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Biomedical subjects

H Miles

Publications and source records attributed to H Miles.

26 records · Page 2Linked to original sources
PubMed1981

The role of the laboratory in the planned use of cefoperazone for the treatment of difficult Pseudomonas infections.

Four cases are discussed illustrating the role of the laboratory in the treatment of difficult pseudomonas infections. Pseudomonas vertebral osteomyelitis, in a 76-year-old man with impaired renal function, was successfully treated with cefoperazone given for 7 weeks. A 73-year-old woman, who had recurrent pseudomonas septicaemia due to infected cardiac pacing wires (that could not be removed), was managed with long term daily intramuscular cefoperazone, and a 31-year-old woman with pseudomonas aortitis was treated with long term intravenous cefoperazone. A 47-year-old man, who developed a pseudomonas infection superimposed on chronic osteomyelitis of the femur prior to a free vascularised graft operation, was treated with cefoperazone and ticarcillin.

Adult↗
PubMed1980

Drug trials: treatment of urinary tract infection with multiple-dose intramuscular administration of cephamandole.

Therapy with cephamandole (1.0 g, every eight hours) for five days was effective in eliminating cephamandole-sensitive microorganisms from the urinary tract. A 75% cure rate was achieved in a group of 20 patients, 45% of whom had abnormalities of the urinary tract. Local pain (despite addition of lignocaine) was sufficiently prolonged and severe to make multiple-dose intramuscular administration unacceptable. No other toxic effects were encountered.

Anti-Infective Agents, Urinary↗
PubMed1980

Microbiology of acute otitis media with particular reference to the feasibility of pneumococcal immunization.

Middle-ear fluid was aspirated in 103 episodes of acute otitis media occurring in 100 South Australian children aged from four months to 14 years in 1977, and in 1978. Bacteria were cultured from the middle-ear fluid in 66% of cases, and viruses were grown in three cases in conjunction with bacteria. The bacteria grown were pneumococci in 30 cases (29%), Haemophilus influenzae in 26 cases (25%), beta-haemolytic streptococci in 12 cases (12%) and Neisseria spp. in six cases (6%). Pneumococci and H. influenzae were cultured from children of all ages, whereas beta-haemolytic streptococci were more frequently isolated in children aged five years and older. Countercurrent immunoelectrophoresis yielded positive results in 35% of culture-positive pneumococcal infections and gave additionally the positive reaction for pneumococci in two cases where culture produced negative results. The pneumococci which were isolated belonged to 12 serotypes; 26 of the 30 isolates were serotypes for which pneumococcal vaccines are currently available. There were appreciable differences in the distribution of serotypes from that encountered in a study of nasal carriage amongst healthy schoolchildren living in the same district.

Acute Disease↗
PubMed1980

A study of cefoperazone alone and in combination with tobramycin against Pseudomonas aeruginosa.

The minimum inhibitory concentrations (MICs) of cefoperazone for 507 clinical isolates of Pseudomonas aeruginosa were measured by plate dilution technique. On a cumulative percentage basis, 81% of isolates were inhibited by less than or equal 3.13 microgram/ml of cefoperazone. The minimum bactericidal concentration (MBC) was found to be generally twice the MIC. Synergy occurred between cefoperazone and tobramycin, judged by a lowering of the MIC in 69% of isolates, for which the MIC of cefoperazone alone was less than or equal to 6.2 microgram/ml.

Anti-Bacterial Agents↗
PubMedDate not supplied

Performance of the CardioChek PA and Cholestech LDX point-of-care analysers compared to clinical diagnostic laboratory methods for the measurement of lipids.

Point-of-care (POC) blood testing is intended to provide results more rapidly than can be obtained from a central laboratory. Precision and accuracy of the CardioChek PA and Cholestech LDX analysers were compared to clinical diagnostic laboratory methods. In 100 patients, total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) levels were measured by both analysers and compared to those analysed by the National Health Laboratory Service (NHLS) laboratory. Data were evaluated for conformance with National Cholesterol Education Program (NCEP) guidelines. Results were grouped into low, middle and high ranges and were similar to those obtained by the NHLS, except in the high range where TC and LDL-C levels were under-read by both analysers. All analytes measured by both analysers correlated significantly with NHLS (p < 0.0001). With the exception of LDL-C, both analysers showed reasonable compliance with NCEP goals for coefficients of variation and bias measurements. Both analysers met NCEP guidelines for all analytes at two clinical cut-off points. We concluded that, compared to NHLS methods, performance of the CardioChek PA and Cholestech LDX analysers is acceptable and that they offer healthcare professionals a rapid, POC method for the measurement of lipids.

Biomarkers↗