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H Müsch

Publications and source records attributed to H Müsch.

2 recordsLinked to original sources

On loudness at threshold.

Absolute thresholds for and loudness matches between pure tones and four- and ten-tone complexes were used to assess the form of the function relating loudness to sensation level, SL, at low and moderate levels. The components of the tone complexes had equal SLs and were separated by one, two, four, or six critical bands. Six listeners with normal hearing were tested. The thresholds for the multitone complexes indicate that they generally can be detected even when the level of a single component is a few dB below the threshold. The average detection advantage is consistent with predictions for multiple observations in independent, frequency-selective auditory channels, but differences among listeners are apparent. The loudness matches also vary somewhat among listeners. Five of the six listeners matched tone complexes composed of subthreshold components to a pure tone a few dB above threshold. This indicates that the loudness of tones at or even below threshold is greater than zero for these five listeners. A simple model of loudness summation was used to obtain loudness functions from the individual listeners' loudness matches. The slopes of the loudness functions [log(loudness) plotted as a function of log(intensity)] generally exceed unity at low levels and are near 0.2 at 40 dB SL. This shallow slope at moderate levels agrees with loudness functions derived from data on temporal integration of loudness. The average loudness function derived from the present data also is in good agreement with a variety of previous data obtained by magnitude estimation, magnitude production, ratio production, and measurements of binaural loudness summation.

Adolescent↗

CA 125 in normal tissues and carcinomas of the uterine cervix, endometrium and fallopian tube. I. Immunohistochemical detection.

The distribution of cancer antigen 125 (CA 125) has been investigated in normal tissues and carcinomas of the Müllerian duct by immunohistochemical methods using the monoclonal antibody OC 125. Detection of CA 125 was most intense in cryostat sections and decreased in formalin fixed and paraffin embedded tissues according to the duration of fixation. Enzymatic digestion with neuraminidase or alkaline hydrolysis abolished specific staining suggesting the antigen is a sialylsaccharide bound to protein by alkali-labile linkage. Immunohistochemical staining demonstrated the presence of CA 125 in all normal glandular epithelia of the endocervix, endometrium and fallopian tube in different distribution patterns. In normal endometrium the cellular distribution pattern was related to the menstrual cycle. In endocervical, endometrial and tubal adenocarcinomas CA 125 was found in 73% of cases. In glandular structures the antigen was concentrated at the luminal surface of the tumour cells, in solid tumour areas it was spread throughout the cytoplasm or concentrated in large cytoplasmic vacuoles. The expression of CA 125 was considerably lower in solid tumour areas. These data show that CA 125 is not a true "tumour marker", but a product of female genital mucosae and of their cancerous derivates provided their synthesizing ability is not lost in the course of pathologic differentiation.

Antigens, Tumor-Associated, Carbohydrate↗