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Biomedical subjects

H Mirchandani

Publications and source records attributed to H Mirchandani.

11 recordsLinked to original sources
PubMed1991

Human immunodeficiency virus infection in cases presenting to the Philadelphia Medical Examiner's Office.

Serum samples were available from 492 of 1,058 cadavers seen at the Philadelphia Medical Examiner's Office between August 4 and December 15, 1989. These sera were tested for the presence of antibodies to human immunodeficiency virus (HIV) by enzyme-linked immunosorbent assay (ELISA) and Western blot. The overall prevalence of HIV in the autopsy population was 2.24%. The following populations showed increased prevalence as compared to the total sampled population: blacks (3.60%, p less than 0.01), males (2.51%, n.s.), and homicide victims (3.74%, n.s.). Seroprevalence data from this study are compared with those from earlier studies of other related populations, with regard to overall prevalence and risk factor analysis.

Black or African American↗
PubMed1990

Death as a result of asthma in Wayne County Medical Examiner cases, 1975-1987.

All deaths ascribed to asthma in the 5-to-40-year age group at the Wayne County Medical Examiners' Office were reviewed from 1975 to 1987 inclusive. Fifty-eight deaths were attributed solely to asthma, and the annual number increased fivefold in the 1980s to a rate of approximately 0.5 per 100,000 per year when extrapolated to the Wayne County population. Blacks were overrepresented to double their proportion in the general population. Almost all cases were known asthmatics, and many had received previous emergency care. Most fatalities occurred at night and did not demonstrate any seasonal variation. The onset of the fatal attack was apparently very rapid in most cases, with many engaged in routine activities and few surviving any length of time in hospital or having sought treatment earlier. Our data reveal a significant increase in sudden death in previously well asthmatics in Wayne County in the 1980s. Similar increases in deaths as a result of asthma have been noted previously in other countries for reasons that remain unclear.

Adolescent↗
PubMed1988

Single gunshots with multiple entrances.

Single gunshots can cause multiple entrance wounds, almost always after the bullets have first struck intermediate targets. The phenomenon is commonly seen with relatively high-velocity jacketed ammunition and consequent separation of jacket and core. We herein present two representative cases with a discussion of the mechanism of injury.

Adult↗
PubMed1988

Fatality from illicit phendimetrazine use.

Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug. Methods of detecting and identifying this drug in urine and blood are discussed. In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

Adult↗
PubMed1987

Intravenous leiomyoma with intracardiac extension causing sudden death.

A 43-year-old woman with a three-year history of syncope is described. No cause for her symptoms was discovered until a postmortem examination revealed an intravenous leiomyoma within the left renal vein that extended to the right ventricle of the heart. A review of the literature is presented.

Adult↗
PubMed1986

Immunohistochemical demonstration of homicidal insulin injection site.

Deliberate fatal injection of insulin is apparently a rare event. Its investigation generally requires demonstration of an exogenous insulin injection site and high blood or tissue levels. Interpretation of such results in postmortem samples can be difficult, and the demonstration of an insulin injection site has previously usually involved a tedious extraction procedure. We report a case of infanticide in which insulin was demonstrated immunohistochemically at the fatal injection site and discuss some aspects of interpretation of postmortem insulin levels.

Autopsy↗
PubMed1985

Middle cerebral artery reconstruction.

The authors have conducted an experimental study of the microanatomic features of the middle cerebral artery in unfixed human brains to assess the feasibility of reconstructive procedures within the Sylvian fissure. It was found that reconstructive procedures within the Sylvian fissure such as end-to-end, end-to-side, side-to-side, and grafting procedures were possible according to the anatomic data provided by our study. Possible surgical solutions to theoretical pathologic situations involving the middle cerebral artery vascular tree are highlighted and their feasibility is discussed.

Cerebral Arteries↗
PubMed1985

Fatal malignant hyperthermia as a result of ingestion of tranylcypromine (Parnate) combined with white wine and cheese.

Fatal malignant hyperthermia occurred in a patient who was taking tranylcypromine (Parnate) and ingested wine and cheese. The case findings are presented along with a review of the literature concerning adverse interactions between monoamine oxidase (MAO) inhibitors and certain foods and beverages. Hyperthermia and its possible causative mechanisms and treatments are discussed. The facts suggest that the complicated dietary restrictions attending the use of MAO inhibitors and the possibility of severe and even catastrophic reactions resulting from violations of these restrictions make the use of these drugs fraught with danger and therefore not a first choice for the treatment of depression.

Adult↗
PubMed1984

Commotio cordis, revisited.

Nonpenetrating cardiac injuries due to direct precordial blunt impacts are a commonly encountered phenomenon in medicolegal offices. These injuries vary from contusions to valvular lacerations, or papillary muscle rupture to coronary arterial injury with resulting infarction. A less commonly occurring manifestation of nonpenetrating injury is a concussion of the heart (commotio cordis), often with dramatic physiological consequences but no morphologic cardiac injury. We describe four case reports of this entity. The cases were collected over a 5-year period (1978-1983) from the Wayne County Medical Examiner's Office in Detroit, Michigan.

Adolescent↗
PubMedDate not supplied

A death involving fentanyl.

Selected ion monitoring gas chromatography/mass spectrometry was employed to quantitate fentanyl in blood, liver, and kidney from a death attributed to a fentanyl overdose. The concentration of fentanyl was 3 ng/mL blood, 11 ng/g liver and 14 ng/g kidney.

Adult↗