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Biomedical subjects

H Mehta

Publications and source records attributed to H Mehta.

48 records · Page 3Linked to original sources
PubMed1981

Misdiagnosis of black patients with manic depressive illness: second in a series.

In a previous article (J Natl Med Assoc 72(2): 141, 1980), the authors proposed that, despite several attempts to lay to rest the myth that blacks do not demonstrate similar prevalence rates of manic depressive illness when compared to whites, many black patients with manic depressive illness are frequently misdiagnosed. In a survey of the outpatient psychiatric clinic at Jackson Park Hospital, it was found that black patients in this clinic have similar prevalence rates of manic depressive illness when compared to surveys of white patient populations. In addition, it was found that the demographic characteristics of this subgroup of manic depressive patients were very similar to those found in white manic depressive patients. Yet, when the past histories of these black manic depressive patients were reviewed, there were large numbers of patients who received a diagnosis of schizophrenia and, thus, were not considered for treatment with lithium.

Adult↗
PubMed1981

Pulmonary resection in cystic fibrosis: a case report.

There is limited experience world wide in the management of patients with cystic fibrosis who undergo thoracotomy. Because of their shortened life-span and the diffuse nature of pulmonary involvement, resection is seldom performed for uncontrolled pulmonary infections. An 8-year-old boy with cystic fibrosis and a chronic infection of the right lung with abscess formation underwent pulmonary resection after 1 week of antibiotic therapy with tobramycin, ticarcillin and cloxacillin, and physiotherapy. Postoperatively, he was kept in the intensive care unit for 48 hours. Physiotherapy was begun immediately after operation and continued every 2 hours for the first day. The preoperative antibiotic therapy was continued. The postoperative course was smooth and the boy did well for 1 year. Over the next 6 months his condition deteriorated and he died 18 months after operation. Pulmonary resection should not be used in patients whose pulmonary infections can be controlled medically but may be of value for those with uncontrollable localized infections.

Anti-Bacterial Agents↗
PubMed1980

Smallpox surveillance in Bangladesh: II - Smallpox facial scar survey assessment of surveillance effectiveness.

A smallpox facial scar survey of 465 892 persons aged 0-19 years was carried out in Bangladesh in 1976, covering approximately 1% of the 0-19 year old population. Of the 4 306 persons found with facial scarring consistent with previous smallpox infection, none had a history of smallpox with onset after the last reported case on October 16, 1975. Histories taken from persons with facial scars allowed smallpox incidence to be estimated for each year from 1972 to 1975. These estimates indicate that completeness of reporting increased steadily from 11.8% in 1972 to 83.0% in 1975, reflecting the increasing effectiveness of surveillance.

Adolescent↗
PubMed1980

The misdiagnosis of black patients with manic depressive illness.

It has been shown repeatedly that, contrary to earlier beliefs, blacks may well demonstrate similar prevalence rates for manic depressive illness when compared with whites. Yet the authors believe that black manic depressive patients are frequently misdiagnosed as being chronic undifferentiated schizophrenics and treated with major tranquilizers when lithium is the drug of choice. This contention is supported by three case histories and some institutional dynamics that cause this form of iatrogenic morbidity to continue to prey upon black psychiatric patients.

Adult↗
PubMed1979

Surgical management of carcinoma of eyelids and periorbital skin.

An appraisal of a personal series of 115 unselected and surgically treated cutaneous cancers of palpebral region is presented. Histological confirmation of the diagnosis and adequacy of excision was obtained for all lesions. Seven of the 8 patients with doubtful clearance were successfully treated with further surgery very soon. Complications were few, the incidence of reoperations low, and cosmetic as well as functional results were mostly satisfactory. Tumour recurred in 1 case (0.87%). Two patients had a poor cosmetic result. Seventy-nine cases (69%) were treated as day cases under local anaesthesia even for major repairs like full-thickness reconstruction of two-thirds of the lower eyelid and repairs with large full-thickness skin grafts of up to 20 x 55 mm by a new simple technique of graft fixation. The use of longer-acting local anaesthetics in oculoplastic surgery is described. Attention is drawn to the dangers of using direct wound closure for repair.

Adult↗
PubMed1976

Interaction of Vibrio cholerae toxin with sarcoma 180 cell membranes.

Three discrete phases are discernible in the activation, by Vibrio cholerae toxin, of adenylate cyclase in fragments of sarcoma 180 cell membranes. In the first, or preparatory, phase the toxin must be exposed to dithiothreitol or nicotinamide adenine dinucleotide (NAD) in the absence of the membranes. In the second phase, the prepared toxin is dissociated to yield a macromolecular cyclase-activating factor (MCAF) in the presence of the membranes. In the third phase, membrane basal adenylate cyclase is activated by MCAF in the presence of NAD. The integrity of the catecholamine or beta-receptor associated with sarcoma adenylate cyclase is irrelevant in the activation of cyclase by MCAF. This activation proceeds undiminished even if the beta-receptor is desensitized or blocked by propranolol.

Adenosine Triphosphate↗
PubMed1975

Cholera toxin activation of adenylate cyclase in cancer cell membrane fragments.

Activation of adenylate [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] by cholera toxin (84,000 daltons, 5.5 S) is demonstrated in plasma membrane fragments of mouse ascites cancer cells. The activation of adenylate cyclase is mediated by a macromolecular cyclase activating factor (MCAF), which has a sedimentation constant of 2.7 S and a molecular weight of about 26,000. MCAF is derived from, and may be identical to the "A fragment" of cholera toxin. Generation of MCAF depends on prior interaction of cholera toxin with either dithiothreitol, NADH, NAD, or a low-molecular-weight component (less than 700 daltons) present in cytoplasm. Subsequent exposure of this pretreated cholera toxin to cell membranes from a variety of mouse ascites cancer cells is followed rapidly by the appearance of MCAF, which no longer requires dithiothreitol, NADH, or NAD for the activation of adenylate cyclase. Activation of adenylate cyclase by MCAF in ascites cancer cell membrane fragments is not reversed by repeated washing of these membrane fragments. Adenylate cyclase in normal cell membrane fragments fails to respond either to cholera toxin or MCAF in the presence of dithiothreitol. In striking contrast, the adenylate cyclase in membrane fragments from five ascites cancer cells responds to either MCAF or native cholera toxin preincubated with dithiothreitol, NADH, or NAD.

Adenylyl Cyclases↗
PubMedDate not supplied

Complete agenesis of the right and left pulmonary arteries, with main pulmonary artery originating from the right ventricle, presenting as primary pulmonary hypertension of the newborn: case report.

A female infant who had been misdiagnosed as having primary pulmonary hypertension of the newborn was found to have agenesis of the branch pulmonary arteries with collateral-dependent pulmonary circulation. The intracardiac anatomy was completely normal. Unifocalization of branch pulmonary artery was done, followed by stenting of the ductus arteriosus.

Diagnosis, Differential↗