Biomedical subjects

H Muche

Publications and source records attributed to H Muche.

5 recordsLinked to original sources

PubMed1983

Refractory period impairment in sural nerves of diabetics.

Polyneuropathy is a frequent complication in diabetics. In a non-selected group of 65 diabetics, 30 patients had clinical signs of neuropathy. These patients had more significant changes in electrophysiological parameters than patients without clinically evident polyneuropathy. Significant reduction of sural nerve conduction velocity was observed in 16 of 30 patients with and in 4 of 35 diabetics without clinical signs of polyneuropathy. Additional information was obtained when paired stimuli were applied and the test response latency was measured. Stimulus intervals of 3 ms gave the highest quota of information about involvement of the sural nerve. Significant prolongation of the test response in paired stimulation at intervals of 3 ms was found in 21 of 30 patients with clinically apparent diabetic polyneuropathy and in 16 of 35 diabetics without clinical signs of polyneuropathy.

Adult↗

PubMed1980

[Principles of the automatic analysis of amplitude, transmission time, conduction velocity and refractory period of the compound nerve action potential of peripheral nerves. Results in the human sural nerve (author's transl)].

A method for the automatical determination of the amplitude, the transmission time, the conduction velocity and the refractory period of sural nerve was evaluated by help of HISTOMAT-S/MULTI 20 computer. The results of the automatical analysis were compared with those of the conventional method in 50 healthy control persons. There was no significant difference between the dates. Accuracy and correctness were exactly in the same range, but the investigation time of the analysis by help of a computer is much shorter.

Action Potentials↗

PubMed1980

Sural nerve conduction velocity and refractory period in diabetics without clinical signs of neuropathy.

Twentysix patients aged 22-76 years with a duration of diabetes of 1 month to 23 years but without signs of symptoms of a peripheral nerve disease were studied. The nerve conduction velocity, the amplitude of the compound action potential and its restitution during the relative refractory period were examined in sural nerves. Nerve conduction velocity of the motor fibers were determined in the median, ulnar, tibial, and peroneal nerves. A reduced conduction velocity in motor nerves of the lower extremities were found in 10%, a reduced sensory nerve conduction velocity in 25%, and pathological changes of the refractory period in 50% of the patients. It is concluded that the determination of the relative refractory period can be used as a sensitive test in the early diagnosis of diabetic neuropathy.

Adult↗

PubMed1979

[Reversible alterations of peripheral nerve function in thyroid dysfunction (author's transl)].

In 7 patients with hyperthyroidism and 9 patients with hypothyroidism both thve before treatment and after a period of normal thyroid function of at least one year duration. As far as conduction velocity and relative refractory period are concerned there was no difference between hyperthyroid patients and normal persons, whereas in cases of hypothyroidism before treatment the conduction velocity was shown to be significantly reduced; moreover a prolonged relative refractory period and a decline in amplitude of the nerve action potential were found. These alterations of peripheral nerve function, interpreted as evidence of neuropathy, proved to be reversible when the thyroid function returned to normal.

Action Potentials↗

PubMed1977

Refractory period of human sural nerve action potential related to age in healthy probands.

150 sural nerves from 150 probands 10-70 years of age were investigated by applying supramaximal paired electric stimuli and recording the action potentials with needle electrodes. The responses to the first and second stimulus were evaluated with respect to latency and amplitude. Correlation of the electrophysiological findings with the age of the probands gave the following results: (1) Slight but statistical insignificant reduction of conduction velocity with advancing age up to 70 years. (2) Statistical significant decrease of amplitudes and prolongation of potential duration with advancing age. (3) No significant relationship between refractory period (latency and amplitude of the test response) and advancing age up to 70 years. The results are discussed in terms of their clinical meaning.

Action Potentials↗