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Biomedical subjects

H Meister

Publications and source records attributed to H Meister.

At least 19 recordsLinked to original sources
PubMed1979

[Prognostic aspects of early gastric carcinoma (author's transl)].

The results of treatment of early gastric carcinoma were analysed in 65 patients. In 33 patients the operation was performed 5 years ago. The 5-year-survival rate was 70%. Prognosis was predominantly influenced by the histology of the tumour. Signet ring cell and anaplastic early carcinomas (diffuse type) had a worse prognosis than intestinal (differentiated) forms. Carcinomas localised wholly in the mucosa had no better prognosis than those penetrating into the submucosa. There is no choice of surgical method according to prognostic criteria as the diagnosis "early gastric carcinoma" can be made only postoperatively from the resection material. Bioptic proof of carcinomatous gastric mucosal changes requires full observation of the rules of cancer surgery.

Biopsy↗
PubMed1979

Gastritis, intestinal metaplasia and dysplasia versus benign ulcer in stomach and duodenum and gastric carcinoma -- a histotopographical study.

In histological examination of gastrectomy specimens from patients with duodenal ulcer, gastric ulcer, and early and advanced cancer, both chronic atrophic gastritis and intestinal metaplasia were identified in 54% of the cases with duodenal ulcer. At 90 to 100%, respectively, these mucosal changes were approximately twice as frequent with gastric ulcer and early and advanced gastric cancer. Mild dysplasia occurred in 54% of the cases with duodenal ulcer; occurred somewhat more frequently with gastric ulcer, in 75% of the cases; and in almost all cases with early and advanced gastric cancer, at 90% and 100%, respectively. Whereas 27% of the cases with duodenal ulcer, 62% with gastric ulcer, and 90% and 95% of the respective cases with early and advanced gastric cancer showed moderate dysplasia, only severe dysplasia in early gastric cancer (40%) and advanced gastric (81%) was clearly more frequent in comparison to duodenal ulcer (9%) and gastric ulcer (12%). In the cases with duodenal ulcer chronic atrophic gastritis and intestinal metaplasia were limited mostly to the antrum; with gastric ulcer and cancerous stomach disorders, they also occurred in other stomach sections. Mild and moderate dysplasia conformed to the same distribution pattern. Severe dysplasia, which was only detected in two ulcer cases, was not only substantially more frequent in cases with early and advanced gastric cancer, but also showed a clear topographic relationship to cancer localization in the stomach.

Aged↗
PubMed1979

[Effects of ventilation with defined formaldehyde concentrations on lung function and lung structures. Animal experiments on the noxiousness of formaldehyde residues after disinfection in the aseptor (author's transl)].

Having seen the development of fatal pneumonias in ventilated patients, the cause of which was assumed to be the presence of residual traces of formaldehyde in the air in the respirator Kilian and Haug showed in 1973 initial formaldehyde concentrations up to 0.2 ppm in the ventilatory air of respirators correctly disinfected in the Aseptor. To study the effects of formaldehyde on lung function and lung structures, 23 young pigs were automatically ventilated with defined formaldehyde concentrations during 6 hours. The concentrations used were 0.02 ppm, 0.2 ppm and 2.0 ppm (double of the maximum permissible concentration). We found no differences in lung function, as shown by compliance measurements and arterial blood gas analysis. No radiological differences were in the thorax. Histologically, there were only slight alterations in lung structure in the group ventilated with double the maximum permissible concentration of formaldehyde. We conclude that the disinfection of respirators using formaldehyde in the Aseptor will remain the method of choice.

Animals↗
PubMed1979

Dysplasia of the lymphatics with lymphoedema, generalized lymphangiectasis, chylothorax and "pseudo-storage-disease".

A patient showing an unusual association of various abnormalities of the lymphatic vascular system is reported. These abnormalities became first evident in early childhood and consisted of lymphoedema of the left leg, lymphangiectasis in various organs and occlusion of the thoracic duct at its entrance into the venous angle. Chylous effusions and subcutaneous chyloedema appeared in adolescence. Diagnostic biopsies of spleen, liver and bone-marrow revealed the presence of multiple foamcells, suggesting the diagnoses of lipid storage disease. The patient died from severe honeycomb-lungs at the age of 20. This case cannot be attributed to one of the wellknown disease entities of the lymphatic system. The "pseudo"-storage disease is regarded as secondary to the backflow of chylus into the tissues.

Adolescent↗
PubMed1978

[Diagnostic and therapeutic aspects of early (superficial) gastric carcinoma: a retrospective analysis of 60 cases (author's transl)].

Among 947 patients operated on for gastric carcinoma between 1961 and 1976 there were 60 with early (superficial) gastric carcinoma. All but two patients consulted their doctor for diverse complaints. In one third of them treatment was delayed for a year or longer. In 26 of the 64 cancer foci it was limited to the mucosa. The correct diagnosis was made radiologically in 60%, gastroscopically in 70%. Selective endoscopic biopsy increased accuracy to 90%. The remaining false-negative findings occurred in the ulcerative form, which was the most frequent one. Improved radiological techniques (double-contrast) and obligatory gastroscopy with biopsy increased the relative proportion of early (superficial) carcinoma from under 4% in 1961 to 15%. The diagnosis of this type of carcinoma can be made only by careful histological study of the surgical specimens. Here as elsewhere in the surgery of carcinoma, multicentricity (in 5%) and possible lymph node metastases (10-20%) must be taken consideration in the surgical management.

Adult↗
PubMed1977

[Influence of duodenal reflux on the epithelium of the gastroenteral anastomosis (author's transl)].

The cancerogenic effect of continous duodenal reflux on the gastric mucosa has been investigated in male Wistar-rats after gastrointestinal anastomosis. Groups of animals with gastroenterostomy without enteroenteral anastomosis and with Roux-en-y-anastomosis preventing duodenal reflux were treated with lower dosages of the cancerogenic Nitrosoguanidine. Proliferative mucosal alterations near the gastroenteral anastomosis were observed. In addition the gastric mucosa was characterized by adenomatous lesions caused by duodenal reflux. The changes detected were not influenced by Nitrosoguanidine and did not appear in cases of Roux-en-y-anastomosis.

Adenoma↗
PubMed1977

[Esophageal replacement with lyophilized dura (author's transl)].

In 50 dogs thoracic or cervical esophagus was resected and the defect was replaced by a prosthesis made out of lyophilized dura. The healing process was studied radiologically and by clinical and histological examination. The experiments have proved the feasibility of bridging esophageal defects with lyophilized dura. The dura is replaced within 2 months by a tube of connective tissue. Until epithelialisation is complete there is a tendency to circular contraction. A stenosis could be prevented by dilatation or by means of a homologous-alloplastic esophageal prosthesis.

Animals↗
PubMed1977

[Tumors of the carotid body--diagnostic and therapeutic aspects (author's transl)].

The tumors of the carotid body are rare in frequency but still they give many problems in preoperative diagnosis and operative management. The pathological classification and estimation of dignity is still under discussion. Based on the experience of 5 patients we try to give a comprehensive listing of important facts and a classification for clinical use. In spite of the typical clinical signs which were described by Kocher and Fontaine the carotid body tumor is the most frequently mistaken tumor in the lateral region of the neck. If a tumor of this type is suspected a carotid arteriogram should be regularely performed. The arteriogram is the most important diagnostic procedure, and gives the final diagnosis in most cases. The therapeutic principle is the early total extirpation. In spite of the small rate of malignancy (under 10%) this challenge is based on the frequent observation of local spreading of the tumor. The excision of tumors of even large size is possible under consideration of special operative technics.

Angiography↗
PubMed1977

Role of Candida albicans in granulomatous tissue reactions. I. In vitro degradation of C. albicans and immunospecificity of split products.

Several mannan-containing fractions were obtained from whole cells, cell walls, and cytoplasm of Candida albicans by means of treatment with hot formamide or precipitation with (NH4)2SO4. The immunological and chemical characteristics of the fractions were compared with those of C. albicans mannan prepared by standard procedures. Antisera to C. albicans from rabbits immunized with whole cells of the organism were found to be primarily directed against the mannan content. With use of such antisera, mannan was localized in both the inner and outer layers of the cell wall, whereas the middle layer was found in all likelihood to represent the glucan polymer. Stepwise removal of mannan from whole cells or cell walls resulted in increasing loss of periodic acid-Schiff staining, immunofluorescence, and peroxidase reactivity. Thus, it appears that mannan is responsible for the ability of cell walls of C. albicans to be stained by periodic acid-Schiff or labeled with fluorescent antibody. The component of the pathogen most resistant to physical or chemical treatment was the glucan, which lacked all immunological reactivity.

Antigens, Fungal↗
PubMed1977

Role of Candida albicans in granulomatous tissue reactions. II. In vivo degradation of C. albicans in hepatic macrophages of mice.

Hepatic granulomas were induced in mice by injection of blastospores, cell walls, and glucan of Candida albicans. Granulomatous reactions in liver tissue initially multiplied but later decreased. A dose-response relationship was apparent with up to 3 mg of inoculum. Shortly after injection of C. albicans spores, fungal elements appeared in liver macrophages and were detectable in granuloma and Kupffer cells for 20 days. Gram-stain, periodic acid-Schiff (PAS), and immunofluorescence reactions soon vanished, and the organisms could no longer be seen. Glucan of C. albicans, which lacked PAS and immunofluorescence reactivity, proved active in initiation of granulomas. Degradation of phagocytized spores of C. albicans, reductions of cytoplasm, and cell wall deformation and collapse support the premise that loss of PAS and immunofluorescence reactivity was caused by enzymatic breakdown of candida cell wall mannan in macrophages. We conclude that C. albicans can induce granulomatous reactions in mouse liver when the glucan that forms the cell wall matrix in Candida persists in identifiable residues.

Animals↗
PubMed1977

[Histo-topography of gastric mucosa changes in benign and malignant stomach diseases].

The incidence and distribution of chronic gastritis, chronicatrophic gastritis and epithelial dysplasia I-III have been investigated in 50 resected stomachs of patients suffering from duodenal ulcer, gastric ulcer, early or advanced gastric cancer. Only in gastric cancer epithelial dysplasia III has been frequently observed, particularly in the neighbourhood of gastric cancer. Distribution of chronic-atrophic gastritis was similar to the distribution of dysplasia I and II. These mucosal lesions were detectable with the same frequency in patients with or without gastric cancer.

Chronic Disease↗
PubMed1977

[Hairy cell leukemia (author's transl)].

2 cases of hairy cell leukemia are reported. The disease is important for pathologists, because the splenomegaly is the leading clinical sign and often a splenectomy is performed with infomation about the true disease. The morphology of the spleen with infiltration of pulp cords and filling of sinuses by monomorphous blasts, with moderate fibrosis and atrophy of the white pulp is not convincing, because the hairy-like processes of the toumor-cell cytoplasm are not seen by usual histological examination. Hemocytomorphology and -cytochemistry are essential diagnostic procedures.

Adult↗
PubMed1976

[Experimental candida vaginitis in the mouse (author's transl)].

Manifest Candida albicans infection of the vagina of mice was achieved only after oestrogen treatment. Histologically, different phases of vaginal candidiasis could be observed: the mycotic infection began with a massive colonization of Candida albicans in the horny layers of the vaginal epithelium and an early immigration of granulocytes. Abscess-like changes followed when high number of yeast cells were used for infection. One to two weeks after onset the inflammatory changes decreased and fungi were no longer identifiable in epithelial micro-abscesses by the methods employed. In contrast, yeast cells could be detected within the vaginal skin exhibiting weak inflammatory lesions up to the 57th day. Chemotactic studies showed that the fungi considerably stimulated the migration of mouse granulocytes in the presence of serum. Since mannan isolated from the Candida cell wall also possesses strong chemotactic activity, certain components of the fungal cell wall may play a pathogenic role in Candida colpitis.

Animals↗
PubMed1976

Pathomorphologic findings in severe combined immunodeficiency and reticular dysgenesia.

Pathomorphologic findings in an 11 month old boy with severe combined immunodeficiency (case 1) and in a 4-month old boy with reticular dysgenesia (case 2) are reported. Case 1: The bone marrow exhibited regular granulo-, erythro- and thrombopoiesis. The hypoplastic thymus consisted exclusively of epithelial reticulum cells. The spleen and lymph nodes showed considerable depletion of lymphocytes in both the T- and B-cell areas. There was a complete lack of all lymphatic structures in the gastrointestinal tract and aplasia of the tonsils. Death resulted from Candida sepsis in conjunction with giant cell pneumonia closely resembling Hecht's pneumonia in measles. Case 2: The bone marrow showed a total lack of granulopoiesis. The storngly dysplastic thymus weighed only 1 g. The spleen, the lymph nodes and the gastrointestinal tract exhibited a very strange histologic structure resulting from a complete absence of lymphocytes and plasma cells. The tonsils were aplastic, the para-thyroid glands as well as the other endocrine glands were normally developed. The cause of death was Klebsiella sepsis and Pneumocystis pneumonia, the latter without the characteristic interstitial plasma cell infiltration. The importance of the immune system for activation of the nonspecific mechanisma of defense is discussed with respect to the two types of immunodeficiency states described here.

Agranulocytosis↗
PubMed1976

[Chronic myelosis].

After introducing remarks concerning the character of chronic myelosis and epidemiological data the clinical symptomatology and diagnostic criteria including differential diagnosis are discussed. The possibilities of the cytostatic or radiological therapy in the different stages of disease are explained.

Adult↗