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Biomedical subjects

H N Wang

Publications and source records attributed to H N Wang.

8 recordsLinked to original sources
PubMed1998

Pharmacokinetics of 5-fluorouracil and its penetration into pancreatic juice in dogs.

AIM: To study the pharmacokinetic behavior of 5-fluorouracil (5-FU) in pancreatic juice in dogs and its correlation with 5-FU in plasma, and to evaluate its penetration characteristics. METHODS: After placing a pancreatico-drainage tube, 8 dogs were injected 5-FU 250 mg i.v. Blood and pancreatic samples were collected and the 5-FU concentrations were determined by HPLC. The pharmacokinetic parameters were obtained with statistical analysis. RESULTS: The mean slopes of the terminal phase (K10) in plasma and pancreatic juice were 9.4 h-1 and 10.2 h-1, respectively (P > 0.05). The pharmacokinetic behaviors of 5-FU in plasma and pancreatic juice fitted a nonlinear model. Its penetration index was 3.39 +/- 2.84. The penetration of 5-FU from blood to pancreatic juice was relatively rapid, demonstrating a consistently higher concentration in pancreatic juice than in plasma. CONCLUSIONS: The elimination phase of 5-FU in plasma was similar to that in pancreatic juice, indicating that they were in the same kinetic compartment.

Animals↗
PubMed1990

Detection of early pregnancy factor in fetal sera.

Utilizing rosette inhibition test recommended by Morton et al., (Morton H, Tinneberg HR, Rolfe M, Mettier L. Rosette inhibition test: a multicenter investigation of early pregnancy factor in humans, J Reprod Immunol. 1982; 4:251-261) we have examined 44 fetal sera of abortion induced by water bag in the second and third trimester pregnancy, 4 umbilical sera of newborns, and their 48 maternal sera for detecting early pregnancy factor (EPF), which activity was expressed as rosette inhibition titre (RIT). The mean RIT value of EPF in fetal sera was 6.00 +/- 0.31 (SD) during 16-17 weeks of gestation, gradually decreased along with gestational weeks, got to 4.25 +/- 0.25 by term. The mean RITs of EPF activity in maternal sera were 5.86 +/- 0.26 and 5.89 +/- 0.35 during 5-7 weeks and 18-19 weeks, respectively, decreased afterwards, and then fell into nonpregnant range (RIT: 4.00 +/- 0.40) after 31 weeks of gestation. There was a close correlation between RITs of 44 fetal and those of their maternal sera (r = 0.615; P less than 0.001). The results revealed the presence of EPF in fetal serum during gestation. The significance of EPF distribution and its possible role of immunological regulation on survival of semiallogeneic conceptus have thus been discussed.

Amniotic Fluid↗
PubMed1989

[The gap phenomena during ventriculoatrial conduction in man].

Eleven patients with retrograde gaps by conventional electro-physiological studies were reported. Most of the patients were studied because of arrhythmia. Electrical activity of the His bundle, atrium and routine ECG were recorded simultaneously. The excitability and characteristics in retrograde conduction were observed, using the programmed ventricular stimulus. The results of this study showed that two types of retrograde gaps occurred, Type I: The site of proximal delay was within the His Purkinje system (HPS), and the site of distal block was in the A-V node. Three of the 11 cases were of this type. Type II: Both the site of proximal delay and distal block are within the HPS in eight of the 11 cases. Comparing the data with those from our lab about the gap phenomena during atrioventricular conduction in 10 cases, it was found that in the gap phenomena of A-V conduction, the site of proximal delay is usually within the A-V node, whereas the site of distal block was in the HPS. In the gap phenomena of V-A conduction the site of distal block might be either above or below the His bundle, but the site of proximal delay was only occurred in the HPS. So retrograde gaps were more common than antegrade gaps depending upon the ratio of the functional refractory periods of two horizontal region in the A-V (or V-A) conduction system.

Adolescent↗
PubMed1989

[Studies on synthesis of baogongteng A--a new myotic agent].

Baogongteng A, isolated from Erycibe obtusifolia Benth., is a new tropane alkaloid used for treating glaucoma. Using synthetic 6 beta-acetoxy-tropinone as starting material, racemic Baogongteng A(8) was synthesized. Synthetic Baogongteng A also shows myotic activities in rabbits, but the potency is half of that of the natural product.

Bridged Bicyclo Compounds↗
PubMedDate not supplied

Isolation and identification of infectious bronchitis virus from chickens in Sichuan, China.

A nonhemagglutinating virus was isolated from kidneys and lungs of chickens suspected of having infectious bronchitis infection. Specific-pathogen-free embryonated chicken eggs were used as the cultural system. With the use of the ciliary activity of chicken embryo tracheal organ cultures as indicator system, the physicochemical properties of one of the isolated strains (SAIB3) were shown to be similar to infectious bronchitis virus (IBV) strain M41 (standard strain); whereas electron microscopy of the isolate showed coronavirus particles. Virus-neutralization tests were performed in tracheal organ cultures to compare the serotypes of five IBV isolates and six known IBV strains on the basis of reciprocal neutralization titers and euclidean distance. The cross-neutralization pattern indicated that one isolate was of the T-strain IBV serotype, another of the M41 IBV serotype, while others had partial serotype relationship to M41 and T-strains of IBV.

Animals↗