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Biomedical subjects

H Morehouse

Publications and source records attributed to H Morehouse.

11 recordsLinked to original sources
PubMed1999

The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein.

Two high copy suppressors of temperature-sensitive TATA-binding protein (TBP) mutants were isolated. One suppressor was TIF51A, which encodes eukaryotic translation initiation factor 5A. The other high copy suppressor, YGL241W, also known as KAP114, is one of 14 importin/karyopherin proteins in yeast. These proteins mediate the transport of specific macromolecules into and out of the nucleus. Cells lacking Kap114 partially mislocalize TBP to the cytoplasm. Kap114 binds TBP in vitro, and binding is disrupted in the presence of GTPgammaS. Therefore, Kap114 is an importer of TBP into the nucleus, but alternative import pathways must also exist.

Amino Acid Sequence↗
PubMed1995

The association between tuberous sclerosis and insulinoma.

We describe a patient with tuberous sclerosis and an insulinoma. The neurologic abnormalities typically present in patients with tuberous sclerosis may, in rare cases, be manifestations of hypoglycemia. We discussed a possible association between tuberous sclerosis and multiple endocrine neoplasia type I.

Adult↗
PubMed1984

Sonography and computed tomography in the diagnosis of carcinoma of the gallbladder.

The computed tomographic and sonographic findings of 26 patients with gallbladder carcinoma were reviewed, and the problems and pitfalls encountered with these imaging techniques are discussed. The most common finding, a mass filling or replacing the gallbladder, was seen in 42% of the patients. A mass protruding into the gallbladder was seen in 23%, and diffuse asymmetric thickening of the gallbladder wall in 15%. Recommendations are made to avoid some of the diagnostic problems encountered. With careful and meticulous technique early carcinoma of the gallbladder may be detected with greater frequency by cross-sectional imaging techniques.

Aged↗
PubMed1983

Hematuria secondary to left peripelvic and gonadal vein varices.

The nutcracker syndrome refers to compression of the left renal vein between the aorta and superior mesenteric artery which results in renal vein and left gonadal vein varices. This is an unusual but well accepted cause of hematuria. We report a case of the nutcracker syndrome and present the radiologic workup including computerized tomography (CT) and renal venography with venous pressure measurements.

Adult↗
PubMed1979

Local duodenal metastasis from colonic carcinoma.

The clinical and radiologic appearance of an isolated metastasis to the duodenum may mimic a primary pancreatic or duodenal cancer. As lymphatics from the right colon drain to periduodenal lymph nodes, lymphatic spread from right colon cancer can cause enlargement of the duodenal loop, with ulceration or distortion of the mucosa on the medial aspect of the duodenum. We present three patients with ulcerating metastases in the duodenum from colon cancer whose cases exemplify the problems of diagnosis and management.

Adenocarcinoma↗
PubMedDate not supplied

Magnetic resonance imaging of dissection in pseudocoarctation of the aorta.

Two patients with pseudocoarctation complicated by dissection are presented. They are the first cases in which pseudocoarctation with dissection have been imaged by magnetic resonance (MR). MR imaging is an excellent noninvasive modality in the evaluation of dissection in pseudocoarctation of the aorta.

Adult↗
PubMedDate not supplied

CT of pancreatitis with renal and juxtarenal manifestations.

Involvement of the juxtarenal spaces and kidneys in pancreatitis has been well known. Although delineation of the regions of accumulation of exudate has been elegantly confirmed with the advent and advance of refined computerized tomography (CT) there has been relatively little description in the earlier literature of these phenomena. This essay serves to illustrate the wide range of findings that have been encountered and recorded more recently.

Adrenal Glands↗