PubMed Health⌕ Search

Biomedical subjects

H Meier

Publications and source records attributed to H Meier.

At least 55 records · Page 3Linked to original sources
PubMed1987

Enzymatic determination of red cell creatine as an index of hemolysis.

An enzymatic assay for creatine, depending on the creatine kinase reaction, has been modified for the determination of creatine in packed erythrocytes, using a centrifugal analyzer (COBAS BIO). The method is precise, sensitive and shows excellent accuracy in recovery experiments when compared to the diacetyl-alpha-naphthol method. The enzymatic red cell creatine correlates with the erythrocyte survival time determined with the radioactive chromium method. It can be used as a rapidly available parameter for the quantification of hemolytic processes.

Adult↗
PubMed1987

[Recurrent menstruation-associated pneumothorax--catamenial pneumothorax].

The case of a 28-year old patient with a rare complication of an extensive endometriosis externa is described. A spontaneous pneumothorax occurred on 3 occasions corresponding each time with the start of the menstrual period. The various hypotheses on the aetiology and treatment of this rare condition are reviewed. To date only 65 patients with this interesting clinical entity have been recorded.

Adult↗
PubMed1987

[Problems in the psychiatric treatment of foreign patients].

The contribution deals with problems encountered during the psychiatric treatment of foreign patients, particularly with those from developing countries. It has been found that scope for socio- and psychotherapeutic treatment is very restricted and that the frequent necessity of returning these patients to their native countries leads to not unconsiderable conflicts. Questions of transcultural psychiatry are regaining importance in connection with increasing migration.

Acculturation↗
PubMed1986

Formation of prostacyclin and thromboxane in man as measured by the main urinary metabolites.

Excretion of 2,3-dinor-6-ketoprostaglandin F1 alpha and 2,3-dinorthromboxane B2, the main urinary metabolites of prostacyclin and thromboxane, was evaluated by gas chromatography-mass spectroscopy and radioimmunoassay, respectively, at various conditions in man. In healthy young males excretion of 2,3-dinor-6-ketoprostaglandin F1 alpha was of little variability, whereas urinary 2,3-dinorthromboxane B2 showed marked interindividual but moderate intraindividual variations. The ratio of urinary 2,3-dinorthromboxane B2 to thromboxane B2 in young males was about 15. Excretion of 2,3-dinor-6-ketoprostaglandin F1 alpha in women of reproductive age was higher (155 +/- 23 ng/g creatinine, P less than 0.005) than in postmenopausal women (97 +/- 24 ng/g creatinine) and in men (78 +/- 7.6 ng/g creatinine) and increased significantly during pregnancy (1st trimester 230 +/- 50 ng/g creatinine; 3rd trimester 522 +/- 53 ng/g creatinine). Urinary 2,3-dinorthromboxane B2 showed no gender differences and no directed change was observed during pregnancy. In neonates urinary 2,3-dinorthromboxane B2 (6.328 +/- 1.210 ng/g creatinine) was high in their 3rd day of life and decreased rapidly thereafter. This pattern paralleled the behavior of 6-ketoprostaglandin F1 alpha. In young male smokers and non-smokers excretion of 2,3-dinor-6-ketoprostaglandin F1 alpha was not significantly different, whereas urinary 2,3-dinorthromboxane B2 was elevated in smokers (609 +/- 61 versus 351 +/- 41 ng/g creatinine, P less than 0.001). Values are mean +/- S.E.

6-Ketoprostaglandin F1 alpha↗
PubMed1986

The effect of caffeine in the in vivo SCE and micronucleus mutagenicity tests.

Caffeine which was administered per os to outbred mice either twice, 30 and 6 h before sacrifice or once, 30 h before sacrifice, at dose levels of 50, 75 or 100 mg/kg body weight only caused a weak induction of micronuclei at the highest dose. Again a level of 100 mg caffeine per kg body weight was required before a weak but not significant effect could be observed in the micronucleus test using a mutagen-sensitive inbred strain of mice. In Chinese hamsters caffeine doses of 45, 75, 150 or 300 mg/kg body weight either given once or twice per os at the same time schedule as used for the mice also caused a clear cut induction of micronuclei only at the highest dose level. In the SCE test with Chinese hamster again 300 mg of caffeine were necessary to obtain a mutagenic effect although this test is considered to be more sensitive to mutagenic damage than the micronucleus test. It can therefore be concluded that caffeine causes DNA damage only at dose levels in the LD50 range which is higher for hamsters than for mice.

Animals↗
PubMed1985

[Initial clinical results of the prevention of intraoperative adhesions in children].

Postoperatively in 2 to 6% of all cases the result was an intestinal obstruction caused by adhesion. The usual measures were without permanent success. Intraoperatively we applied in 20 children streptokinase-streptodornase in the abdomen. During relaparotomy we saw no adhesions in 40% of these cases, whereas in a control group in all cases adhesions were found.

Abdomen↗
PubMed1985

Instant and brewed coffees in the in vitro human lymphocyte mutagenicity test.

Incubation of instant and 'home brew' coffees (caffeinated and decaffeinated) and of coffee aroma with cultured human lymphocytes in the presence and absence of S-9 increased the number of total aberrations. However, the increase was smaller in the presence of S-9 than in its absence. Pure caffeine tested with or without S-9 at doses equivalent to levels in caffeine-containing coffee did not give statistically significant increases of any type of aberration when compared with controls. In all in vitro test systems used to date, coffee and coffee aroma or their reactive compounds were metabolically deactivated in the presence of S-9. This could explain the negative results obtained in mutagenicity assays in vivo.

Animals↗
PubMed1984

Investigation of coffee in sister chromatid exchange and micronucleus tests in vivo.

Administration of a single oral dose of instant coffee to Chinese hamsters at levels up to 2.5 g/kg body weight did not increase the frequency of sister chromatid exchanges. Furthermore, five consecutive daily oral doses of instant coffee given to Swiss OF-1 mice up to 3 g/kg/day did not induce increases in micronuclei above spontaneous levels. Similarly, no effect was observed in the micronucleus test after mice received two oral doses of coffee aroma of up to 50 ml/kg.

Animals↗
PubMed1983

[Protein and amino acid digestibility in various sections of the digestive tract of swine. 2. Protein sources of plant origin].

Growing pigs provided with ileocaecal re-entrant cannulae were fed three rations containing plant protein sources and two N-free rations. The crude protein and amino acid flow in the digestive tract as well as the apparent and true digestibility of the crude protein and the amino acids for the individual sections of the intestines are explained. It shows that relating the calculation of metabolic faecal amino acids to live weight results in more realistic values than relating it to feed intake.

Amino Acids↗
PubMed1982

Characterization of a cellobiose dehydrogenase in the cellulolytic fungus Sporotrichum (Chrysosporium) thermophile.

An extracellular enzyme from culture filtrates of Sporotrichum (Chrysosporium) thermophile (A.T.C.C. 42 464) after growth on cellulose or cellobiose was shown to oxidize cellobiose to cellobionic acid in vitro. Lactose and cellodextrins were also efficiently oxidized, but the enzyme was not active against most mono- and di-saccharides. Several redox substances could act as electron acceptors, but molecular oxygen, tetrazolium salts and NAD(P) were not reduced. Activity was stimulated up to 2-fold in the presence of 0.05 M-Mg2+. The pH optimum of the enzymic reaction was acidic when the activity was tested with dichlorophenol-indophenol or Methylene Blue, but was neutral to alkaline for 3,5-di-t-butyl-1,2-benzoquinone or phenazine methosulphate as electron acceptors. As the enzyme was formed inductively in parallel with the endocellulase, its possible function in relation to cellulolysis is discussed.

Buffers↗
PubMed1982

Comparative levels of endogenous myelin basic protein-serum factors (MBP-SFs) in adult and suckling mice (B6CBAF1 and B6C3HF1, strains) and in neurologically mutant mice of the same genetic background.

Normal adult B6C3HF1 and B6CBAF1 mice contained at least 10 times higher levels (1.17 microM) of endogenous myelin basic protein-serum factors (MBP-SFs) than previously found in adult Lewis rats. In rat MBP-SF levels in the adult (0.03 microM) were much less than in the suckling animals (0.74 microM). In mice, by contrast, the adult (1.17 microM) and suckling (0.75 microM) levels were similar. Suckling mice from 9 different neurologically mutant strains and their clinically normal littermates had MBP-SF levels (0.5 microM) slightly below that of normal suckling mice of the same genetic background (0.75 microM).

Animals↗