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Biomedical subjects

H Nadimi

Publications and source records attributed to H Nadimi.

16 recordsLinked to original sources
PubMed1994

Subclasses of extranodal oral B-cell lymphomas express cIgM, plasmacytoid, and monocytoid differentiation. A study of 10 cases.

Light microscopic and immunohistochemical findings in 10 extranodal oral B-cell lymphoproliferations are described. Three lymphomas were of the small lymphocytic/plasmacytoid type that also contained immunoblasts. Five lymphomas were monocytoid type with folded nuclei and pale-staining cytoplasm. Two lymphomas were of the large-cell type and contained multilobated blast cells, a low-grade neoplastic lymphoid component, and tumor plasma cells. All lymphomas were reactive with B-cell specific 4KB5, LN-2, L26, and LN-1 antibodies. There was a variable expression of intracytoplasmic mu heavy chain and monotypic kappa or lambda light chains with neoplastic lymphoplasmacytoid cells and plasma cells. These subclasses of primary oral lymphomas express the histologic and immunophenotypic likeness as well as the immunoreactive spectrum of parafollicular B cells. They may have an intimate morphogenetic association with that of the mucosa-associated lymphoid tissue lymphoma.

Adult↗
PubMed1993

Uremic mixed bone disease. A case report.

Renal osteodystrophy (ROD) is a complex disease of bone caused by renal failure. A case of uremic mixed bone disease with severe maxillofacial involvement is reported. The pathogenesis and various pathologic features of ROD are discussed.

Adult↗
PubMed1990

Coexpression of cytokeratins, involucrin, and blood group antigens in oral squamous cell carcinomas.

The well and poorly differentiated oral squamous carcinomas preferentially express proteins, blood group antigens, and contain associated dendritic Langerhans' cells. Keratin pearls in well-differentiated carcinomas simulate the differentiation pathway of the normal oral squamous epithelium, whereas poorly differentiated carcinomas do not and appear more heterogeneous. Terminally keratinized cells correlate with involucrin and expression of blood group antigens in keratin pearls, a feature that differs from the nonkeratinizing normal epithelium in which such carcinomas arise. Dendritic Langerhans' cells are reduced in number in squamous carcinomas.

ABO Blood-Group System↗
PubMed1989

Rhabdomyosarcoma of the parapharyngeal space in an adult patient: an immunohistochemical study.

Rhabdomyogenic malignancies occasionally challenge the diagnostic acumen of many pathologists. The diverse histologic patterns of RMS can range from the somewhat undifferentiated primitive to the bizarre, pleomorphic varieties. These neoplasms can be highly lethal and, until recently, were resistant to even the most aggressive surgical management. The grave prognosis for patients with RMS has remarkably improved however, as a result of careful clinical staging, awareness of histologic features and immunohistochemical techniques for identification, newer techniques in defining the extent of the disease, and multimodal therapy consisting of surgery, radiation, and chemotherapy. Immunohistochemical methods with specific antibodies, as used in this case, have proved to be the only definitive method to identify this variant subclass of RMS.

Adult↗
PubMed1989

Immunohistochemical localization of Leu-M1 carbohydrate antigen in human oral squamous cell carcinoma.

Twenty-six biopsy specimens of oral squamous cell carcinomas were examined by the avidin biotin peroxidase complex (ABC) method for the presence of an epithelial cell membrane bound lacto-N-fucopentaose III, known also as Leu-M1 or Lex antigen. In normal oral epithelium, Leu-M1 antigen was expressed on keratinizing epithelia in the stratum spinosum. In well-differentiated carcinomas the antigen was found on the cell membrane of nucleate cells in infiltrating epithelial islands. Such pattern in moderately well and in poorly differentiated carcinomas was minimally expressed and was associated with flattened squamous cells or otherwise recorded negative. Leu-M1 antigen immunoreactivity in normal oral epithelia and in carcinomas was comparable to that of blood group H-2 chain that were examined. It was concluded that the intensity of the reaction parallels the magnitude of differentiation of epithelia. Leu-M1 antigen can serve as a marker of differentiation in oral squamous epithelium.

Animals↗
PubMed1988

T-cell lymphoma of palatal midline. Report of 2 cases.

2 cases of unifocal T-cell lymphomas, predominantly large cell type, one restricted to the midline of the palate and the other involving the nasal cavity are reported. Monoclonal antibodies served as a useful adjunct to light microscopy in diagnosing these tumors.

Diagnosis, Differential↗
PubMed1988

Expression of endothelial cell markers PAL-E and EN-4 and Ia-antigens in Kaposi's sarcoma.

Eleven biopsy specimens of Kaposi's sarcoma (KS) removed from the skin and oral mucosa were examined immunohistochemically with monoclonal antibodies PAL-E and EN-4, specific for human vascular endothelial cells, and with LN-3 monoclonal antibody reactive with immune-associated (Ia) antigens in the HLA-DR locus. The early lesions of KS, corresponding to the patch phase, contained hyperplastic venules and an increased number of lymphatic capillaries. The lymphatic capillary endothelium was reactive with EN-4, whereas, PAL-E reacted only with blood vessel endothelial cells. The spindle cells, like lymphatic endothelial cells, were non-reactive with PAL-E but showed positive reaction with EN-4 antibodies. The observed morphologic pattern of vasculogenesis and the demonstrated immune-reactivity in KS support an origin from the venule-lymphatic junction. This is an aberrant pattern but reminiscent of normal embryonal lymphatic channel development. The lymphatic capillaries and vascular slits were nonreactive with LN-3 antibody, but it was positive on cell membranes in a number of spindle cells, suggesting the focal expression of Ia-antigens.

Antibodies, Monoclonal↗
PubMed1987

Aneurysmal bone cyst associated with a dentigerous cyst: report of case.

An aneurysmal bone cyst associated with a dentigerous cyst filled the entire maxillary right sinus and corresponding eroding portions. The report discusses the unusual presence of a dentigerous cyst, documentation of an aneurysmal bone cyst associated with a primary lesion, and offers suggestions as to the common pathogenesis of the two lesions.

Adult↗
PubMed1986

Product identification of ameloblastomas: an immunohistochemical study.

Twenty-nine solid, plexiform and follicular ameloblastomas and control human developing teeth at different stages of maturation were formalin-fixed, paraffin-embedded and sectioned for the study of laminin, fibronectin, and mannosyl, glucosyl, and galactosyl residues using the peroxidase antiperoxidase (PAP) and avidin-biotin peroxidase complex (ABC) staining methods, respectively. Monospecific antibodies to laminin and fibronectin and the affinity of the lectins for mannosyl, glucosyl, and galactosyl residues with RCA-I. Laminin is present during the stage of morphodifferentiation of normal tooth development within the basement membrane. Following cytodifferentiation and calcified matrix deposition, laminin is not detectable. Laminin is also found in the basement membrane of both follicular and plexiform ameloblastomas. In contrast, fibronectin is reactive only up to the stage of morphodifferentiation among the mesenchymal cells and at the epithelial-mesenchymal interface, and it becomes unreactive upon differentiation of odontoblasts and mesenchymal pulp tissue as well. Unlike laminin, fibronectin is unreactive in the basement membrane of plexiform follicular and ameloblastomas.

Adult↗
PubMed1985

Pemphigus vulgaris and malignancy.

A case of oral squamous cell carcinoma with pemphigus vulgaris is reported and the literature is reviewed. Association between the above entities has essentially been founded upon the specificity of cancer-associated antigen. To date, such an antigen has not been adequately defined, and, therefore, any causal relationship between the 2 processes on the grounds of antigenic-specificity of cancer cells remains unjustified. Hence, pemphigus and malignancy may occur as a coexisting phenomenon.

Antigens, Neoplasm↗