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Biomedical subjects

H Murota

Publications and source records attributed to H Murota.

9 recordsLinked to original sources
PubMed1996

Chemoembolization of head and neck cancer with carboplatine microcapsules.

Fourteen patients with malignant tumor in the head and neck region were treated with infusion of carboplatine microcapsules (CBDCA-mc) via percutaneous super-selective catheterization. A microcatheter was advanced into a feeding artery using a coaxial catheter system. Eleven patients had over 30% reduction of the tumor size on CT within 1 month after embolization. Twelve patients had an increased amount of low attenuation tissue in the tumor on CT after embolization, suggesting increased necrosis in the tumor. No definite hematologic toxicity was found. A majority of patients complained of moderate pain in the embolized region immediately after embolization, easily relieved by i.v. analgesics. Chemoembolization using CBDCA-mc may be an effective therapeutic modality in advanced cases of head and neck cancer.

Aged↗
PubMed1984

Magnetic microcapsules for targeted delivery of anticancer drugs.

To achieve targeted distribution of anticancer drugs with sustained activity, ferromagnetic ethylcellulose microcapsules containing an anticancer drug, mitomycin C (FM-MMC-mc), were prepared by a method based on phase separation principles. Two prototypes of FM-MMC-mc were made: one with the drug as the core and zinc ferrite on its capsular surface (outer type); the other with both the drug and zinc ferrite as the core (inner type). Both preparations provided a sustained-release property and a sensitive response to conventional magnetic force, although certain differences in the release rate of drug, magnetic responsiveness, and particle size were found between the two dosage forms. Animal studies showed that the magnetic microcapsules could be magnetically controlled in the artery and urinary bladder. VX2 tumors in the rabbit hind limb and urinary bladder were successfully treated with magnetic control of FM-MMC-mc. Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time. The results indicate the feasibility and effectiveness of the magnetic microcapsules as a targeted drug delivery system.

Animals↗
PubMed1983

Antimicrobial activity of topical beta-adrenergic blocking agents.

Three topical beta-adrenergic blocking agents without preservatives were tested for their ability to inhibit the growth of five microorganisms in vitro. Timolol maleate and befunolol hydrochloride showed no antimicrobial activity; however, bupranolol hydrochloride inhibited microbial growth. The minimum inhibitory concentration of bupranolol hydrochloride was 0.1% for Bacillus subtilis and 0.05% for Staphylococcus aureus and Escherichia coli.

Adrenergic beta-Antagonists↗