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Biomedical subjects

H Matthys

Publications and source records attributed to H Matthys.

At least 109 records · Page 6Linked to original sources
PubMed1987

Action of tulobuterol and fenoterol on the mucociliary clearance.

The influence of tulobuterol and fenoterol upon mucociliary clearance (mC) and airway obstruction was investigated in 8 patients with chronic obstructive bronchitis and two patients with chronic bronchial asthma. The lung function and mC measurements were repeated after a 1-week random oral treatment with 4 mg tulobuterol/day or 7.5 mg fenoterol/day in a double-blind cross-over design. Tulobuterol and fenoterol improved mC of the total, central and peripheral bronchial tree significantly in comparison to the pretreatment values (p less than 0.001) reaching, after beta 2-agonist therapy, values observed in normal subjects. In comparison to no treatment and pretreatment with oral fenoterol, tulobuterol protected slightly better from the inhalative provocation with 99mTc radioactive erythrocytes used to measure mC. Inhalative fenoterol was more efficient than oral fenoterol or tulobuterol to reverse the bronchospastic part of airway obstruction. No differences of mean daily peak flows, systolic and diastolic systemic blood pressure measurements and pulse rate were recorded during tulobuterol and fenoterol treatment. Both drugs were tolerated without side effects.

Adrenergic beta-Agonists↗
PubMed1987

Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis.

To study the local distribution of lymphocyte subsets in inorganic dust diseases, bronchoalveolar lavage (BAL) was performed in seven patients with asbestosis, and in 13 patients with mixed dust pneumoconiosis (anthracosidero-silicosis). Lymphocyte subsets in BAL and blood were determined by the monoclonal antibodies OKT3 (pan T), OKT4 (helper/inducer), OKT8 (suppressor/cytotoxic), B1 (B-cells), OKIa (HLA-DR antigens), and Leu-7 (natural killer). The BAL lymphocytes were moderately elevated to 15 +/- 8 percent (mean +/- SD) in mixed dust pneumoconiosis, and even more markedly increased to 28 +/- 21 percent in asbestosis. The OKT4/OKT8 ratio in BAL was significantly increased to 4.5 +/- 2.1 in asbestosis, and significantly reduced to 0.9 +/- 0.8 in mixed dust pneumoconiosis. In blood, the ratio of T-cell subsets remained unchanged, though total lymphocytes were decreased in asbestosis. These results suggest altered cellular immune processes in the lungs of patients with pneumoconiosis and may indicate different immunoregulatory changes depending on the nature of the inhaled dust.

Adolescent↗
PubMed1986

Predictive value of bronchoalveolar T cell subsets for the course of pulmonary sarcoidosis.

To study the value of knowing the proportions of bronchoalveolar T cell subsets when predicting the course of pulmonary sarcoidosis, we subjected 31 patients to clinical, physiologic, and radiographic evaluations, with controls, for at least 12 months. Initially, when all patients were untreated, BAL's were performed, and BAL lymphocyte subsets were marked by the following monoclonal antibodies: OKT3 (expressed by all T cells), OKT4 (to mark helper-inducer T cells), OKT8 (to mark suppressor-cytotoxic T cells), and OKIa (to mark Ia antigen-positive, activated T cells). A normal T4/T8 ratio was highly predictive of a favorable course: the conditions of 13 out of 15 patients with normal ratios remained stable or improved, and only 2 of these 15 patients had to be treated because of persistent symptoms. On the other hand, the conditions of 10 out of 16 patients with elevated T4/T8 ratios deteriorated during the follow-up period. The specificity of T cell subsets for predicting deterioration was improved by considering both the T4/T8 ratio and the number of Ia antigen-positive, activated T cells present. Deterioration occurred in 9 out of 11 patients with elevated T4/T8 ratios and elevated levels of activated T cells. These results suggest that the subtyping of BAL lymphocytes may be useful in determining prognosis in pulmonary sarcoidosis.

Adult↗
PubMed1986

HLA-DR antigens on human macrophages from bronchoalveolar lavage fluid.

The expression of HLA-DR (Ia-like) antigens on human macrophages was investigated by analyses of cells from bronchoalveolar lavage fluid obtained from 12 patients with pulmonary sarcoidosis, six patients with extrinsic allergic alveolitis, nine patients with cryptogenic fibrosing alveolitis, 11 normal non-smokers, and 12 normal smokers. The HLA-DR antigen was demonstrated by the mouse monoclonal antibody OKIa by a peroxidase-antiperoxidase method performed on glass slides. No differences were found in the percentage of alveolar macrophages that expressed DR antigens between the five study groups. OKIa positivity was observed on more than 90% of macrophages in all cases. These observations suggest that the previously reported enhanced antigen presentation by alveolar macrophages in sarcoidosis is not linked with an increase in the percentage of DR+ macrophages in the lung.

Adult↗
PubMed1986

Alterations in immunoregulatory T-cell subsets in cigarette smokers. A phenotypic analysis of bronchoalveolar and blood lymphocytes.

Abnormalities in the proportions of immunoregulatory T-lymphocytes in bronchoalveolar lavage fluid have been reported in interstitial pulmonary diseases, yet the effect of cigarette smoking on T-cell subsets in bronchoalveolar lavage fluid from normal subjects has not been investigated. We applied an immunoperoxidase technique performed on glass slides using the monoclonal antibodies, OKT3, OKT4, OKT8, OKIa, and Leu-7 to study T-cell subsets in bronchoalveolar lavage fluid and blood of 11 normal nonsmokers and 12 smokers. In the bronchoalveolar lavage fluid of smokers, a decrease in the percentage of OKT4+ helper/inducer and an increase in OKT8+ suppressor/cytotoxic cells resulted in a markedly decreased OKT4/OKT8 ratio (0.9 +/- 0.4) compared with nonsmokers (1.9 +/- 0.8) (p less than 0.005). These abnormalities of lymphocyte subsets in bronchoalveolar lavage fluid correlated with the cumulative pack-years of smoking history but were not reflected in the peripheral blood. These results suggest that cellular immunoregulation is disturbed in the lungs of cigarette smokers. This may play a role in pulmonary defense mechanisms and tumor immunity.

Adult↗
PubMed1986

Bronchosparing properties of celiprolol, a new beta 1, alpha 2-blocker, in propranolol-sensitive asthmatic patients.

The bronchopulmonary effects of celiprolol were studied in 12 male asthmatic patients who showed mean maximum changes of -24% in forced one-second expiratory volume (FEV1) and 130% in airways resistance (Raw) following a single, 80 mg dose of propranolol. Celiprolol 200 and 400 mg and placebo were administered in double-blind, random fashion. Raw and FEV1 were determined by whole body plethysmography 1, 2, and 3 h post dose. For placebo and celiprolol 200 and 400 mg, mean maximum changes in FEV1 were 0.6, 2.8, and 2.4%, and for Raw, 11.3, -0.2, and -10.9%, respectively. Pulmonary effects of the three treatments were indistinguishable but differed significantly from propranolol. Five 0.5 mg doses of terbutaline aerosol, administered at 15-min intervals starting 3 h post drug or placebo, caused less bronchodilation after propranolol than after placebo, or celiprolol 200 or 400 mg; the responses after the latter three were indistinguishable. These results suggest that celiprolol is highly bronchosparing and does not block bronchodilation following the beta 2-agonist terbutaline in propranolol-sensitive asthmatics. In contrast to classical beta-adrenoceptor antagonists, celiprolol may afford a greater margin of safety in asthmatic patients with angina or hypertension.

Adrenergic alpha-Antagonists↗
PubMed1986

Mucociliary clearance in smokers.

The mucociliary clearance characteristics and the correlation between the extent of smoking and bronchial mucociliary dysfunction were studied in 71 smokers (15 without chronic bronchitis, 16 with simple and 40 with obstructive chronic bronchitis). Mucociliary clearance (MC) was measured with 99mTc-tagged human erythrocytes. Lung function values were determined by whole body plethysmography. All three smoking groups had significantly (p less than 0.001) lower TMC60.min rates (total MC in 60 min) on the average than the predicted values. The mean TMC60.min rates of heavy smokers with simple and obstructive chronic bronchitis were significantly (p less than 0.001) lower than that of light smokers without chronic bronchitis. There was no significant difference between the TMC60.min rates of smokers with simple and obstructive chronic bronchitis. The decrease in the MC rates was more pronounced in the central than in the peripheral airways. A significant (p less than 0.001) correlation was found between the extent of smoking (pack years) and the decrease of MC. The results suggest that the decrease of MC is an early functional abnormality in smokers, which precedes the development of symptoms of chronic bronchitis as well as functional detectability of airways obstruction.

Bronchitis↗
PubMed1985

[Gold-induced fibrosing alveolitis].

Fibrotic alveolitis appeared in a 54-year-old patient undergoing gold therapy. In differential diagnosis, this infrequent side effect of gold therapy is to be distinguished from rheumatoid lung fibrosis. Lymphocyte sub-populations were determined in the broncho-alveolar lavage fluid of the patient. The results obtained support the view that the side effect is due to an immunologically mediated process.

Arthritis, Rheumatoid↗