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H Mochmann

Publications and source records attributed to H Mochmann.

At least 37 records · Page 2Linked to original sources
PubMed1984

[A type strain or a neotype strain of Leptospira].

A deep review of the scientific literature concerning the history of the two oldest icterohaemorrhagiae strains is given in order to promote a decision about the legitimate neotype strain on the genus Leptospira. The strain RGA was found to meet completely the requirements for a Neotype culture given by the International Code of Nomenclature of Bacteria. Its origin from a patient with Weil's disease through guinea pig passages in 1915 is well documented and its culture is unequivocally described by Ungermann in 1916. The strain was maintained in pure culture. Since more than 60 years the strain is used for comparative investigations in classification studies in all laboratories performing such tests. At contrary the history of strain Ictero I is very incomplete. The strain was claimed by Yamamoto to be one of the strain isolated by Inada and Ido in 1915 originally designated as Yamasaki. However, the statement the maintenance of these strains because of loss of virulence was discontinued, is repeatedly mentioned in some old publications of the authors. Moreover it is reported that the strain Ictero I because of contamination with a fungus was recultivated after a passage through a splenectomized mouse, i.e. the strain was not maintained in a pure culture. Beside this it is hardly understandable why has the strain not been submitted to other laboratories before 1965. The strain Ictero I was found to contain an additional thermolabile antigen not present in RGA. At present it is impossible to decide whether this property was already present in the original culture or developed only later, eventually after its mouse passage. Summarizing all these facts, it must be stated that the strain Ictero I cannot be considered to meet all the necessary requirements of its recognition as neotype culture of the Genus Leptospira.

Bacteriology↗
PubMed1980

[Escherichia coli O151:K-:h10 ("krim") as etiologic agent of diarrhoea (author's transl)].

The first time infections by Escherichia coli O 151:K-:H10 were reported from Japan and the Soviet Union. 1972 it was included into the international antigenic scheme. Since 1976 these germs were occasionally demonstrated in sporadically occurred acute enteritis in th G.D.R. In autumn 1979 60 E. coli O 151 strains were isolated from accumulating cases of gastroenteritis in the Rostock district. These infections mainly concerned young children, but also adults. Microbiological properties of 87 isolates of this serogroup are described. Biological examination of these strains did not result in symptoms for invasive activity or enterotoxin production. An indirect reference to the existence of fimbrial antigens could be obtained by the Evans' method of direct hemagglutination. A corresponding hemagglutination pattern was found out in 60 E. coli O 151 strains tested: mannoseresistent hemagglutination of bovine and chicken erythrocytes. Hemagglutination pattern, association of these strains with enteritis and antigenic relations of Salmonellae motivated the recommendation to integrate these germs into the group of facultatively enteropathogenic Escherichiae coli described by Czirók and Evans. E. coli O 151 strains show biochemical particularities which can be useful for identification of these strains.

Adolescent↗
PubMed1980

[The protective effect of an EDTA-sodium-extract-vaccine obtained from swine-pathogenic E. coli in a field trial. 1. Communication: Direct and indirect immunization of suckling piglets (author's transl)].

Pentavalent EDTA-Sodium-extract-vaccines and monovalent EDTA-Sodium-extract-vaccines obtained from swine-pathogenic E. coli and produced in Berlin-Buch were used in field trials to test their antiepizootic effect in industrial pig-farms in the district of Wrocław. The pentavalent vaccine contained extracts from E. coli O138, O139, O141, O147, and O149, whereas extracts from O8, O115 and O149 were used as monovalent vaccines. The field trials were conducted as blind trials is closed stocks of pigs. We employed direct oral immunization of suckling piglets and indirect immunization via sow vaccination. Direct oral immunization was tested in 382 suckling piglets. 190 animals were vaccinated, 192 animals received placebo. Neither the pentavalent vaccine nor a monovalent vaccine obtained from an epizootie strain of this stock gave protection in terms of a decrease in the duration of disease or a reduction of morbidity and mortality. Direct oral-immunization of suckling piglets thus was ineffective. Indirect immunization of the suckling piglets via vaccination of sow was performed in 189 pregnant sows 18--15 days before farrowing. 84 sows received vaccines i.m., 105 were given placebo i.m. These sows farrowed 1717 pigs, 777 of which were immunized indirectly and 940 treated with placebos. With the pentavalent vaccine and with the monovalent vaccine obtained from an epizootic strain we achieved significant protection of the indirect vaccinated suckling piglets.

Administration, Oral↗
PubMed1980

[The protective effect of an EDTA-sodium-extract-vaccine obtained from swine-pathogenic E. coli in a field trial. 2. Communication: Immunization of weanling piglets (author's transl)].

Pentavalent EDTA-Sodium-extract vaccines and monovalent EDTA-Sodium-extract vaccines obtained from swine-pathogenic E. coli were used to test their antiepizootic effect in industrial pig farms, 2929 piglets after weaning were included in this field trial, 1309 were immunized partly orally, partly i.m., 1620 piglets received placebos accordingly. By means of oral immunization the pentavalent vaccine was capable of reducing the morbidity of the vaccinated animals significantly. Intramuscular immunization with the pentavalent vaccines produced significant differences in morbidity too. A monovalent vaccine obtained from E. coli O149 and E. coli O8 was shown to be equally effective, whereas a monovalent vaccine obtained from E. coli O115 was ineffective. But in this stock there were infections with O149 but none with O115 or O8.

Administration, Oral↗
PubMed1979

[Preliminary results of an atiepizootic field test using EDTA-Na extract vaccine from Escherichia coli strains pathogenic to swine in swine production industrial units].

An anti-epizootic field test was applied to industrialised pig farms in the region of Wrocław, Poland, to test the effectiveness of a pentavalent EDTA (calcium disodium edetate)--sodium vaccine extracted from Escherichia coli strains with pathogenicity to swine. The vaccine had been received from a centre in Berlin-Buch, GDR. The vaccine failed to provide any protection, when orally applied to nursed piglets. However, both morbidity and mortality were reduced and, thus, an anti-epizootic effect on nursed piglets produced, when the vaccine had been injected intramuscularly to the pregnant mother animals, prior to farrowing. In weaned piglets morbidity was sucessfully reduced by both oral as well as intramuscular administration.

Administration, Oral↗
PubMed1979

[Rotavirus diarrhea in childhood].

Electron microscopy of 350 diarrhoeal faeces revealed Rotavirus-particles in 145 cases. All patients with Rotavirus-infections showed symptoms of acute gastroenteritis lasting 1 to 8 days. Additionally to diarrhoea most cases presented fever and vomiting. None of the patients showed toxicosis.

Child↗
PubMed1978

[Laboratory experiments with a polyvalent extract vaccine for oral immunization against E. coli enteritis].

Bacteria of E. coli causing enteritis can be extracted by EDTA-sodium. These extracts having lower dry weights result in better protective effects in contrast to sodium-deoxycholate extracts. The EDTA-sodium extracts can be concentrated, purified and sterile filtrated. Thus the production of polyvalent vaccines is possible. A direct relation exists between the effectiveness of the extracts and the virulence of the strains used for extraction. The more virulent the original strain the better is the protective effect of the vaccine produced by extraction of the original strain. The single components of the polyvalent vaccine show a certain improvement of their protective effects. For estimating the immunizing dose, it is necessary to consider the limiting dose. When exceeding this dose the protective effect or the vaccine does not further increase but remains constant of even decreases. The immunizing dose wanted must be greater than the ED50 but smaller than the limiting dose. Extremely high oral doses of vaccine result in symptoms of incompatibility in mice.

Administration, Oral↗