[Biochemical analysis of neurotransmitters in temporal lobe and limbic system of post-mortem brains from schizophrenic patients].
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Aged↗
Biomedical subjects
H Mitsushio
Publications and source records attributed to H Mitsushio.
[Biochemical analysis of neurotransmitters in substantia nigra, nucleus ruber, nucleus subthalamicus and thalamus of post-mortem brains from schizophrenic patients].
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Adult↗
[Biochemical analysis of neurotransmitters and receptors in prefrontal cortex of post-mortem brains from schizophrenic patients].
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Application of one-phase end-point change system in two-phase titration to amine drug analysis.
A titration method was developed for the determination of diphenhydramine, quinine, neostigmine, sparteine, strychnine, homatropine, atropine, physostigmine, and procaine in aqueous solution. Tetraphenylborate was used as a titrant with tetrabromophenolphthalein ethyl ester as an indicator in the presence of organic solvent. End-point detection was based on the color change of the indicator in the organic phase without movement of the indicator from one phase to the other.
Amines↗
Habenular modulation of dynorphinergic systems in rat ventral mesencephalon.
Bilateral electrolytic lesion of the striatonigral pathways (which convey massive afferents to the substantia nigra) caused a marked lowering of alpha-neo-endorphin (alpha-Neo) and dynorphin A(1-8) [Dyn A(1-8)] levels in the substantia nigra without affecting the alpha-Neo content in the ventral tegmental area. Moreover, unilateral infusion of the axon sparing neurotoxin ibotenate into the striatum, but not into the substantia nigra, decrease these two opioid peptides in the substantia nigra on the side ipsilateral to the lesion, failing to modify the alpha-Neo levels in the ventral tegmental area. Bilateral electrolytic lesion of the habenula augmented alpha-Neo content in the substantia nigra and ventral tegmental area at 8-30 days postlesion without affecting the nigral Dyn A(1-8). These results add further support to the view that alpha-Neo- and Dyn A(1-8)-containing neurons projecting to the substantia nigra originate in the striatum and descend through striatonigral pathways. The present data provide evidence that the habenula may participate in the regulation of the activity of alpha-Neo-immunoreactive neurons in the substantia nigra and ventral tegmental area.
Animals↗