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Biomedical subjects

H N Seth

Publications and source records attributed to H N Seth.

At least 19 recordsLinked to original sources
PubMed1990

A simple method of evaluation of jaundice in the newborn.

This paper evaluates a simple tool, the icterometer, in assessing jaundice in the newborn. The instrument consists of a perspex scale with yellow stripes of increasing intensity, numbered 1-5, alternating with transparent areas through which the infant's blanched skin colour can be seen and compared with the coloured stripes. The scale was found to be useful for more objective screening of neonatal jaundice, particularly in decreasing the number of blood samples to be taken for serum bilirubin. The present study suggests that serum bilirubin estimation can be avoided when the icterometer readings on the face are 3 or less, unless there is a rapid rise in jaundice within 24-36 h. However, a reading on the sole of even 1 is significant and requires assessment by trained staff for blood sampling and/or phototherapy. The instrument may also be useful to peripheral staff in developing countries when deciding on referral to specialist centres and to staff in specialist centres for screening cases of neonatal jaundice and decreasing the number of blood samples.

Bilirubin↗
PubMed1978

Platelet adhesiveness, plasma fibrinogen, and fibrinolytic activity in young patients with ischaemic stroke.

Cerebral thromboembolic stroke in the young is uncommon. Disturbances in the n ormally existing dynamic equilibrium between coagulation and fibrinolysis may play a major role in the pathogenesis of such episodes. In a search for a possible hypercoagulable state platelet adhesiveness by the method of Eastham, plasma fibrinogen and euglobulin clot lysis times were estimated in 46 patients. A group of 15 normal subjects matched for age and sex were also studied for comparison. Significant increase in platelet adhesiveness (P less than 0.001) and plasma fibrinogen (P less than 0.001) was noted in the patients when compared with the normal subjects. Absence of corresponding increases in fibrinolytic activity in the patients suggests disturbed equilibrium between coagulation and fibrinolysis. The possibility of a hypercoagulable state in these cases is discussed.

Adult↗
PubMed1977

Platelet adhesiveness in young patients with ischaemic stroke.

A significant increase in platelet adhesiveness was observed in 13 patients who developed ischaemic stroke at high altitude and in 43 patients who developed stroke at low altitude when compared with a similar group of normal healthy volunteers. Eighty-eight percent of the patients were below the age of 40 years. The role of platelet adhesiveness in the pathogenesis of cerebral schaemia in young patients is discussed.

Adolescent↗
PubMed1977

Neurological and related manifestations of cysticercosis.

Neurological and related manifestations of 17 cases of human cysticercosis have been reported. The cases have been grouped into convulsive disorder (6 cases), meningo-encephalitis (4 cases), pseudo-tumour syndrome (2 cases), psychiatric disease (2 cases), ocular cysticercosis (2 cases) and pseudomuscular hypertrophy (1 case) which proves the varied clinical manifestations of the disease.

Adolescent↗
PubMed1976

Rhinoentomophthoromycosis.

A rare case of Rhinophycomycosis entomophthora treated with a combination of Bacterium, potassium iodide and steroid is reported. Clinical features, epidemiology, mycology, and management are discussed.

Adult↗
PubMed1975

Effect of submaximal exercise on fibrinolytic activity in ischaemic heart disease.

Fibrinolytic activity and platelet adhesiveness are normal in cases of angina pectoris and healed myocardial infarction, whereas fibrinolytic activity is diminished in acute myocardial infarction. Exercise increases fibrinolytic activity in normal people but the effect on it of submaximal exercise in patients with ischaemic heart disease is not known. Resting platelet adhesiveness and fibrinolytic activity were determined in 20 patients suffering from ischaemic heart disease and eight healthy controls. Both groups were then subjected to submaximal exercise on a motor-driven treadmill. The ST segment of the electrocardiogram and the heart rate were monitored during exercise by an on-line digital computer. Fibrinolytic activity determinations were repeated immediately after exercise. There was a significant increase in fibrinolytic response in both groups but it was significantly less in the ischaemic groups (36-2%) compared with the controls (55-9%) (P less than 0-01). The ST segment depression was 2-3 mm in the ischaemic group and 0-52 mm in controls--also a significant difference (P less than 0-01). There was no correlation, however, between the ST change and the fibrinolytic response. A diminished response in the ischaemic group may favour their predisposition to thrombotic episodes.

Adult↗