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Biomedical subjects

H Maes

Publications and source records attributed to H Maes.

At least 19 recordsLinked to original sources
PubMed1995

The speed tuning of medial superior temporal (MST) cell responses to optic-flow components.

The responses of macaque medial superior temporal (MST) cells to translation and to the optic-flow components-rotation, expansion/contraction, and deformation-were examined with particular regard to the speed tuning of MST cells for optic-flow stimuli and the effect of removing speed gradients from those stimuli. The use of position invariance as an indispensable criterion for assessing the authenticity of responses to optic flow is reviewed. By extending the scope of testing to include higher speeds it is found, in contrast to in previous reports, that MST cells generally respond to optic-flow components with a speed-response profile which is tuned for a particular range of speeds. Removal of the speed gradient had little effect on this observation. These and other properties of MST cells lead to the conclusion that one of the major functions of MST is the detection and encoding of self-motion.

Animals↗
PubMed1995

Alteration of the immune response during cancer development and prevention by administration of a mycobacterial antigen.

It has been shown previously that A60, an antigen complex of Mycobacterium bovis BCG, triggers humoral and cellular immune reactions in vivo and lymphocyte-dependent macrophage activation in vitro. In the present work, the ability of A60 to prevent murine tumour development, in conjunction or not with irradiated isologous cancer cells, was explored with Taper liver tumour (TLT), a mammary-derived neoplasm (EMT6), and Lewis lung carcinoma (3LL). Repeated injections of A60 prior to challenge reduced the incidence of EMT6 and 3LL solid tumours and increased life span. This effect was enhanced by simultaneous administration of gamma-irradiated cancer cells (80-100% suppression of EMT6 and 3LL tumour growth). In mice developing or rejecting tumours, the status of humoral and cellular immunity was evaluated by A60-based immunoassays. Tumor development was accompanied by a rapid decrease of both anti-A60 IgG titre in blood and A60-triggered delayed hypersensitivity reactions. Moreover, A60-induced T lymphocyte proliferation and macrophage-dependent autologous cancer cell cytolysis declined progressively during the course of tumour growth. In case of successful immunotherapy, a pattern similar to that of unchallenged controls was observed. Our results suggest that A60 promotes cancer rejection via tumour infiltration by lymphocytes and macrophages activated by A60-specific T lymphocytes. An increased processing of tumour-specific antigens and activation of tumour-infiltrating lymphocytes is induced by administration of irradiated cancer cells in conjunction with A60.

Adjuvants, Immunologic↗
PubMed1995

Processing of kinetically defined boundaries in the cortical motion area MT of the macaque monkey.

1. Electrophysiological recordings of 68 cells in the middle temporal area MT were made in paralyzed and anesthetized macaque monkeys. 2. Testing with our kinetic boundary stimuli always occurred under optimized conditions. To this end, the preferred direction, speed, stimulus position, and stimulus size of each cell were determined by quantitative tests. 3. The orientation selectivity to stationary luminance contrast edges served as a reference by which a response to kinetic boundaries could be compared. We found cells in area MT to be less selective to the orientation of luminance contrast stimuli than to the direction of motion. We confirmed the presence of neurons with preferred orientation aligned with their preferred direction. 4. The responses to kinetic edges defined by motion vectors moving in opposite directions, kinetic gratings with motion vectors in opposite directions, kinetic edges containing coherent motion and a stationary complementary field or coherent motion and a complementary field containing visual dynamic noise were compared. Kinetic boundaries were generated so that the motion vectors moved either parallel or orthogonal to the orientation of the discontinuity. For a cell to be considered as responding to the orientation of a kinetic boundary, it had to exhibit the same preferred orientation when the local motion vectors changed from parallel to orthogonal to the orientation of the kinetic boundary. 5. All cells in area MT changed their preferred orientation by 90 degrees when the coherent motion vectors changed from moving parallel to moving orthogonal to the boundary. This was the case independent of the types of kinetic boundary tested. We concluded that cells in area MT appear to respond to the motion vector over their classical receptive field (CRF) only and were unable to code the orientation of the kinetic boundary. 6. In those cells exhibiting an antagonistic surround, we examined the ability of the cell to code the position of a kinetic boundary. None of the cells tested signaled the position of a kinetic boundary. The side preference of the stimulus of the cells changed from left to right as the motion vectors in the stimulus reversed. This indicates that the cells were only selective for the motion vectors present over their CRF. 7. We found that the directional sensitivity of cells in area MT remained unaltered by the presence of additional motion vectors within the CRF. This suggests that cells in area MT extract a specific motion vector from a spatial configuration of vectors.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1994

Contrast modulated steady-state visual evoked potentials (CMSS VEPs): recording evoked potentials and related single cell responses in area 17 of the cat.

(1) The functional characteristics of the neuronal substrate, responding to the CMSS VEP stimulus, were studied by recording CMSS VEPs and related single unit activity in area 17 of the anaesthetised and paralysed cat. CMSS VEPs use an 8 Hz phase reversing (i.e., 16 reversals/sec) grating stimulus with rapid contrast sweeping and allow the contrast thresholds and lag values to be measured as a function of the spatial frequency. (2) The CMSS VEPs of the anaesthetised cat have a wave form similar to those of humans but are shifted to lower spatial frequencies, higher contrast thresholds and longer lag values. (3) The cellular response to a sinusoidal grating, phase reversing at 8 Hz, was studied in order to identify the neuronal substrate generating the CMSS VEPs. Sixty percent of the area 17 cells respond to this stimulus. Cells responding at 8 Hz reversal comprise a distinct subpopulation of visual cortical cells selective for higher velocities and lower spatial frequencies. (4) Although the CMSS VEPs contain almost exclusively energy at 16 Hz, the temporal response pattern of striate cells is quite disparate, including first and second harmonic response patterns as well as an intermediate type. (5) There is a near-perfect correlation between the contrast thresholds of single cells, obtained with the contrast swept stimulus and those obtained with a static contrast test, validating the technique of rapid linear contrast sweeping. (6) The influence of the temporal parameters of the contrast sweeping on the calculated contrast threshold was investigated at the neuronal level. These parameters only marginally influence the responses. (7) CMSS VEP contrast thresholds and neuronal thresholds were compared. The sensitivity of VEPs corresponds to that of the most sensitive neuronal generators. CMSS VEP lag values are longer than the values for individual neurones.

Animals↗
PubMed1994

Cardiovascular reactivity in isometric exercise and mental arithmetic in children.

In children, we studied noninvasively the cardiovascular stress responses, including changes over time of systolic blood pressure (SBP), heart rate (HR), and stroke volume (SV) in isometric handgrip (IHG) and mental arithmetic. Specifically, we asked whether 1) these cardiovascular stress responses were different for the two stress conditions in children, 2) these responses differed in boys and girls, and 3) the anthropometric variables related to these stress responses. SV differed significantly between IHG and mental arithmetic over the entire stress period. This may reflect higher systemic vascular resistance during IHG. HR in boys was lower than in girls over the entire period of stress in both stress tests. This observation cannot be attributed to differences in conditioning, because this should not influence responses to isometric or mental stress. A larger left ventricular mass was related to higher SVs. A marked relationship was found between HR and SBP and between HR and SV. No relationship was found between SBP and SV.

Blood Pressure↗
PubMed1994

Responses of macaque STS neurons to optic flow components: a comparison of areas MT and MST.

1. We recorded and tested quantitatively 65 middle temporal (MT) and 82 middle superior temporal (MST) cells in paralyzed and anesthetized monkeys. 2. Responses to the three elementary optic flow components (EFCs)--rotation, deformation, and expansion/contraction--and to translation (in the display) were compared after optimization of stimulus direction, speed, size, and position. As a control responses to flicker were measured. 3. Response windows were adapted in correspondence with our finding that latencies of MT and MST cells decrease with increasing speed for all types of motion. 4. There was a response continuum in MT as well as in MST cells. Compared with translation, MST cells responded significantly more to rotation but less to flicker than MT cells. MST cells were significantly more direction selective for expansion/contraction than MT cells. 5. MST cells generally responded to fewer motion types than MT cells. 6. Position invariance of EFC direction selectivity was tested over a region of the visual field centered on the translation receptive field (RF). Direction selectivity for an EFC was not position invariant in MT cells but it was invariant in 40% of the MST cells tested. These cells were considered EFC selective. 7. Most EFC-selective MST cells were selective for a single EFC, possibly combined with translation. Few of them were selective for deformation. 8. EFC selectivity was also speed invariant and EFC-selective MST cells usually had RFs summating inputs over wide portions of the visual field. 9. EFC-selective MST cells with similar selectivities were clustered.

Acceleration↗
PubMed1994

Size, fatness and relative fat distribution of males of contrasting maturity status during adolescence and as adults.

The somatic characteristics of boys of contrasting biological maturity status during adolescence are compared from 13-18 years and at 30 years of age. Within the mixed longitudinal Leuven Growth Study of Belgian Boys, 173 boys were followed annually from 13-18 years and were subsequently measured at 30 years of age. Age at peak height velocity (PHV) was estimated for 149 boys and the sample was then divided into three contrasting maturity categories based on the age at PHV: early (PHV < 13.37 years), average (PHV between 13.85 and 14.80 years) and late (PHV > 15.27 years) maturers. Using ANOVA for repeated measures and one-way ANOVA, differences in 18 somatic dimensions and five ratios of body proportions and subcutaneous fat distribution among the three maturity groups were tested from 13-18 years and at 30 years of age. There are consistent differences among boys of contrasting breadths, circumferences,and skinfolds on the trunk. There are no differences in skinfolds on the extremities. None of the differences in somatic dimensions and ratios among the three contrasting maturity groups are significant at 30 years of age except those for subscapular skinfold and the trunk/extremity skinfold ratio. Thus, during adolescence and in adulthood, late maturing boys have a distribution of subcutaneous fat that is associated with lower risk for several adult degenerative diseases.

Adipose Tissue↗
PubMed1993

Iatrogenic multiple pregnancies in East Flanders, Belgium.

OBJECTIVE: To evaluate the specific contribution of artificial induction of ovulation to the increasing number of multiple gestations in East Flanders and the effects of this treatment on the frequencies of monozygotic and dizygotic twinning. DESIGN: Since 1976 the East Flanders Prospective Twin Study has collected data on artificial induction of ovulation for all the multiple births listed in its registry. SETTING: East Flanders Prospective Twin Survey. PATIENTS: Between 1976 and 1992, 458 twin and 78 triplet pregnancies resulting from artificial induction of ovulation were analyzed. MAIN OUTCOME MEASURES: Zygosity and frequency of iatrogenic multiple births. RESULTS: Since 1985 there is an explosive increase in twin and triplet births in East Flanders. This increase has been caused mainly by the sole use of fertility-enhancing drugs and in the last few years by resorting to other technologies of assisted reproduction, such as IVF-ET, GIFT, or zygote intrafallopian transfer. CONCLUSION: In view of the elevated risk inherent to multiple pregnancies in terms of perinatal mortality and morbidity, the over enthusiastic or improper use of fertility drugs should be curtailed.

Belgium↗
PubMed1992

First-order analysis of optical flow in monkey brain.

Optical flow is a rich source of information about the three-dimensional motion and structure of the visual environment. Little is known of how the brain derives this information. One possibility is that it analyzes first-order elementary components of optical flow, such as expansion, rotation, and shear. Using a combination of physiological recordings and modeling techniques, we investigated the contribution of the middle superior temporal area (MST), a third-order cortical area in the dorsal visual pathway that receives inputs from the medial temporal area (MT). The results show (i) that MST cells, but not MT cells, are selective for elementary flow components (EFCs) alone or their combination with translation, (ii) that MST cells selective for an EFC do not extract this component from a more complex motion pattern, and (iii) that position invariance as observed in MST is compatible with an input arrangement from MT cells matching the selectivity of MST neurons.

Animals↗
PubMed1992

Age-specific correlation analysis of longitudinal physical fitness levels in men.

This study investigated the age-specific tracking of adult health- and performance-related fitness scores. In addition, the independent contribution of adolescent physical characteristics to the explanation of adult fitness scores was also studied. The sample consisted of 173 adults observed at age 30 years. These subjects had been followed at annual intervals from age 13 to age 18 years and were remeasured at age 30 years. At each age nine fitness tests were administered together with the recording of anthropometric dimensions, biological maturation, sports participation and family characteristics. Tracking was measured by the inter-age correlations at each age between 13 and 18 years and the performance scores at 30 years. The independent contribution of characteristics observed during adolescence to the explanation of adult fitness was investigated through stepwise multiple regression analysis and discriminant analysis with the adult fitness scores as the dependent variables and the fitness, maturation, anthropometric characteristics, sports participation and family background as the independent variables. Tracking between age 13 and age 30 years was moderately high (46% of variance explained) for flexibility, low to moderate (between 19% and 27% of variance explained) for the other fitness parameters and low for pulse recovery and static strength (7% to 11% of variance explained). Between age 18 and age 30 years the tracking was high for flexibility, moderately high for explosive and static strength, and moderate for the other fitness parameters except for pulse recovery. The amount of variance of adult fitness levels explained increased significantly when other characteristics observed during adolescence entered the regressions or discriminant functions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1992

Growth and menarcheal status of elite female gymnasts.

The growth and maturity status of 201 elite female gymnasts was considered. The subjects were participants at the 24 World Championship Artistic Gymnastics in 1987. In addition to age at menarche, weight, stature, biacromial, and bicristal breadths, the sitting height/stature ratio, and the Health-Carter anthropometric somatotype of gymnasts 13-20 yr of age were compared with reference data for a nationally representative sample of Flemish girls. Median age at menarche (probit analysis) in gymnasts is 15.6 +/- 2.1 yr compared with 13.2 +/- 1.2 yr in Flemish girls. Anthropometric dimensions increase with age until about 16 yr and then tend to plateau. In contrast to body size, there is little variation in somatotype with age. Compared with adolescent girls, elite gymnasts are considerably shorter and lighter with narrower shoulders and hips, but the differences are more apparent after 17 yr. Elite gymnasts do not differ from nonathletes in relative leg length, but they have proportionally broader shoulders relative to hips. Differences in somatotype occur primarily in endomorphy (especially lower in gymnasts) and to a lesser extent in mesomorphy (higher in gymnasts).

Adolescent↗
PubMed1991

Temporal integration in cat visual cortex: a test of Bloch's law.

Some units in the cat visual cortex fail to respond to a briefly flashed bar and it has been suggested that such neurons function as visual integrators with a long time constant. To test this integrator hypothesis, a study was made using presentations of a bar, flashed over the receptive field for various durations and at different luminances. Some cortical cells indeed showed an increase in the time to peak latency and in the response amplitude when stimulus duration was prolonged up to 320 msec. Such units obeyed Bloch's law for durations over 100 msec.

Animals↗
PubMed1991

Anthropometric characteristics of outstanding male and female gymnasts.

Anthropometric data of outstanding gymnasts were gathered on the occasion of the 24th World Championship Artistic Gymnastics, held at Rotterdam, The Netherlands, in October 1987. In total 165 males and 201 females were investigated, constituting 84% of the total number of participants. The data of these gymnasts were descriptively compared with both reference data and data reported in previous studies on gymnasts competing at international events. Also, based on the data obtained, 'gymnastic-specific' anthropometric reference values (i.e. profile charts), were established for both male and female gymnasts. Finally, the maturational characteristics (skeletal age and menarche) of the 'Rotterdam' female gymnasts were described.

Adolescent↗
PubMed1990

Selectivity of cat area 18 neurons for direction and speed in depth.

1. Fifty-eight area 18 cells recorded in anesthetized and paralyzed cats were tested for selectivity for direction in depth after their monocular velocity characteristics and static disparity profile were determined. 2. Direction in depth was produced by changing the speed and direction in the two eyes, but keeping the speed along axes in depth constant. 3. Forty-two cells were completely investigated, which means that direction in depth selectivity was tested at least at two different position disparities and two different bar speeds. Seven out of the 42 cells were accepted as direction in depth selective. 4. The 16 remaining cells were incompletely tested. Only one of them was direction in depth selective at the disparity and speed tested and shared all the properties of the seven completely tested direction in depth selective cells. Therefore we estimated that 8/58, i.e., 14% of the area 18 cells are direction in depth selective. 5. The direction in depth selective cells are a very homogeneous class: they all belong to the S family, are velocity tuned, monocular, prefer orientations close to vertical, and have a broad inhibitory or an unmodulated position disparity profile. 6. Direction in depth selectivity arises both from monocular properties and binocular interactions. These binocular interaction profiles can be symmetric or asymmetric. The change of these interaction profiles with changes in base speed can be summarized as changes in level of inhibition for the axes corresponding to equal speed in the two eyes on one hand and changes in the slope of the inhibition gradient centered on these axes of equal speed on the other hand. 7. Nineteen of the 58 cells were tested for selectivity for speed along trajectories in depth. All five direction in depth selective cells tested were also tuned to speed in depth. This suggests that area 18 contributes to the elaboration of a 3D velocity map. 8. A wiring diagram that accounts for the binocular interactions underlying direction selectivity in depth is presented.

Animals↗
PubMed1989

Genetic and environmental variation in the birth weight of twins.

Two novel approaches to the analysis of twin data are illustrated with data from birth weight in twins. First, two possible covariates of birth weight are fitted to the data simultaneously, allowing for linear effects of these variables, and their correlation. Second, information on chorionicity is used to estimate the effects of chorion type on birth weight. The data were collected from a large sample of twins born in East Flanders, Belgium. Variation and covariation in twins were considered as a function of sex, chorionicity, maternal age, gestational age, and genotype. No evidence for sex differences in causes of variation was found. As expected, the largest source of variation in bith weight was associated with gestational age. Other common environmental influences were non-significant. Heritability was significant, constituting approximately 40% of variation not associated with maternal and gestational age. A small but significant effect of chorionicity was found, such that dichorionic twins show a greater similarity than monochorionic.

Birth Weight↗
PubMed1987

The velocity dependence of direction selectivity of visual cortical neurones in the cat.

1. The range of velocities, yielding direction-selective responses, was investigated in a total of 167 direction-selective cells from areas 17 and 18 of the cat, using a high-contrast light bar moving at velocities ranging from 0.6 to 900 deg s-1. 2. 11% of the cells were direction selective over the full range of velocities tested. Most cells (66%) gave only responses at low velocities and thus were not direction selective at high velocities. The remaining cells gave responses over a broad range of velocities but the direction selectivity was limited to either high or intermediate velocities (18 and 5% of the cells, respectively). Cells with direction selectivity at high but not at low velocities had large receptive fields with non-overlapping 'on' and 'off' subregions and they responded quickly and phasically to stationary flashes. This suggests that the latter cells relied on fast and brief interactions over large distances. 3. In thirty cells the spatial and temporal limits of direction selectivity were investigated using a stroboscopically illuminated moving light bar. In all cells direction selectivity depended both on the interflash distance and the interflash time interval. Area 17 cells with large receptive field at high eccentricity tolerated much larger interflash spacings than area 17 cells with small receptive fields near the area centralis. For eleven of the thirty cells the effective interflash distance could be larger than the width of the receptive field. The largest effective interflash time interval varied between 35 and 250 ms. 4. Eight of the thirty cells were direction selective at high but not at low velocities. These eight cells all remained direction selective over large interflash distances and they required brief interflash intervals (less than or equal to 65 ms). 5. Responses to single stroboscopic flashes within the sequence were observed in ten cells, which all responded well at high apparent velocities. While most cells (eight out of ten) showed both response increments in the preferred direction and response decrements in the non-preferred, the decrements constituted the dominant element in the direction selectivity of six out of ten cells while the remaining four cells relied mainly on response increments. 6. It is concluded that the range of direction-selective velocities of some cat visual cortical cells can be predicted from a knowledge of the spatial extent and the time course of the direction-selective interactions.(ABSTRACT TRUNCATED AT 400 WORDS)

Action Potentials↗
PubMed1987

The suppressive influence of moving textured backgrounds on responses of cat striate neurons to moving bars.

The suppressive action of a moving textured background on responses to moving bars was investigated in 118 striate neurons, 19 dorsal lateral geniculate neurons, and 5 perigeniculate neurons in paralyzed and anesthetized cats. In standard conditions the background was a two-dimensional (2D) noise pattern, the bar moved at optimal speed, and its contrast level was adjusted to yield 50% of the maximum response. Neuronal responses to the moving bar were suppressed when the background moved at the same speed or faster than the bar. The direction of motion of the bar had little influence. This suppressive effect was equally strong in all three experimental samples. The suppressive effect of the moving background was uniformly distributed among the cortical population, being equally strong in all layers, in all parts of the visual field representation, and for different categories of cortical cells. The suppressive effect of the moving background depended little on the structure of the background or on the speed of the bar. The suppression increased with decreasing contrast of the bar. Many (80%) cortical cells and all geniculate neurons responded to the movement of the 2D noise on its own. Most of these cells responded to isolated features ("grains") in the pattern rather than to movement of the whole pattern. There was no difference in strength of suppression between cortical neurons responsive and unresponsive to the moving 2D noise. The possible origins of this suppressive influence of moving backgrounds and its significance for the processing of visual scenes, more complicated than a single stimulus, are discussed.

Animals↗