Biomedical subjects

H Mansour

Publications and source records attributed to H Mansour.

39 records · Page 3Linked to original sources

PubMed1986

[Transplantation of serotonin neurons in the olfactory bulb of the adult rat].

Serotonergic neurons have their perikaraya concentrated in the raphe nuclei. In the present experiment, pieces of raphe nuclei containing serotonergic neuroblasts were dissected from 14 days rat embryos, mechanically dissociated, and 1 microliter of a cell suspension containing 30,000 cells was injected slowly under stereotaxic control in the olfactory bulb of adult rats. Three weeks after transplantation, the brain of the rats were processed for immunocytochemical detection of 5-HT. In all of the grafted animals, 5-HT neurons were found in the olfactory bulb. They exhibited the morphology of adult neurons, with well developed axon and dendrites, extending far from the injection site. Ultrastructural immunocytochemistry disclosed afferent and efferent synapses to the grafted neurons. Three preliminary results indicates that the transplanted neurons have been integrated in the host's neuronal circuitry. Ongoing electrophysiological studies are now directed at investigating the functional status of these grafted neurons.

Animals↗

PubMed1985

[Is there currently a role for radical surgery of pain?].

Radical surgery of pain is destined for chronic and intolerable pain, resistant to causal treatment, and rebellious to the various medicinal therapeutics. Conventional neuro surgery by selective section of nociceptive fibers is very valuable for cancerous subjects with a limited life span. On the other hand, there has been skepticism concerning the real efficiency of neuro stimulation. The advance made in the knowledge of neurophysiologic and neurochemical mechanism of pain will allow a radical transformation as substitute for this invasive type surgery.

Central Nervous System↗

PubMed1983

Non-hypoxaemic pulmonary oedema induced by alpha-naphthyl thiourea in the rat.

The time course of the respiratory consequences of alpha-naphthyl thiourea (ANTU)-induced lung oedema was studied in adult albino rats, up to 6 h after the injection of 5 mg/kg ANTU. Control rats were injected with olive oil (ANTU solvent). After 6 h, pulmonary extravascular water increased by 50% in ANTU-treated rats and the volume of the pleural effusion reached 3.4 +/- 0.1 ml (mean +/- s.e. mean). The most striking point is the absence of hypoxaemia in the ANTU-treated rats: PaO2 = 103 +/- 1.5 Torr vs 100 +/- 1 Torr in the control rats. The non-decreased PaO2 can be related to the patency of the alveolar airspaces. The predominant location of the oedema in the lung interstitium is caused by a specific lymphatic drainage pathway towards the pleura in the rat which prevents alveolar flooding. Histological findings support this hypothesis. PaCO2 is unaltered: 32 +/- 1 Torr in ANTU rats vs 33.5 +/- 1 Torr in control rats. A slight downward shift of arterial pH is found in ANTU rats: (7.440 +/- 0.010 vs 7.475 +/- 0.010, P less than 0.01). Concomittently (HCO3-)a decreases in ANTU-treated rats (22.2 +/- 1.2 mmol l-1 vs 24.8 +/- 0.6 mmol l-1, P less than 0.01). The absence of hypoxaemia is common with normobaric oxygen (02) and ANTU-induced lung oedema in the rat. A comparison is made between 02 and ANTU toxicity, as for respiratory events and histological features.

Animals↗