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Biomedical subjects

H Mobacken

Publications and source records attributed to H Mobacken.

At least 91 records · Page 5Linked to original sources
PubMed1979

Chronic non-scarring folliculitis of the scalp.

Forty patients with recurrent follicular pustules of the scalp but without obvious necrosis or residual scarring were re-examined (mean 8.3 years after onset of lesions). The most common age at onset was 20-40 years. The sex ratio (M/F) was 3 : 1. Only 7 of 40 patients had concomitant acne vulgaris on the face. All patients still had active, recurring scalp lesions, although 7 out of 40 had had temporary remissions. Post-lesional scarring was not observed. Oral low-dose tetracyclines had a symptomatic effect in 7 of 11 patients. Most of the patients treated topically with steroids and alcoholic lotions experienced little or no effect. Histopathology disclosed a neutrophilic folliculitis. Bacteriological examinations showed only the usual resident microflora of the scalp with P. acnes being the most frequent species. In 3 cases (5 examined pustules), P acnes was isolated from the content of the pustules without being found on the skin surface over the pustule. Chronic non-scarring folliculitis of the scalp probably constitutes a disease entity.

Adolescent↗
PubMed1978

Depressed non-specific lymphocyte reactivity in psoriasis.

T-lymphocyte number and functions were studied in 24 patients with psoriasis guttata as compared to healthy controls. A decrease was found of the in vitro ability to synthetize DNA in response to stimulation with phytohemagglutinin (PHA), concanavalin A, poke weed mitogen and PPD, which was statistically significant for PHA. The percentage and absolute numbers of both T and B peripheral blood lymphocytes were not altered.

Adolescent↗
PubMed1978

Development of gastric dysfunction in dermatitis herpetiformis.

In order to study the development of atrophic gastritis, gastric secretory function was examined by a standard pentagastrin test 24 to 78 months after a previous examination (Ex I). The study included 12 patients with dermatitis herpetiformis (DH), 6 patients with functional signs of atrophic gastritis previously, and 8 healthy controls. The surrent examination (Ex II) also included microbiological culture of gastric juice and estimation of gastrin(s), parietal cell and thyroidal antibodies. Most of the controls had increased their maximum acidity and maximum acid output (MAO) between the examinations. This may indicate an altered potency of pentagastrin in recent years. Conversely, 5 of the 6 patients with atrophic gastritis showed a further reduction of maximum acidity and MAO, indicating progressive parietal cell atrophy. In the DH-group, two tendencies were observed: 6/12 patients had an increased MAO at Ex II. They had had lower mean age and higher mean MAO at Ex I, as compared with the remaining 6 patients who had a decreased MAO at Ex II. The latter group more often had parietal cell antibodies.

Adult↗
PubMed1978

Neutrophil granulocyte function in pustulosis palmoplantaris.

The phagocytic bactericidal capacity of circulating neutrophilic granulocytes was estimated in 22 patients with pustulosis palmoplantaris (PPP). The control group comprised 100 healthy individuals. Leukocytes from the patients had a statistically significant reduced capacity to kill Staph. aureus in autologous as well as in AB serum. Leukocyte killing of E. coli was not reduced. Serum levels of total hemolytic complement, C3, C4 and neutrophil myeloperoxidase activity were normal. The findings suggest an intrinsic or cellular defect of circulating neutrophil granulocytes in patients with PPP.

Adult↗
PubMed1977

Xeroderma pigmentosum--biochemical and therapeutic aspects. Case report.

Four patients with Xeroderma pigmentosum are reported: 2 diagnosed following the development of multiple cutaneous tumours, and 2 at an earlier state. The repair synthesis of DNA after ultraviolet radiation was reduced in 3 and normal in 1 patients. Para-aminobenzoic acid (PABA) was used topically as sunscreen; for those intolerant to PABA, alternatives are given. 5-fluoro-uracil had satisfactory effect against actinic keratoses. Two patients had associated neurologic and mental abnormalities compatible with deSanctis-Cacchione syndrome, a Xeroderma pigmentosum variant.

4-Aminobenzoic Acid↗
PubMed1977

Deficient neutrophil function in a patient with chronic mucocutaneous candidiasis, thymoma and myasthenia gravis.

The case of a 68-year-old man who suffered the onset of chronic mucocutaneous candidiasis, thymoma, myasthenia gravis and a reversible neutrophil dysfunction during adult life is reported. All tests for humoral and cellular immunity proved normal. Thymectomy and the administration of transfer factor had no effect on the skin disease. Long-term oral administration of 5-fluorocytosine almost cleared the skin lesions; the neutrophil defect disappeared.

Aged↗
PubMed1977

Iron absorption in patients with dermatitis herpertiformis.

Iron absorption has been studied in patients with dermatitis herpetiformis (DH). Four patients out of 20 had iron deficiency, defined as absence of or only traces of haemosiderin in bone marrow smears. These four had adequate absorption of ferrous iron. The iron deficiency in at least 3 of them was ascribed to increased iron loss. The results indicate that, although having a mild to moderate malabsorption syndrome, DH patients can be expected to exhibit adequate absorption of orally administered iron. Explanations of a negative iron balance other than defective absorption should therefore be sought.

Adolescent↗
PubMed1977

Microvascular effects of a topically applied cationic triphenylmethane dye (crystal violet).

The effects of local application of crystal violet on the microcirculatory system are reported. The testing system consisted of vital microscopy of the cheek pouch of the hamster and microangiography of rabbit's ear. It appeared that the early microcirculatory disturbances caused by a dilute aqueous solution of crystal violet were transient, whereas considerable tissue toxicity was shown in the long-term experimental model. A direct cytotoxic effect is suggested.

Angiography↗
PubMed1976

Auto-immune atrophic gastritis in patient with dermatitis herpetiformis.

Seventeen patients with dermatitis herpetiformis were tested for gastric hydrochloric acid secretion. Seven were found to be achlorhydric. Atrophic gastritis in these patients probably had an auto-immune pathogenesis, as judged by elevated serum gastrin level, high prevalence of antibodies against gastric parietal cells and antrum sparing of the gastric atrophy. This type of atrophic gastritis is considered to indicate a precursor state to pernicious anemia.

Adult↗
PubMed1976

Recurrent bullous eruptions on the lower legs.

In 15 patients with venous or arterial insufficiency of the legs, bullous eruptions were observed on the lower legs. The bullae were subepidermally situated. Circulating antibodies against the basement membrane zone were not demonstrated in 2 cases investigated. This eruption seems to represent a clinical entity of unknown etiology.

Aged↗
PubMed1975

Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone).

Twenty patients with dermatitis herpetiformis treated with di(4-aminophenyl)-sulphone (Dapsone) were analyzed with respect to serum hemopexin concentration as well as some other haematological parameters. With one exception, there were normal concentrations of serum hemopexin when the haptoglobin and methaemoglobin concentrations were normal. Ten out of 11 patients with haptoglobin below 0.3 g/l, which is the lower limit of reference interval at this laboratory, had their hemopexin concentrations reduced to various extents. There was an inverse relationship between the concentration of serum hemopexin and blood methaemoglobin. There was no correlation between amount of Heinz bodies and the concentrations of blood methaemoglobin, serum haptoglobin or serum hemopexin. It is concluded that serum hemopexin measurement should be of value in the assessment of the severity of the haemolysis caused by the drug treatment in those cases who have a low serum haptoglobin concentration.

Adult↗