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Biomedical subjects

H Nadjem

Publications and source records attributed to H Nadjem.

6 recordsLinked to original sources

[Unexpected fatalities in childhood caused by acute epiglottitis].

Report on two deaths from a natural internal cause in children beyond the first year of life. The children (a two-year and a three-year old boy), who seemed completely healthy, sudden suffered from acute inflammation of the upper respiratory tract with dyspnea, inspiratory stridor, fever, dysphagia, and flow of saliva. The disease took a fulminant course and the children died within a few hours showing symptoms of intense dyspnea and cyanosis. The above symptoms and progress were typical of acute epiglottitis. Autopsy revealed an intense inflammation and tumescence of the epiglottis in both cases. The diagnosis of epiglottitis was confirmed histologically and bacteriologically (Haemophilus influenzae).

Acute Disease

[Agonal dog bite injuries].

A 57-year-old woman, who was unconscious due to apoplectic cerebral haemorrhage, was injured on the right thigh by dog bites while still alive. In addition to a soft-tissue defect of 10 x 9 x 3 cm (gnawing effect) there were numerous small single lesions in the form of slit-shaped skin cuts. The area around the wounds was discoloured by haematomata. The bite wounds were caused by the mongrel dogs living in the same household (2 parent animals and 6 puppies). The pattern of the injuries corresponded well to the anatomy of a dog's set of teeth.

Animals

[Hematoma in acute leukemia--suspected diagnosis of child abuse].

A 4-year-old child, suspected of being the victim of child abuse was sent for forensic examination. The examination established multiple, uncharacteristically shaped haematomata in various parts of the body. In addition, petechiae were also present. In view of the nature and localisation of the haematomata and the presence of petechial bleeding a differential diagnosis considered the possibility of a haematological disease and clinical paediatric tests were done to establish the cause, which showed an acute lymphatic leukaemia (ALL) with thrombo(cyto)penia. As haematomata are often the first indication of a leucosis, whenever child abuse is suspected, this possibility should also be considered.

Child Abuse

[Fatal intoxication following rectal instillation of alcohol].

A 62-year old man who had been living on a remote farm was found dead in his bed. Inserted in his rectum was a synthetic flexible tube filled with brandy (43 vol. %) and connected to a bicycle pump. Samples taken during autopsy from 3 different parts of the body showed ethanol concentrations from 4.87% to 5.35% in the blood and 6.73% in the urine. The ethanol concentrations in the small and large intestine were considerably higher (more than 29%) than in the stomach (9%). The decreased had a tumor as large as a tennis ball on the base of his tongue, almost completely filling the oropharynx, making swallowing very difficult, which probably was the reason of the rectal instillation of alcohol. The report deals with this unusual case of rectal alcohol instillation, and with the different ethanol and congener alcohol concentrations in the body fluids.

Administration, Rectal

[Histopathologic changes in several opportunistic infections in AIDS].

Opportunistic infections are frequent in AIDS patients, particularly in the last phase of the disease, when they occur both singly and in combination with other conditions (for example KAPOSI's sarcoma). These opportunistic infections are the cause of death in over 90% of cases. Their incidence ist proof of cellular immunodeficiency. Based on our observations (17 cases at the two institutes since 1984) we present and discuss the histopathological changes of some important opportunistic infections (notably Pneumocystis carinii pneumonia, Mycobacteriosis (MAI), Cryptosporidium Cytomegalovirus and Toxoplasmosis gondii infection).

Acquired Immunodeficiency Syndrome

Surveillance, prevention and control of hospital-acquired infections. III. Nosocomial infections as cause of death: retrospective analysis of 1000 autopsy reports.

One thousand post-mortem reports were analysed retrospectively to see whether the patient had had a nosocomial or community-acquired infection and whether this led directly to or contributed to the patient's death. In 7.4% of all autopsies nosocomial infection was the direct cause of death. In 6.3% of the patients, nosocomial infection was a contributory factor leading to death. The most common hospital infections were pneumonia, septicaemia, peritonitis, meningitis, and hepatitis B. Most infections which led to or contributed to death were acquired in surgical wards. Patients with nosocomial infections, however, were more endangered by factors predisposing to infections (1.8 factors per patient) than patients without nosocomial infections (0.67 factors per patient). Sixty-three patients acquired an infection outside the hospital; in 70% of these patients, the infection was the main or contributory cause of death.

Adolescent