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Biomedical subjects

H Muijser

Publications and source records attributed to H Muijser.

23 records · Page 2Linked to original sources
PubMed1980

Sensitivity of several cell systems to acrylamide.

Chick spinal ganglia, chick muscle cells combined with mouse spinal cord explants, C1300 neuroblastoma cells, Chinese hamster ovary cells and newborn rat cerebral cells were exposed to various concentrations of acrylamide in culture. Four morphological and 1 electrophysiological parameters were applied in order to score toxic effects. It appeared that the neurite formation of rat cerebral neurons was the most sensitive criterion showing an effect at 10(-7) M acrylamide.

Acrylamides↗
PubMed1979

A micro-electrode amplifier with an infinite resistance current source for intracellular measurements of membrane potential and resistance changes under current clamp.

A microelectrode amplifier for intracellular electrophysiological research is described. It is equipped with an electronic infinite resistance constant current source for the injection of current into biological cells. With this amplifier the potential changes, the resistance changes and the dependence on extrinsic current of single cells can be measured independently and simultaneously.

Animals↗
PubMedDate not supplied

Mid-frequency hearing loss and reduction of acoustic startle responding in rats following trichloroethylene exposure.

Modification of auditory evoked startle responding using prepulse inhibition was used to examine the effects of trichloroethylene (TCE) exposure on auditory thresholds. Rats were exposed by inhalation to 0, 1500, or 3000 ppm TCE for 18 hours per day, 5 days a week for 3 weeks. Auditory thresholds for 5 and 20 kHz tones were measured before exposure and at 1, 3, and 6 weeks postexposure. In addition, hearing thresholds for 5 and 35 kHz tones were examined at a 5-week postexposure time-point. Results indicated that hearing thresholds for 20 kHz but not for 5 or 35 kHz prepulses were significantly increased in rats exposed to 3000 ppm TCE. These findings demonstrate a selective hearing loss in the 20 kHz range by short-term, high-level TCE exposure. With respect to effects on startle responding per se, the present study also found that compared to controls, TCE-exposed rats failed to show an increase in baseline startle with repeated testing. This difference could not be attributed to differences in body weight and was persistent throughout the postexposure period.

Acoustic Stimulation↗
PubMedDate not supplied

Behavioral effects of exposure to organic solvents in carpet layers.

Carpet layers and age-matched controls were investigated both at the beginning of a working day and at the end with four subtests of a neuropsychological test battery (NES2). Exposure to toluene, cyclohexane, ethyl acetate, and heptane was measured with personal air sampling methods. One group of carpet layers used water-based adhesives (WBA) on the day the investigation took place and the other group used contact adhesives (CA) on that day. The WBA group was exposed primarily to toluene, and the CA group was exposed to other solvents as well. Initial (before work) differences in neuropsychological scores between all exposed workers and controls could be attributed to differences in education, the carpet layers being somewhat higher educated. No differences were found between the solvent-exposed and control groups that would suggest persistent effects of chronic solvent exposures. The improvement in test scores over the day was the same in both groups. However, evidence for exposure-related changes in test scores over the day were found within the exposed group.

Adhesives↗