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Biomedical subjects

H Manabe

Publications and source records attributed to H Manabe.

At least 127 records · Page 7Linked to original sources
PubMed1983

Ultrastructure of the congenital epulis.

This report presents the ultrastructural features of a congenital epulis. The granular cells of the epulis were packed with numerous membrane bound cytoplasmic granules containing particles, small vesicles, and electron-dense materials. These granules were negative in immunohistochemical reaction for CEA (DAKO PAP KIT). Cytoplasmic organelles such as mitochondria, rough surfaced endoplasmic reticulum, and Golgi apparatus, were absent. Nuclei were markedly indented. Occasionally, banded intracellular collagen fibrils were observed within the cytoplasm. Some of these fibrils were surrounded by a limiting membrane, whereas others appeared to lie free in the cytoplasm. The collagen fibrils were also seen within a deep invagination of the cell surface. There was no basal lamina around the granular cells. Sporadically, mast cells with many granules containing lamellar formations were found between the granular cells. These observations support the idea that granular cells of the congenital epulis are derived from mesenchymal cells, probably fibroblasts.

Basement Membrane↗
PubMed1983

Surgical treatment for severe congenital heart diseases.

The surgical results in patients with severe congenital heart disease, who underwent surgical treatment between 1978 and 1981 at the National Cardiovascular Center, Japan, were analyzed. The surgical mortality rates were 4% for cases of ventricular septal defect associated with pulmonary hypertension in patients under 2 years of age, 16.7% for complete atrio-ventricular canal, 11% for coarctation of the aorta associated with ventricular septal defect, 40% for pure pulmonary atresia without Ebstein anomaly, 44% for total anomalous pulmonary venous return, 14.8% for transposition of the great arteries, 44% for double outlet right ventricle and 1.1% for tetralogy of Fallot. The surgical results have been improving and postoperative residua and sequelae have been decreasing through our persistent efforts. Today's main problem is a relatively poor performance in cases which need surgical intervention early in life, i.e., under 3 months of age. Therefore, we think that our effort to improve the surgical results for new-borns or very young infants is most necessary.

Aortic Coarctation↗
PubMed1983

Myocarditis in children--Clinical findings and myocardial biopsy findings.

Eight children with myocarditis underwent a cardiac catheterization study and right ventricular endomyocardial biopsy. The degree of histological changes of the biopsy specimens correlated well with the severity of the clinical manifestations. Patients who had evidence of residual functional impairment had biopsy findings compatible with their clinical course.

Adolescent↗
PubMed1983

[Giant left atrium in mitral valve disease: a new plication procedure to relieve the compressions of left ventricular wall left bronchus and right lung].

The giant left atrium associated with mitral valve disease frequently produces postoperative hazardness in relation to hemodynamic and respiratory management. We have defined the most serious disorders induced by the presence of giant left atrium in three categories as follows. First, hemodynamic disturbance by the compression of left ventricular wall by downward extension of left atrium (type I), secondly, respiratory disturbance yielded by the compression of left main bronchus by upward extension of left atrium (type II), thirdly, compression of right middle lobe by rightward extension of left atrium (type III). A new procedure of para-annular, superior and right-side plication methods were derived as the procedure to relieve those compressions induced by giant left atrium. Up to the present, 47 patients with giant left atrium underwent surgery, twelve of valvular procedure only and thirty-five of valvular as well as plication procedure. The incidence of postoperative low output syndrome and respiratory failure were evaluated. The plication procedure showed marked decrease in the incidence of low output syndrome and respiratory failure postoperatively, eventual significant decrease in mortality rate. We conclude that plication procedure is very effective for the treatment of compression in the presence of giant left. atrium.

Cardiac Output, Low↗
PubMed1983

Antibody specific for lung cancer cells detected in sera of patients with bronchogenic carcinoma.

Two hundred and seventy-one sera from patients with lung cancer were checked to determine whether they exerted a blocking or potentiating effect on normal lymphocyte-cytotoxicity against lung cancer targets using a microcytotoxicity assay. A blocking effect was observed in 15 of 49 untreated patients (30.6%), but a potentiating effect was detected in 10 of 49 (20.4%). Such effects were not correlated with stages of the disease or the clinical status of patients. Such a blocking effect was also detected in patients with pneumonia, pulmonary tuberculosis, benign mediastinal tumor and malignancies other than lung cancer, but the potentiating effect could not detected in such patients. Using an indirect membrane immunofluorescence test, IgG antibodies against QG-56 of a lung cancer cell line were detected in 54.3% of potentiating sera and in 20.5% of blocking sera. Such antibodies were cross-reactive with 2 other lung cancer cell lines and one of 4 uterine cancer lines, however, no cross-reaction was observed against 3 breast cancer lines, 3 of 4 uterine cancer lines, one malignant melanoma line and one pancreas cancer line. The effector cells exerting the potentiating effect were identified as non-adherent, Fc receptor-bearing lymphocytes. Therefore, the potentiating effect might be typical antibody-dependent cell-mediated cytotoxicity.

Antibodies, Neoplasm↗
PubMed1983

[Heart valve replacement with the Ionescu-Shiley bovine pericardial xenograft. Hemodynamic evaluation and early clinical follow-up of 170 patients].

The Ionescu-Shiley bovine pericardial xenograft (ISPX) has been widely accepted clinically because of its superior hemodynamic characteristics and low incidence of thrombogenicity. After confirmation by our own experiment of its superior valve performance, we have adopted in clinical application of this valve since August of 1979, and implanted 189 of this valve in 170 patients up to November of 1981. The overall mortality rate including of hospital and follow up death was 14.1%. The pressure gradient and calculated orifice area of ISPX were compared to those of Hancock xenograft (HX), and the valve characteristics of ISPXs was found to be better than those of HX. The cardiac function following implantation of this valve apparently showed improvement. No incidence of thromboembolic episode or malfunction was observed, however, prosthetic valve endocarditis (PVE) was encountered in four patients and two died. This incidence of PVE in ISPXs was not significantly higher in comparison to that in other type of prosthetic valve. However the low incidence of thromboembolic episode as well as acceptable valve performance were confirmed by our study, the durability and susceptibility to PVE has to be carefully observed in the longer follow up.

Aortic Valve↗