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Biomedical subjects

H Mattern

Publications and source records attributed to H Mattern.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Echocardiographic diagnosis of malfunction of the Björk-Shiley prosthetic heart valve in the mitral position (author's transl)].

In patients with mitral valve replacement an acute cardiac decompensation most often signalizes malfunction of the prosthesis. Echocardiography proves to be of great value in the noninvasive diagnostic to detecting valve dysfunction. The echocardiogram of two patients few weeks after cardiac surgery was strongly suggestive of perivalve leak with severe regurgitation: enlarged left atrium and left ventricle, hyperactive septal motion and hyperkinetic motion of the left ventricular posterior wall, unique "hump" in early diastole with normal excursion, opening and closing velocity of the disc. The echocardiogram of one patient exhibited the pattern of mitral stenosis: large left atrium, decreased amplitude of excursion of the opening of the disc with a slowing and "rounded" opening upstroke as well as a slowed and "rounded" downstroke with prolonged opening and closing rates of the disc. One patient with aortic and mitral valve replacement showed no echocardiographic signs of abnormal disc motion. The reason for the cardiac decompensation was an acute malfunction of the left ventricle. The echocardiographic findings were confirmed by cardiac catheterization, left ventricular cineangiography or direct inspection during open heart surgery.

Adult↗
PubMed1979

[Exercise capacity and physical activity following prosthetic valve replacement in relation to cardiovascular function (author's transl)].

31 patients (Pt) with Mitral Valve Repacement (MVR), 22 Pt with Aortic VR (AVR) and 10 Pt with Double VR (DVR) are investigated hemodynamically and by ergometry. Normal working capacity (100% WC) has been achieved in 59% of Pt with AVR, in 34% with MVR and in 22% with DVR. Pulmonary artery mean pressure (PAMP) in this group was 19.5 mmHg, in a second group with a WC of 80% PAMP was 22.2 mmHG. 77% OF Pt with AVR are working regularly, in MVR 58% and in DVR 50%. In the average of these Pt, 7 months after VR professional occupation is started again. PAMP and pulmonary vascular resistance (APR) is significantly lower in the working vs. the non working group: PAMP 19.8/23.7 mmHg; APR 115/145 dynes sec cm-5, respectively. In MVR, the transprosthetic pressure gradient at rest was 4.1 (working PPT) and 7.5 mmHg (other); in AVR statistically no significant difference in the gradient could be found. In general, 68% of the working Pt are employed in a preferably sedentary job. The mean duration of daily work was estimated to 6.7 hours. It is concluded that AVR yields more favourable results in terms of regaining normal working activity than MVR. Cardiovascular function and physical capability in Pt with DVR are approximately comparable to MVR.

Adult↗
PubMed1976

[Pseudodystrophic muscle glycogenosis in adults. (Acid maltase deficiency syndrome) (author's transl)].

A 40-year-old man suffered for 5 years from a progressive proximal myopathy mimicking an atypical limb-girdle dystrophy. A "myopathic" pattern with myotonic and pseudomyotonic discharges was determined by electromyography. Enzyme histochemical and ultrastructural investigations of muscle and liver biopsies pointed to a glycogenosis. Biochemical investigations of muscle and liver samples confirmed this diagnosis, disclosing an acid maltase deficiency. Glycogen filled lysosomes were also revealed electron optically in skin fibroblasts but not in white blood cells. The literature concerning the late onset forms of acid maltase deficiency (type II glycogenosis) has been reviewed, and the clinical course has been compared with that of the infantile form (Pompe's disease). In early infancy the disease has a short and fatal course, with involvement of many organs. primarily skeletal muscules, liver and heart. In the late infantile and juvenile forms the course of the disease is slower, the organ involvement beeing not as severe; muscular symptoms begin to prevail. In adults, type II glycogenosis mimics muscular dystrophy with its prolonged course and the almost exclusive clinical involvement of proximal muscles. Biochemical and ultrastructural investigations have nevertheless demonstrated that other organs and tissues are also involved. The reasons for the variability of organ involvements in different ages are as yet unknown.

Adolescent↗