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Biomedical subjects

H Mølgaard

Publications and source records attributed to H Mølgaard.

42 records · Page 3Linked to original sources
PubMed1990

Importance of abstention from alcohol in alcoholic heart disease.

A case of alcohol-associated heart disease, presenting with congestive heart failure, was followed for 36 months. After abstinence from alcohol, fractional shortening rose from 13 to 60%. After 1 1/2 years of abstinence and normal physical capacity, the alcoholic abuse was resumed. Eleven months later, the patient was again in overt heart failure. Withdrawal of alcohol was again associated with significant clinical improvement, but despite being in functional NYHA class I, fractional shortening only increased from 14 to 29%. Endomyocardial morphology was unrelated to the severity of the disease. Alcoholic heart disease is partially reversible, but total abstinence is necessary to preserve cardiac function.

Adult↗
PubMed1989

Minimal heart rates and longest pauses in healthy adult subjects on two occasions eight years apart.

A 24-h Holter monitoring (HM) record was obtained on two occasions 8 years apart in 183 healthy subjects (120 male and 63 female), aged 40-85 years. The purpose of the study was to determine the minimal mean heart rate (HR-min) and longest pauses in heart rhythm, and to examine possible changes in these parameters over a longer period of time. (HR-min was calculated from a 1-min sample period.) HR-min was influenced by physical activity level and smoking habit, but was independent of age. Females had higher HR-min than males. In the male group mean HR-min was 54 beats min-1 and 53 beats min-1 on the two recordings (P greater than 0.05) (range 36-75 beats min-1 and 38-69 beats min-1). HR-min less than 40 beats min-1 was seen in 2.5% of the males. In the female group, the lowest recorded HR was 42 beats min-1 and mean HR-min on the two recordings was 58 beats min-1 and 56 beats min-1 (P less than 0.001). The paired HR-min observations were highly correlated. In all subjects, pauses greater than or equal to 1.75 s were registered in 6% and 6.5% on the two recordings. The occurrence of pauses was related to low HR-min. Above the age of 60 years sinus arrest was the type of pause most often seen.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

DNA ploidy and S-phase fraction in primary breast carcinomas in relation to prognostic factors and survival for premenopausal patients at high risk for recurrent disease.

Fine needle aspiration on small tumour pieces from 153 premenopausal women with primary breast cancer at high risk for developing recurrent disease has been used for flow cytometric DNA analysis; 133 of the tumours had either one or more cell populations different from diploid or a single, diploid cell population with an aspiration cytology showing presence of typical tumour cells. The distribution of tumour cell populations in this material was rather unusual with a high number of tetraploid populations. There were significant differences between various DNA ploidy classes with respect to prognostic factors such as lymph node involvement and oestrogen and progesterone receptor status. The S-phase fraction was significantly lower for diploid tumour cell populations compared to aneuploid populations. Diploid tumours with high S-phase fraction were not correlated to prognostic factors usually indicating a poor prognosis. Patients with an aneuploid tumour cell population classified as medium aneuploid had a significantly shorter recurrence-free survival than the rest of the patients. No conclusion on the effect of adjuvant treatment for patients with different tumour cell populations can be made at present.

Breast Neoplasms↗
PubMed1987

24-hour antiarrhythmic effect of conventional and slow-release verapamil in chronic atrial fibrillation.

Twenty-four-hour heart rate control by verapamil given as conventional tablets t.d.s., or as a new slow release formulation once daily, has been compared in an open cross-over trial. Eight patients with chronic atrial fibrillation and one with chronic atrial flutter were studied outside hospital. Trough serum concentration of verapamil did not differ during the two dosage regimens (59 ng/ml - conventional formulation and 49.3 ng/ml - slow release tablet). The average serum concentration of digoxin in the patients was not changed. Compared to the control phase, both dosage regimens significantly and equally reduced individual and average heart rates throughout the entire 24-h period. A positive correlation between the serum concentration of verapamil and the relative increase in average R-R interval was demonstrated. It is concluded that dosage t.d.s. with conventional tablets of verapamil or once daily with the slow release formulation gave the same antiarrhythmic efficacy over 24 h, and was associated with equal trough serum concentrations of verapamil.

Adult↗
PubMed1980

A dichtomy of the membrane potential response of rat soleus muscle fibers to low extracellular potassium concentrations.

The effects of different extracellular potassium concentrations [K+]o on the resting membrane potential (EM) of rat soleus muscle fibres was assessed in the absence and presence of 10(-3) M ouabain. At concentrations of 3 mM K and below, the fibres could be divided into two significantly different and normally distributed populations on the basis of EM response: One group responded to a lowering of the [K]o with a graded hyperpolarization to between -80 and -103 mM. The second fibre population had a less negative EM (-70 mV) which did not respond to changes in [K]o between 0 mM and 3 mM. In the [K]o range, 0 mM to 5.9 mM, the mean EM of fibres treated with ouabain was only slightly less negative than the EM of the second fibre population. We conclude that this dichtomy of the mean EM at low [K]o reflects the presence of two fibre types with different electrochemical properties.

Animals↗