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Biomedical subjects

H Morrison

Publications and source records attributed to H Morrison.

At least 91 records · Page 5Linked to original sources
PubMed1976

Thyrotropin releasing hormone: antagonism of pentobarbital narcosis in the monkey.

The effect of TRH on pentobarbital narcosis in 21 rhesus monkeys was examined. Vital signs monitored included respiration rate, heart rate, temperature, sleeping time,and time of reappearance of certain reflexes. Blood samples were obtained for pentobarbital assay. Two dose schedules for TRH administration were used. One group of 6 animals received a single dose of 20 mg/kg 30 min after barbiturate administration, while the other group were received 3 injections of 20 mg/kg spaced at 30, 40 and 50 min after injection of pentobarbital. Both groups were sex balanced. TRH administration resulted in dramatically increased respiration and heart rates and arrested the progress of barbiturate induced hypothermia. The extended dose schedule prolonged increased respiration rate and a differential effect of TRH on pentobarbital induced hypothermia across sexes was observed. All animals regained reflexes sooner and sleeping time was reduced by 22%. No differences in pentobarbital blood levels with TRH were observed. These results extend earlier work in rodents to primates and suggest a possible use of TRH in cases of acute barbiturate intoxication.

Animals↗
PubMedDate not supplied

The feasibility of dobutamine stress echocardiography in the emergency department with telemedicine interpretation.

Dobutamine stress echocardiography (DSE) was performed on 26 patients admitted for chest pain deemed at low risk for myocardial infarction. Pharmacologic stress in the emergency department on a 24-hour basis was administered by nurses and echocardiographic ultrasonographers with electrocardiograms and echocardiograms being interpreted through telemedicine relay by an off-site cardiologist. Target heart rate was achieved in 84% of patients with an average peak dobutamine dose of 48 microg/kg/min. Echocardiographic transmission to the cardiologist over standard telephone lines took 9 minutes per quad-screen cine-loop display. The entire protocol added 2.2 hours to the emergency room evaluation. The one patient out of 26 who had incipient myocardial infarction was diagnosed by resting echocardiography. The remaining 25 patients were found clinically to have no infarction or ischemia. Of these, 22 out of 25 had normal DSE in the emergency department; three had wall motion abnormalities on peak stress images. Another three patients had other cardiac diseases documented by echocardiography. Evaluation of chest pain on a 24-hour basis with DSE with telemedicine interpretation appears to be a rapid and safe means of screening patients at low risk in the emergency department. Further experience with this modality is needed before all patients should be enrolled or early discharge of patients on the basis of DSE can be advised.

Adult↗
PubMedDate not supplied

Recent trends in morbidity and mortality rates for abdominal aortic aneurysms.

OBJECTIVES: To examine recent trends in mortality and morbidity rates from aortic aneurysms among Canadian seniors. DESIGN: Retrospective study. PARTICIPANTS: Men and women age 65 years or older who were hospitalized in Canada with a primary diagnosis of aortic aneurysm or whose underlying cause of death was aortic aneurysm. MAIN RESULTS: Unlike other circulatory diseases which have shown marked declines, mortality and morbidity rates from aortic aneurysms have remained constant over the last 10 years. Risks for male seniors are 4-5 times greater than for females. CONCLUSIONS: Since mortality and morbidity from aortic aneurysms have not decreased and screening offers potential benefits, costs and benefits of screening need to be quantified.

Aged↗
PubMedDate not supplied

Seasonality in epidemics of asthma mortality and hospital admission rates, Ontario, 1979-86.

Monthly trends in mortality and hospital admission rates attributed to asthma for those aged 15 to 34 for the province of Ontario were examined for the period 1979 to 1986. Graphs showing the monthly variation after the elimination of trend are presented. Time series models were constructed to evaluate the statistical significance. Asthma hospital separations peaked in the autumn and a test for seasonality was statistically significant (p less than 0.001). Although the pattern for asthma mortality was similar, the test for seasonality was not significant (p greater than 0.10).

Adolescent↗
PubMedDate not supplied

Diabetic impotence.

Explore the source record for details and available documents.

Diabetes Mellitus↗
PubMedDate not supplied

[The cellular aspects of the development of synovial joints and articular cartilage].

There have been many reports on the histological development of mammalian diarthrodial or synovial joints. While these are useful for comparative purposes, they tell us little of the cellular basis of joint morphogenesis which must underlie a number of morphogenetic defects. The process of joint morphogenesis is complex and can be subdivided into a number of facets and this report will focus on 2 of them. First, the process of joint cavitation in the chick metatarsophalangeal joint, where we propose that the selective secretion of hyaluronan into the presumptive cavity plays a central role. Secondly, the development of articular cartilage where we have used the South American opossum Monodelphis domestica as a model for mammalian development. Like most marsupials, the young are born at a much earlier developmental stage than eutherian mammals. Using antibodies which detect proliferating chondrocytes and those synthesizing insulin-like growth factors 1 and 2 and insulin-like growth factor 1 binding protein, we report that the majority of growth (as assessed by these indicators) appears appositional.

Animals↗