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Biomedical subjects

H MacDonald

Publications and source records attributed to H MacDonald.

31 records · Page 2Linked to original sources
PubMed1978

Phenobarbital and diphenylhydantoin levels in neonates with seizures.

Little information is available regarding appropriate plasma levels of anticonvulsant drugs in neonates. We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures. Following intravenous administration of 15 to 20 mg/kg, levels of 20.7 +/- 4.4 microgram/ml were achieved for phenobarbital and levels of 14.5 +/- 3 microgram/ml for DPH. Maintenance doses of 5 mg/kg of phenobarbital resulted in initial drug accumulation followed by more rapid elimination of the drug with increasing duration of exposure. Therapeutic plasma levels of DPH could not be achieved by oral administration in the neonate.

Administration, Oral↗
PubMedDate not supplied

Choice vegetables simultaneously for beta carotene. Vitamin C and fibre.

Beta-carotene, vitamin C, and fibre are found mainly in produce, that is, vegetables, fruits and grains. Unfortunately, grains, which have high content of fibre, are not normally consumed whole, and the most fibrous part might actually miss the alimentary tract. Fruits, which have high content of Vitamin C and are usually consumed unrefined, are expensive when not in season. In this article, we examine the possibility of maintaining recommended levels simultaneously of the nutrients mentioned with a short list of more popular vegetables, namely, broccoli, carrot, peas, sweet potato, and spinach.

Ascorbic Acid↗
PubMedDate not supplied

Alveolar soft-part sarcoma of the orbit.

Alveolar soft-part sarcoma is a malignant soft tissue neoplasm that involves mainly the deep soft tissues of the extremities, particularly the thighs and the buttock. Involvement of the orbit is uncommon. We describe a young child with such a tumor and illustrate the characteristic features.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Chronic renal disease: the mother's experience.

In a qualitative study, mothers (N = 4) of children with chronic renal disease were asked to share the meaning they assigned to their child's illness. The central theme of "uncertainty" emerged from the data and was described in three phases: (a) finding out, (b) learning to live with chronic illness, and (c) worries and dreams about the future. In this article phase three, labeled "learning to live with chronic illness," is presented.

Adaptation, Psychological↗
PubMedDate not supplied

"Mastering uncertainty:" mothering the child with asthma.

PURPOSE: To describe the meaning childhood asthma has for mothers of afflicted children. METHOD: The qualitative method, ethnography, was used in this study. Participant observation and indepth interviewing took place in the homes of the participants. Using a method adapted from Spradley (1979), the analysis included uncovering domains, taxonomies, components of meaning, and finally cultural themes. FINDINGS: The overall theme that emerged was "mastering uncertainty." The mothers expressed their experiences in terms of self by describing "internal self" and "actions" during a "passage of time." CONCLUSIONS: These themes can assist nurses and other health care professionals in understanding the meaning of childhood asthma to mothers.

Adaptation, Psychological↗