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Biomedical subjects

H Mion

Publications and source records attributed to H Mion.

At least 37 records · Page 2Linked to original sources
PubMed1981

Middle molecule accumulation in uremia: an "extra uremic factor".

To evaluate middle molecule (MM) accumulation in relation with patients' well-being, plasma MM were analyzed in 115 uremic patients by using the two-step chromatographic technique described by Fürst et al. Unexpectedly, most of the patients exhibited small or undetectable subpeaks 7a, 7b, 7c, 7d. However, patients on regular dialysis treatment tend to present higher MM concentrations when a complication, such as infection, hyperparathyroidism, symptomatic neuropathy, or intercurrent disease occurs and peak 7d was very prominent after radio-contrast media administration. No correlation was found between plasma MM and small molecule accumulation (urea, creatinine, and uric acid) or residual renal function or hematocrit. An unexpected correlation was found between some MM fractions and serum PTH. These results indicate that MM do not accumulate in plasma only as a result of impaired renal function. This suggests considerable variations in their generation rates may be due to unknown misleading artifacts, PTH breakdown products, or other factors.

Adolescent↗
PubMed1980

Aluminium transfer in bicarbonate dialysis using a sorbent regenerative system: an in vitro study.

Because of the known presence of aluminium oxide in the Redy cartridge and the increased solubility of aluminium (A1) in alkaline solution, an in vitro study was performed to measure the release of A1 from the Redy cartridge and its potential transfer across a dialyser membrane. The use of bicarbonate rinsed Redy cartridges was associated with significant release of A1 and its subsequent transfer across the cellulose acetate membrane. Bicarbonate dialysis with the Redy system is not recommended for maintenance haemodialysis.

Acetates↗
PubMed1980

[Kinetics of ultrafiltration in peritoneal dialysis with long dialysate dwell: an "in situ" study (author's transl)].

In order to measure in situ the kinetics of peritoneal ultrafiltration in peritoneal dialysis (PD) with long dialysate dwell, a colorimetric method using autologous hemoglobin as a marker added to the dialysis fluid was evaluated in 10 patients on PD for periods ranging from 2 weeks to 20 months. Four different dialysate formulae were successively tested in the same patient. The results expressed as normalised ultrafiltration coefficient (UFK, ml/min/1.73 m2 s.a.) showed a wide scatter among the patients. However, the dilution curves successively obtained with dialysis fluids of varying osmolar concentration in the same patient were very consistent with each other, indicating that UFK was a characteristic of the individual peritoneal membrane. The data presented suggest that UFK should be measured in each patient at initiation of PD in order to prescribe the dialysate formulae and the diffusion times fitting best his individual needs. On the other hand, repetitive measurements of UFK in the same subject would allow a useful analysis of the hydraulic permeability of the peritoneum by detecting any significant change in this parameter during long term PD.

Adult↗
PubMed1978

Sorbent regeneration of ultrafiltrate as a long-term treatment of end-stage renal failure.

A sorbent system (Redy D 11 cartridge) capable of on-line regeneration of ultrafiltrate during hemofiltration (Amicon 0.5 m2) has been developed and applied on a 3 X 4 hr/week schedule to three patients with end-stage renal failure previously treated for up to six months with hemodialysis. Total experience, to date, is sixteen patient months (three to seven months). Tolerance to fluid removal improved with the new system. Patient well-being and rehabilitation have been maintained. The system offers the potential of hemofiltration without sterile replacement fluid or expensive fluid-balancing machines.

Aluminum↗
PubMed1978

Haemofiltration with sorbent regeneration of ultrafiltrate: first clinical experience in end stage renal disease.

A sorbent system (Redy D11 cartridge) capable of 'in line' regeneration of ultrafiltrate during haemofiltration (Amicon 0.5 m2) has been developed and applied on 3 X 4 hr/week schedule to 3 patients with end stage renal failure previously treated for up to 6 months with haemodialysis. Total experience, to date, is 8 patient months. Tolerance to fluid removal improved with the new system. Patient well being and rehabilitation has been maintained. The system offers the potential of haemofiltration without sterile replacement fluid or expensive fluid balancing machines.

Adult↗