Biomedical subjects
H N Uhley
Publications and source records attributed to H N Uhley.
Usefulness of direct linkage of physicians' office terminals to a hospital laboratory computer.
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Lymphatic drainage from the ventricular septum to the atrioventricular node in human beings.
It has been suggested that intracardiac lymphatics may play a role in the pathophysiologic processes involving the conduction system. To test the possibility of linkage between the ventricular septum and the atrioventricular (AV) node, india ink was injected into the ventricular septum of freshly removed human hearts. Microscopic sections of the AV node and adjacent tissue were examined for the presence of india ink. India ink was seen in and near the AV node in lymphatic channels and small veins. The implication is that potentially noxious materials can be transmitted by lymphatics from remote areas and influence adjacent conduction system fibers. Thus, it is possible that AV conduction disturbances after myocardial infarction may be induced by a lymphatic mechanism.
Thoracic duct and right lymphatic duct: surgical approaches for drainage in the canine with comparison of cellular and chemical contents.
The technics of drainage of the right lymphatic duct (RD) and thoracic duct (TD) used in our laboratory have been described and illustrated. In two series of experiments the components of RD and of TD lymph were compared to blood plasma collected concurrently. RD and TD lymph, collected concurrently, were also compared in a third series. RD and TD lymph differ in a number of ways including rate of flow, enzyme activity, cell count and lipid-electrophoretic patterns. The limitations of RD lymph for the study of fluid and protein dynamics of the lungs and the cell population of lung lymph are outlined. Higher levels of enzyme activity in RD compared to TD lymph have been noted. This phenomena appears to depend on a number of complex factors.
A method for the collection of pure pulmonary lymph in the canine.
An original method for the collection of pure or nearly pure pulmonary lymph in the canine is desirable for the study of pulmonary water, protein dynamics and cells. Right lymphatic duct lymph has been used extensively but it known to contain lymph from a number of extrapulmonary sources and has been altered by passage through lymph nodes. Pulmonary lymph was collected from 13 dogs through an open chest. The mean flow of lymph was 1.5 milliliters per hour +/- 0.08. This flow is compared with 3.7 milliliters per hour from the right lymphatic duct and 22.5 milliliters per hour from the thoracic duct in a group of dogs with a closed chest. The levels of lactate dehydrogenase--634 units per liter--and glutamic-oxalacetic transaminase--416 units per liter--in pure pulmonary lymph were much higher than in right lymphatic duct lymph--lactate dehydrogenase 125 units per liter; glutamic-oxalacetic transaminase 94.0 units per liter, in thoracic duct lymph--lactate dehydrogenase 47 units per liter; glutamic-oxalacetic transaminase 80.5 units per liter--and in blood plasma--lactate dehydrogenase 299 units per liter; glutamic-oxalacetic transaminase 95 units per liter. Low levels were noted in Na+, 107, and Cl-, 85, in pure pulmonary lymph versus plasma--Na+ 145; Cl- 112, right lymphatic duct lymph--Na+ 146; Cl- 115, and thoracic duct lymph--Na+ 146; Cl- 114. The method can be adapted for prolonged drainage in conscious dogs, which would enhance its usefulness.
T-lymphocytes in venous blood and lymph from the thoracic duct and right lymphatic duct of normal dogs.
The WBC and per cent polymorphonuclear cells in blood increased significantly during the approximately 3 hours of the experiments. The number of lymphocytes did not change significantly. Corresponding cellular components in RD and TD lymph were not significantly different. The per cent of T-rosettes in FVB was more than three times that in RD and TD lymph (33/10). T-rosettes were predominantly formed by medium lymphocytes (68-82%) in both blood and lymph.
T-lymphocytes in experimental myocardial infarction.
The WBC count, percentage of PMN's, lymphocyte counts and percentage of T-cells in blood, right duct and thoracic duct lymph of three- and nine-day post-coronary ligation and corresponding sham dogs were studied. It was observed that the percentage of T-cells in the right duct lymph of the nine-day post-coronary ligation group was significantly increased compared to the sham group, suggesting a possible cellular immune response late in the infarction process.
The concept of trifascicular intraventricular conduction: historical aspects and influence on contemporary cardiology.
The efforts of Mauricio Rosenbaum and his co-workers in putting together the anatomic and electrocardiographic correlations that led to the development of the concept of trifascicular intraventricular conduction have had a major impact on electrocardiography. Perhaps the greatest testimony to their contributions is the large number of related publications by many authors since the printing of Los Hemibloqueos more than 10 years ago.
Lymphatic pathways and rate of absorption of 131I-albumin from pericardium of dogs.
Labeled albumin diluted to 4.0 ml with normal saline solution was instilled into the pericardium of 14 dogs. Lymph from the right lymphatic duct (RD) and thoracic duct (TD) was collected at intervals as well as blood samples, and radioactivity measured.
An inexpensive receiver for ECG telemetry.
A simple, inexpensive ECG demodulator circuit has been described which may be used in conjunction with an ECG telephone transmitter, telephone amplifier, and ECG recorder to form a telemetry system capable of ECG monitoring.
A low cost ECG cassette tape library.
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Canine cardiac lymph potassium, pH and flow after experimental myocardial infarction.
Canine cardiac lymph was studied after acute experimental myocardial infarction. The lymph potassium concentration remained the same, the lymph potassium content increased, the lymph pH decreased, and the lymph flow increased while the serum potassium and pH remained the same. It is suggested that localized hypoxia may result in cellular changes that release substances, e.g., potassium, to the interstitial space where they mobilize fluid and enhance lymph flow.
Lymphatics of the canine papillary muscles.
A relatively dense concentration of lymphatics in the region of the papillary muscles of the canine left ventricle has been described. It is suggested that these channels may play a role in the development of pathologic changes affecting the mitral valve apparatus which could subsequently cause valve dysfunction.
An inexpensive portable ECG transmitter.
A small, easy-to-construct, pocket-sized ECG telephone transmitter utilizing few components and costing less than $20.00 is described. The tone produced varies with the ECG signal and may be transmitted over the telephone system to a demodulator and ECG recorder for permanent records and interpretation, as well as serving as an indicator of the ECG signal at the bedside. This simple device provides useful information on patients with various clinical problems.
A simple method of checking the ECG paper speed.
A simple method of determining accurate rates on ECG machines has been described. A short-wave radio, capable of tuning station WWV (5, 10 or 15 MHz) and a telephone amplifier may be used to place the precise 1 second intervals pulses on the ECG, from which exact paper speed is determined. This information may then be used to calculate the precise rate of an implanted pacemaker stimulus for evaluating pacemaker battery life.
Cardiopulmonary resuscitation: basic life support.
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Automatic monitoring for all patients.
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Atrioventricular and intraventricular conduction. Revised nomenclature and concepts.
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