulting from elective fronto-orbital advancement or frontal sinus cranialization techniques. The questions are (1) Do infants undergoing these techniques have the potential to obliterate this space at an accelerated rate, e.g., within 1 or 2 days? (2) Do adults have any potential to obliterate the space? (3) Do children obliterate the space like infants or like adults? (4) What is the specific time sequence for dead-space obliteration? Twenty patients ranging in age from 6 months to 35 years were studied before and after fronto-orbital advancement. The patients were divided into three groups: (1) infants (up to 15 months), (2) children (up to 9 years), and (3) adults (9 years and beyond). Postoperative intracranial dead space was assessed by serial CT scans. Ten patients had CT scans more than 14 days after surgery. These data demonstrate that intracranial dead space in infants is obliterated in a delayed fashion. Children tend to obliterate intracranial dead space in a manner similar to that of infants. Adults are able to obliterate the space over a longer, but finite, period of time as compared with infants and children. Part of the mechanism responsible for obliteration of the postoperative space may be enlargement of the ventricular system.

Adolescent↗

Massive orbital teratoma in the newborn.

Teratomas are rare germ cell tumors that comprise approximately 1% of orbital tumors in childhood. Review of the world literature revealed only 51 well-documented patients with true congenital orbital teratomas. We present a newborn girl with a massive orbital teratoma that caused significant orbital enlargement with inferior and lateral displacement of the zygoma and a thinning of the orbital roof. The ipsilateral maxilla and palate were depressed inferiorly. No bony invasion was seen despite its massive size. A craniofacial approach was used to safely and completely extirpate this tumor. Histological sections demonstrated derivatives of all three germ cell layers. Recommendations for definitive treatment and a review of the literature are presented.

Female↗

Congenital ear deformities.

External ear deformities by themselves do not require emergent treatment, but associated abnormalities need to be defined to enable long-term planning. The pediatrician can orchestrate the specialists and keep parents and patient informed maximally.

Child↗

Periocular reconstruction: a systematic approach.

The records and photographs of 90 patients who underwent reconstructive procedures on the eyelids, canthi, and periocular tissues between 1982 and 1988 were reviewed retrospectively. The defects created by either fresh tissue histologically controlled resection or primary excision were analyzed according to location, size, and degree of resection and visual status. Histologic types included nodular, morphea, and fibrosing basal cell carcinomas; well to poorly differentiated squamous cell carcinoma; and melanoma in situ. The adequacy of both ocular protection and tissue preservation was assessed between 1 and 6 years postoperatively. Anatomic as well as functional reconstructions were performed with a complication rate of 12 percent. There were two tumor recurrences requiring extensive craniofacial extirpation and reconstruction. A systematic method of classifying periocular defects was developed in order to analyze various reconstructive options as well as the type and frequency of complications encountered. This classification system is applicable to primary benign and malignant lesions as well as defects. Analysis of patients who underwent periocular reconstruction in the context of this classification system reveals that larger defects and those involving the medial canthus are more prone to complications. Recurrent complications in the medial and lateral canthal region underscore the necessity of routinely utilizing ancillary procedures such as lacrimal intubation and canthopexy. Recommendations for periocular reconstruction are suggested based on this classification system.

Aged↗

Human bites of the eyelid.

Five patients with traumatic colobomas of the eyelid secondary to human bites were surgically repaired with retrieved autogenous tissue. All patients were treated with prophylactic intravenous antibiotics. Surgical repair consisted of debridement of the autograft, meticulous layered closure of the autograft to the wound, and placement of a lid margin suture. In two of the patients, mild upper eyelid retraction was noted, and two patients had loss of cilia.

Adult↗